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The protein encoded by SPHK1 catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Additionally we are shipping Sphingosine Kinase 1 Proteins (13) and Sphingosine Kinase 1 Kits (8) and many more products for this protein.
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Human Polyclonal SPHK1 Primary Antibody for IHC (p), WB - ABIN391346
Nayak, Huo, Kwang, Pushparaj, Kumar, Ling, Dheen: Sphingosine kinase 1 regulates the expression of proinflammatory cytokines and nitric oxide in activated microglia. in Neuroscience 2010
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Human Polyclonal SPHK1 Primary Antibody for EIA, IHC (p) - ABIN359438
Li, Yu, Xia, Zhang, Weng, Zheng, Kong, Hu, Zeng, Zeng, Li, Li, Song: Sphingosine kinase 1 is associated with gastric cancer progression and poor survival of patients. in Clinical cancer research : an official journal of the American Association for Cancer Research 2009
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Human Polyclonal SPHK1 Primary Antibody for EIA, WB - ABIN359437
Nava, Lacana, Poulton, Liu, Sugiura, Kono, Milstien, Kohama, Spiegel: Functional characterization of human sphingosine kinase-1. in FEBS letters 2000
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Human Polyclonal SPHK1 Primary Antibody for EIA, WB - ABIN359439
Ota, Suzuki, Nishikawa, Otsuki, Sugiyama, Irie, Wakamatsu, Hayashi, Sato, Nagai, Kimura, Makita, Sekine, Obayashi, Nishi, Shibahara, Tanaka, Ishii, Yamamoto, Saito, Kawai, Isono, Nakamura, Nagahari et al.: Complete sequencing and characterization of 21,243 full-length human cDNAs. ... in Nature genetics 2003
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Human Polyclonal SPHK1 Primary Antibody for ELISA, WB - ABIN314839
Igarashi, Okada, Hayashi, Fujita, Jahangeer, Nakamura: Sphingosine kinase 2 is a nuclear protein and inhibits DNA synthesis. in The Journal of biological chemistry 2003
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Human Polyclonal SPHK1 Primary Antibody for WB - ABIN391345
Hayashi, Nakagami, Takami, Koriyama, Mori, Tamai, Sun, Nagao, Morishita, Kaneda: FHL-2 suppresses VEGF-induced phosphatidylinositol 3-kinase/Akt activation via interaction with sphingosine kinase-1. in Arteriosclerosis, thrombosis, and vascular biology 2009
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Mouse (Murine) Polyclonal SPHK1 Primary Antibody for WB - ABIN4620349
Kihara, Ikeda, Kariya, Lee, Lee, Igarashi: Sphingosine-1-phosphate lyase is involved in the differentiation of F9 embryonal carcinoma cells to primitive endoderm. in The Journal of biological chemistry 2003
Human Polyclonal SPHK1 Primary Antibody for EIA, WB - ABIN782886
Kohama, Olivera, Edsall, Nagiec, Dickson, Spiegel: Molecular cloning and functional characterization of murine sphingosine kinase. in The Journal of biological chemistry 1998
Human Polyclonal SPHK1 Primary Antibody for ELISA, WB - ABIN308402
Kase, Hattori, Jojima, Okayasu, Tomizawa, Suzuki, Banba, Monden, Satoh, Akimoto, Kasai: Globular adiponectin induces adhesion molecule expression through the sphingosine kinase pathway in vascular endothelial cells. in Life sciences 2007
Sk1 and Sk2 (show KCNN2 Antibodies) are not redundant in biological function and are essential for diverse physiological functions in Drosophila
SPHK/phyto-S1P (show MBTPS1 Antibodies) and PLDalpha1A are co-dependent in amplification of response to ABA, mediating stomatal closure in Arabidopsis.
Sphingosine kinase 1 phosphorylates sphingosine-1-phosphate and phytosphingosine-1-phosphate, and is coordinately regulated with sphingosine-1-phosphate phosphatase.
Melatonin administration significantly inhibited those changes and induced a decreased immunoreactivity for rabbit hemorrhagic disease virus VP60 antigen in the liver. Results obtained indicate that the SphK1/S1P (show MBTPS1 Antibodies) system activates in parallel to viral replication and the inflammatory process induced by the virus.
demonstrated the roles played by miR (show MLXIP Antibodies)-144-3p and FN1 (show FN1 Antibodies) in mediating the oncogenic function of SphK1, which enhanced the understanding of the etiology of PTC (show F9 Antibodies)
SphK1 is associated with the proliferation and invasiveness of CRC (show CALR Antibodies) cells and the SphK1 gene may contribute to a novel therapeutic approach against CRC (show CALR Antibodies).
The levels of SphK1 were significantly increased in triple-negative breast cancer patients compared with normal controls. SphK1 knockdown with siRNA decreased TNBC cell proliferation and inhibited cell migration/invasion, suggesting that SphK1 has an important role in TNBC.
SPHK1 mRNA is up-regulation in colorectal cancer.
Found that upregulation of SphK1 expression in the stiff substrate is dominant in metastatic cancer cells but not in primary cancer cells. These results suggest that alterations in the mechanical environment of the extracellular matrix surrounding the tumor cells actively regulate cellular properties such as secretion, which in turn, may contribute to cancer progression.
In conclusion, these data suggested that HuR (show ELAVL1 Antibodies) bound to SphK1 mRNA and played a crucial role in TGF-beta1 (show TGFB1 Antibodies)-induced hepatic stellate cell activation.
low oxLDL concentration triggers sprouting angiogenesis that involves ROS (show ROS1 Antibodies)-induced activation of the neutral sphingomyelinase-2 (show SMPD3 Antibodies)/sphingosine kinase-1 pathway, and is effectively inhibited by GW4869.
SphK1 expression is functionally associated to cellular proliferation, apoptosis, invasion and mitotane sensitivity of adrenocortical carcinoma.
Data show that long non-coding RNA HULC promotes tumor angiogenesis in liver cancer through microRNA miR (show MLXIP Antibodies)-107/E2F1 transcription factor (E2F1 (show E2F1 Antibodies))/sphingosine kinase 1 (SPHK1) signaling.
High SPHK1 expression is associated with ovarian cancer.
These findings suggest that the inhibitory effect of these plant extracts on the activation of AGEs/RAGE (show AGER Antibodies)/SphK1 signaling pathway in db/db (show LEPR Antibodies) diabetic mice kidney is a novel mechanism by which they exert renoprotective effects in diabetic nephropathy.
Keratinocyte-specific deletion of Traf2 (show TRAF2 Antibodies), but not Sphk1 deficiency, disrupted TNF (show TNF Antibodies) mediated NF-kappaB (show NFKB1 Antibodies) and MAP kinase (show MAPK1 Antibodies) signalling and caused epidermal hyperplasia and psoriatic skin inflammation.
SphK1 dependent PKC-delta (show PKCd Antibodies) activation plays an important role in promoting NF-kappaB (show NFKB1 Antibodies) activation and inflammatory response in acute liver failure, and inhibition of PKC-delta (show PKCd Antibodies) activation might be a potential therapeutic strategy for this disease.
Inhibition of SphK1 ameliorates drug-induced acute liver failure by reducing HMGB1 (show HMGB1 Antibodies) cytoplasmic translocation in liver cells.
Collectively, our results demonstrate that PF-543 exerts potent anti-CRC (show SCRIB Antibodies) activity in vitro and in vivo.
transient receptor potential channel 1 suppression of basal sphingosine kinase 1 activity enables endothelial cell-barrier destabilization by edemagenic agonists
Based on these findings, the authors propose new roles for SK1 in affecting innate responses that regulate susceptibility to dengue virus infection.
Together, these results suggest that alpha-MSH alleviates Dex-induced damages to cultured osteoblasts through activating MC4R (show MC4R Antibodies)-SphK1 signaling.
The study demonstrates a new pathway connecting SphK1 and PPARgamma (show PPARG Antibodies) involved in the pathogenesis of hepatocellular steatosis.
Inhibition of SK1 attenuates the second phase of transmembrane Calcium influx.
The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, sphingosine kinase 1
, sphingosine kinase I
, SK 1
, SPK 1