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Signaling adapter that couples activated growth factor receptors to signaling pathways.
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In mice and humans, reduced p66Shc levels protect from obesity, but not from ectopic fat accumulation, glucose intolerance and insulin (show INS Antibodies) resistance.
p53 (show TP53 Antibodies)-dependent augmentation of p66(Shc) expression and function represents a key signalling response contributing to beta cell apoptosis under conditions of lipotoxicity
Silencing of p66(Shc) restored insulin (show INS Antibodies) response via IRS-1 (show IRS1 Antibodies)/Akt (show AKT1 Antibodies)/eNOS (show NOS3 Antibodies) pathway. Its knockdown in endothelial cells from Ob/Ob mice lessened ROS (show ROS1 Antibodies) production, FFA oxidation, and dysregulation of redox-sensitive pathways.
These data identify multiple modes by which ShcA can fine-tune the development of early thymocytes, including a previously unappreciated ShcA-c-Abl axis that regulates thymocyte proliferation.
PKCbeta2 inhibition protects mice from gut (show GUSB Antibodies) ischemia-reperfusion injury by suppressing the adaptor p66(Shc)-mediated oxidative stress and subsequent apoptosis.
Endothelial function in cerebral arteries is heavily impaired by aging and is partly mediated by the p66Shc gene.
ShcA interacts with crucial proteins and pathways that link Z-disk and costamere during heart development
these data identify an important role for the adapter protein (show GRB10 Antibodies) ShcA in later stages of thymic T cell development and in peripheral T cell-dependent events.
CRIF1 (show GADD45GIP1 Antibodies) knockdown partially induces endothelial activation via increased ROS (show ROS1 Antibodies) production and phosphorylation of p66shc
The regulation of p66shc-related antioxidative and antiapoptotic factors contributes to protection from ischemia-reperfusion injury.
Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis (By similarity). Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p47Shc and isoform p52Shc, once phosphorylated, couple activated receptor kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p47Shc and isoform p52 may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span.
SH2 domain protein C1
, SHC-transforming protein 1
, SHC-transforming protein A
, src homology 2 domain-containing-transforming protein C1