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The protein encoded by SPG21 was identified by a two-hybrid screen using CD4 as the bait. Additionally we are shipping SPG21 Antibodies (31) and many more products for this protein.
Showing 10 out of 21 products:
Human SPG21 Protein expressed in Baculovirus infected Insect Cells - ABIN2002997
Hanna, Blackstone: Interaction of the SPG21 protein ACP33/maspardin with the aldehyde dehydrogenase ALDH16A1. in Neurogenetics 2009
Show all 5 references for ABIN2002997
Mouse (Murine) SPG21 Protein expressed in Baculovirus infected Insect Cells - ABIN2008303
Zeitlmann, Sirim, Kremmer, Kolanus: Cloning of ACP33 as a novel intracellular ligand of CD4. in The Journal of biological chemistry 2001
Show all 4 references for ABIN2008303
Human SPG21 Protein expressed in Escherichia coli (E. coli) - ABIN666752
Simpson, Cross, Proukakis, Pryde, Hershberger, Chatonnet, Patton, Crosby: Maspardin is mutated in mast syndrome, a complicated form of hereditary spastic paraplegia associated with dementia. in American journal of human genetics 2003
Show all 2 references for ABIN666752
HBV X gene enhanced SPG21 gene promoter activity, SPG21 mRNA expression and SPG21 protein production in HepG2 cells in a dose-dependent manner.
frameshift results in the premature termination of the encoded product, which is designated "maspardin" (Mast syndrome, spastic paraplegia, autosomal recessive with dementia)
Data report that maspardin localizes prominently to cytoplasm as well as to membranes, possibly at trans-Golgi network/late endosomal compartments, and that maspardin interacts with the aldehyde dehydrogenase ALDH16A1 (show ALDH16A1 Proteins).
Study showed that the loss of maspardin attenuates the growth, maturation, and axonal branching of cortical neurons to promote progressive neuronal dysfunction; impairment of sensory motor neurons in SPG21-/- mice; and that SPG21-/- cortical neurons failed to respond to EGF (show EGF Proteins)-induced growth and maturation, which is confirmed by the attenuated expression of a subset of EGFR (show EGFR Proteins) target genes
Mast syndrome gene SPG21 in mice has a role in hind limb function and axon branching in cultured cortical neurons
The protein encoded by this gene was identified by a two-hybrid screen using CD4 as the bait. It binds to the hydrophobic C-terminal amino acids of CD4 which are involved in repression of T cell activation. The interaction with CD4 is mediated by the noncatalytic alpha/beta hydrolase fold domain of this protein. It is thus proposed that this gene product modulates the stimulatory activity of CD4. At least three different transcript variants encoding two different isoforms have been found for this gene.
spastic paraplegia 21
, acid cluster protein 33
, spastic paraplegia 21 autosomal recessive Mast syndrome protein homolog
, spastic paraplegia 21 homolog
, spastic paraplegia 21, maspardin (autosomal recessive, Mast syndrome)