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Spastic Paraplegia 21 Proteins (SPG21)

The protein encoded by SPG21 was identified by a two-hybrid screen using CD4 as the bait. Additionally we are shipping SPG21 Antibodies (30) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SPG21 51324 Q9NZD8
SPG21 27965 Q9CQC8
SPG21 300791 Q5XIC4
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Top SPG21 Proteins at antibodies-online.com

Showing 10 out of 21 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Baculovirus infected Insect Cells Human GST tag 100 μg Log in to see 16 Days
$437.80
Details
HOST_Baculovirus infected Insect Cells Mouse His tag,GST tag 100 μg Log in to see 16 Days
$437.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,674.83
Details
Yeast Macaca fascicularis His tag   1 mg Log in to see 56 to 66 Days
$2,821.50
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,821.50
Details
Yeast Pongo abelii His tag   1 mg Log in to see 56 to 66 Days
$2,821.50
Details

SPG21 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
,
Mouse (Murine) ,
,
Rat (Rattus)

Top referenced SPG21 Proteins

  1. Human SPG21 Protein expressed in Baculovirus infected Insect Cells - ABIN2002997 : Hanna, Blackstone: Interaction of the SPG21 protein ACP33/maspardin with the aldehyde dehydrogenase ALDH16A1. in Neurogenetics 2009 (PubMed)
    Show all 5 references for ABIN2002997

  2. Mouse (Murine) SPG21 Protein expressed in Baculovirus infected Insect Cells - ABIN2008303 : Zeitlmann, Sirim, Kremmer, Kolanus: Cloning of ACP33 as a novel intracellular ligand of CD4. in The Journal of biological chemistry 2001 (PubMed)
    Show all 4 references for ABIN2008303

  3. Human SPG21 Protein expressed in Escherichia coli (E. coli) - ABIN666752 : Simpson, Cross, Proukakis, Pryde, Hershberger, Chatonnet, Patton, Crosby: Maspardin is mutated in mast syndrome, a complicated form of hereditary spastic paraplegia associated with dementia. in American journal of human genetics 2003 (PubMed)
    Show all 2 references for ABIN666752

More Proteins for Spastic Paraplegia 21 (SPG21) Interaction Partners

Human Spastic Paraplegia 21 (SPG21) interaction partners

  1. HBV X gene enhanced SPG21 gene promoter activity, SPG21 mRNA expression and SPG21 protein production in HepG2 cells in a dose-dependent manner.

  2. frameshift results in the premature termination of the encoded product, which is designated "maspardin" (Mast syndrome, spastic paraplegia, autosomal recessive with dementia)

  3. Data report that maspardin localizes prominently to cytoplasm as well as to membranes, possibly at trans-Golgi network/late endosomal compartments, and that maspardin interacts with the aldehyde dehydrogenase ALDH16A1 (show ALDH16A1 Proteins).

Mouse (Murine) Spastic Paraplegia 21 (SPG21) interaction partners

  1. Mast syndrome gene SPG21 in mice has a role in hind limb function and axon branching in cultured cortical neurons

SPG21 Protein Profile

Protein Summary

The protein encoded by this gene was identified by a two-hybrid screen using CD4 as the bait. It binds to the hydrophobic C-terminal amino acids of CD4 which are involved in repression of T cell activation. The interaction with CD4 is mediated by the noncatalytic alpha/beta hydrolase fold domain of this protein. It is thus proposed that this gene product modulates the stimulatory activity of CD4. At least three different transcript variants encoding two different isoforms have been found for this gene.

Gene names and symbols associated with Spastic Paraplegia 21 Proteins (SPG21)

  • spastic paraplegia 21 (LOC100345833)
  • spastic paraplegia 21 (LOC100358285)
  • spastic paraplegia 21 (autosomal recessive, Mast syndrome) (SPG21)
  • spastic paraplegia 21 (autosomal recessive, Mast syndrome) (spg21)
  • spastic paraplegia 21 (H. sapiens) (spg21)
  • spastic paraplegia 21 homolog (human) (Spg21)
  • ACP33 protein
  • BM-019 protein
  • C78576 protein
  • D9Wsu18e protein
  • GL010 protein
  • Maspardin protein
  • MAST protein
  • wu:fd07h02 protein
  • zgc:73091 protein

Protein level used designations for Spastic Paraplegia 21 Proteins (SPG21)

spastic paraplegia 21 , acid cluster protein 33 , maspardin , spastic paraplegia 21 autosomal recessive Mast syndrome protein homolog , spastic paraplegia 21 homolog , spastic paraplegia 21, maspardin (autosomal recessive, Mast syndrome)

GENE ID SPECIES
100345833 Oryctolagus cuniculus
100358285 Oryctolagus cuniculus
51324 Homo sapiens
404069 Bos taurus
415526 Gallus gallus
487599 Canis lupus familiaris
100514084 Sus scrofa
734314 Xenopus laevis
100174603 Pongo abelii
406704 Danio rerio
27965 Mus musculus
300791 Rattus norvegicus
Selected quality suppliers for SPG21 Proteins (SPG21)
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