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SHC1 antibody
SHC1
Reactivity: Human, Mouse, Rat
IHC, IF
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-SHC1 Antibody
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Target
See all SHC1 Antibodies
SHC1
(SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1))
Reactivity
All reactivities for SHC1 antibodies
Human, Mouse, Rat
Host
All hosts for SHC1 antibodies
Rabbit
Clonality
All clonalities for SHC1 antibodies
Polyclonal
Conjugate
All conjugates for SHC1 antibodies
This SHC1 antibody is un-conjugated
Application
All applications for SHC1 antibodies
Immunohistochemistry (IHC), Immunofluorescence (IF)
Characteristics
Polyclonal Antibody
Purification
Affinity purification
Immunogen
A synthetic peptide of human SHC1
Isotype
IgG
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Discover our top product SHC1 Primary Antibody
Alternatives
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Application Details
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Application Notes
IHC 1:50-1:200 IF 1:50-1:200
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1 mg/mL
Buffer
PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
Store at -20°C. Avoid freeze / thaw cycles.
Target Details for SHC1
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Target
SHC1
(SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1))
Alternative Name
SHC1 (SHC1 Products )
Synonyms
SHC1 antibody, SHC antibody, SHCA antibody, P66shc antibody, si:dkey-246i14.4 antibody, wu:fc10h03 antibody, shc antibody, p66shc antibody, Shc antibody, ShcA antibody, p66 antibody, SHC adaptor protein 1 antibody, Shc1p antibody, squalene--hopene cyclase antibody, SHC (Src homology 2 domain containing) transforming protein 1 antibody, SHC (Src homology 2 domain containing) transforming protein 1 L homeolog antibody, src homology 2 domain-containing transforming protein C1 antibody, SHC1 antibody, shc1 antibody, Shc1 antibody, shc1.L antibody
Background
This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene.
Gene ID
6464
UniProt
P29353
Pathways
RTK Signaling , TCR Signaling , Fc-epsilon Receptor Signaling Pathway , EGFR Signaling Pathway , Neurotrophin Signaling Pathway , ER-Nucleus Signaling , Signaling Events mediated by VEGFR1 and VEGFR2
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