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The protein encoded by SPHK1 catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Additionally we are shipping Sphingosine Kinase 1 Proteins (15) and Sphingosine Kinase 1 Kits (10) and many more products for this protein.
Showing 10 out of 204 products:
Human Polyclonal SPHK1 Primary Antibody for IHC (p), WB - ABIN391346
Nayak, Huo, Kwang, Pushparaj, Kumar, Ling, Dheen: Sphingosine kinase 1 regulates the expression of proinflammatory cytokines and nitric oxide in activated microglia. in Neuroscience 2010
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Human Polyclonal SPHK1 Primary Antibody for EIA, WB - ABIN359437
Nava, Lacana, Poulton, Liu, Sugiura, Kono, Milstien, Kohama, Spiegel: Functional characterization of human sphingosine kinase-1. in FEBS letters 2000
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Human Polyclonal SPHK1 Primary Antibody for EIA, WB - ABIN359439
Ota, Suzuki, Nishikawa, Otsuki, Sugiyama, Irie, Wakamatsu, Hayashi, Sato, Nagai, Kimura, Makita, Sekine, Obayashi, Nishi, Shibahara, Tanaka, Ishii, Yamamoto, Saito, Kawai, Isono, Nakamura, Nagahari et al.: Complete sequencing and characterization of 21,243 full-length human cDNAs. ... in Nature genetics 2003
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Human Polyclonal SPHK1 Primary Antibody for WB - ABIN391345
Hayashi, Nakagami, Takami, Koriyama, Mori, Tamai, Sun, Nagao, Morishita, Kaneda: FHL-2 suppresses VEGF-induced phosphatidylinositol 3-kinase/Akt activation via interaction with sphingosine kinase-1. in Arteriosclerosis, thrombosis, and vascular biology 2009
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Human Polyclonal SPHK1 Primary Antibody for IF (p), IHC (p) - ABIN748598
Tani, Tabuchi, Hara: Hair Cell Loss Induced by Sphingosine and a Sphingosine Kinase Inhibitor in the Rat Cochlea. in Neurotoxicity research 2016
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Human Polyclonal SPHK1 Primary Antibody for ELISA, WB - ABIN314839
Igarashi, Okada, Hayashi, Fujita, Jahangeer, Nakamura: Sphingosine kinase 2 is a nuclear protein and inhibits DNA synthesis. in The Journal of biological chemistry 2003
Show all 2 references for 314839
Human Polyclonal SPHK1 Primary Antibody for WB - ABIN391347
Di, Kawamura, Gao, Tang, Berdyshev, Vogel, Zhao, Sharma, Bachmaier, Xu, Malik: A novel function of sphingosine kinase 1 suppression of JNK activity in preventing inflammation and injury. in The Journal of biological chemistry 2010
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Human Polyclonal SPHK1 Primary Antibody for EIA, WB - ABIN782886
Kohama, Olivera, Edsall, Nagiec, Dickson, Spiegel: Molecular cloning and functional characterization of murine sphingosine kinase. in The Journal of biological chemistry 1998
Human Polyclonal SPHK1 Primary Antibody for ELISA, WB - ABIN308402
Kase, Hattori, Jojima, Okayasu, Tomizawa, Suzuki, Banba, Monden, Satoh, Akimoto, Kasai: Globular adiponectin induces adhesion molecule expression through the sphingosine kinase pathway in vascular endothelial cells. in Life sciences 2007
Mouse (Murine) Polyclonal SPHK1 Primary Antibody for WB - ABIN4620349
Kihara, Ikeda, Kariya, Lee, Lee, Igarashi: Sphingosine-1-phosphate lyase is involved in the differentiation of F9 embryonal carcinoma cells to primitive endoderm. in The Journal of biological chemistry 2003
Sk1 and Sk2 (show KCNN2 Antibodies) are not redundant in biological function and are essential for diverse physiological functions in Drosophila
SPHK/phyto-S1P (show MBTPS1 Antibodies) and PLDalpha1A are co-dependent in amplification of response to ABA, mediating stomatal closure in Arabidopsis.
Sphingosine kinase 1 phosphorylates sphingosine-1-phosphate and phytosphingosine-1-phosphate, and is coordinately regulated with sphingosine-1-phosphate phosphatase.
Melatonin administration significantly inhibited those changes and induced a decreased immunoreactivity for rabbit hemorrhagic disease virus VP60 antigen in the liver. Results obtained indicate that the SphK1/S1P (show MBTPS1 Antibodies) system activates in parallel to viral replication and the inflammatory process induced by the virus.
High SPHK1 expression is associated with hepatocellular carcinoma.
we identified sphingosine kinase 1 (SPHK1) as a novel target of miR (show MLXIP Antibodies)-506, the expression of which inhibited the SPHK1/Akt (show AKT1 Antibodies)/NF-kappaB (show NFKB1 Antibodies) signaling pathway, which is activated in pancreatic cancer. High SPHK1 expression was significantly associated with poor survival in a large cohort of pancreatic cancer specimens.
Inhibition of SPHK1 in human acute myeloid leukemia (show BCL11A Antibodies) cells induces MCL1 (show MCL1 Antibodies) degradation and caspase (show CASP3 Antibodies)-dependent cell death.
The analysis suggests that the catalytic function and regulation of SPHK1 and SPHK2 (show SPHK2 Antibodies) might be dependent on their conformational mobility. (Review)
our data suggest that SphK1 modulates the expression of EMT (show ITK Antibodies)-related markers and cell migration by regulating the expression of p-FAK (show PTK2 Antibodies) in CRC (show CALR Antibodies) cells. Thus, SphK1 may play a functional role in mediating the EMT (show ITK Antibodies) process in CRC (show CALR Antibodies).
These results highlight the importance of sphingosine and its conversion to sphingosine-1-phosphate by SphK1 in endocytic membrane trafficking.
By simulating therapeutic strategies that target multiple nodes of the pathway such as Raf and SphK1, we conclude that combination therapy should be much more effective in blocking VEGF signaling to EKR1/2. The model has important implications for interventions that target signaling pathways in angiogenesis relevant to cancer, vascular diseases, and wound healing.
SphK1 is regulated by PDGF (show PDGFA Antibodies)-BB in pulmonary artery smooth muscle cells via the transcription factor Egr-1 (show EGR1 Antibodies), promoting cell proliferation.
Melatonin-treated cells also exhibited an inhibition of the SphK1/S1P (show MBTPS1 Antibodies) axis. Antifibrogenic effect of SphK1 inhibition was confirmed by treatment of LX2 cells with PF543. Abrogation of the lipid signaling pathway by the indole reveals novel molecular pathways that may account for the protective effect of melatonin in liver fibrogenesis.
demonstrated the roles played by miR (show MLXIP Antibodies)-144-3p and FN1 (show FN1 Antibodies) in mediating the oncogenic function of SphK1, which enhanced the understanding of the etiology of PTC (show F9 Antibodies)
donor islets from mice deficient in Sphk1 KO contain a reduced number of resident intraislet vascular endothelial cells. The main product of Sphk1, sphingosine-1-phosphate, controls the migration of intraislet endothelial cells in vitro. In vivo, Sphk1 knockout islets have an impaired ability to cure diabetes compared with wild-type controls.
Sphingosine kinase 1 worsens pancreatic cancer peritoneal carcinomatosis by stimulation of proliferation of cancer cells.
Melatonin-treated cells also exhibited an inhibition of the SphK1/S1P (show S1PR1 Antibodies) axis. Antifibrogenic effect of SphK1 inhibition was confirmed by treatment of LX2 cells with PF543. Abrogation of the lipid signaling pathway by the indole reveals novel molecular pathways that may account for the protective effect of melatonin in liver fibrogenesis.
These findings suggest that the inhibitory effect of these plant extracts on the activation of AGEs/RAGE (show AGER Antibodies)/SphK1 signaling pathway in db/db (show LEPR Antibodies) diabetic mice kidney is a novel mechanism by which they exert renoprotective effects in diabetic nephropathy.
Keratinocyte-specific deletion of Traf2 (show TRAF2 Antibodies), but not Sphk1 deficiency, disrupted TNF (show TNF Antibodies) mediated NF-kappaB (show NFKB1 Antibodies) and MAP kinase (show MAPK1 Antibodies) signalling and caused epidermal hyperplasia and psoriatic skin inflammation.
SphK1 dependent PKC-delta (show PKCd Antibodies) activation plays an important role in promoting NF-kappaB (show NFKB1 Antibodies) activation and inflammatory response in acute liver failure, and inhibition of PKC-delta (show PKCd Antibodies) activation might be a potential therapeutic strategy for this disease.
Inhibition of SphK1 ameliorates drug-induced acute liver failure by reducing HMGB1 (show HMGB1 Antibodies) cytoplasmic translocation in liver cells.
Collectively, our results demonstrate that PF-543 exerts potent anti-CRC (show SCRIB Antibodies) activity in vitro and in vivo.
transient receptor potential channel 1 suppression of basal sphingosine kinase 1 activity enables endothelial cell-barrier destabilization by edemagenic agonists
The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, sphingosine kinase 1
, sphingosine kinase I
, SK 1
, SPK 1