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SOAT2 is a member of a small family of acyl coenzyme A:cholesterol acyltransferases. Additionally we are shipping SOAT2 Antibodies (24) and many more products for this protein.
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TG-interacting factor 1 (Tgif1 (show TGIF1 Proteins)) is an important repressor of SOAT2 gene expression.
CDX2 (show CDX2 Proteins), a known positive regulator of hepatocyte differentiation, was regulated by miR (show MLXIP Proteins)-181d and directly activated SOAT2 gene expression.
We found a new single-nucleotide polymorphism (SNP; a point mutation in intron 1, IVS1 -8 G-->C) in the ACAT-2 gene. Our data suggest that the ACAT-2 gene may not affect lipid levels in humans.
Fully differentiated macrophages express ACAT2 (show ACAT2 Proteins) in addition to ACAT1 (show ACAT1 Proteins) under various pathologic conditions.
ACAT-1 transcripts predominate in human liver and ACAT-2 transcripts predominate in human duodenum and support the notion that ACAT-2 has an important regulatory role in liver and intestine.
increasing DGAT1, ACAT1, or ACAT2 expression stimulates the assembly and secretion of VLDL from liver cells
ACAT2 provided the major cholesterol-esterifying activity in 3 of 4 human liver samples.
transcription factors hepatic nuclear factor 1 (HNF1)alpha (show HNF1A Proteins) and beta play an important part in the regulation of the ACAT2 (show ACAT2 Proteins) promoter
The structural features of various sterols as substrates and/or activators of ACAT1 and ACAT2 in vitro are reported.
Serum-induced depletion of cellular cholesterol available for esterification by ACAT (show SOAT1 Proteins) was a strong, independent predictor of major adverse cardiovascular events and death.
These studies demonstrate that SOAT2 is a negative regulator of LXR-stimulated fecal neutral sterol loss in mice.
Hepatic knockdown of SOAT2 in apoB100 (show APOB Proteins)-only, LDLr (show LDLR Proteins)(-/-) mice resulted in remodeling of aortic atherosclerotic lesions into a stable phenotype, suggesting SOAT2 is a viable target for the treatment of atherosclerosis.
SOAT2 causes hepatic cholesterol to be swiftly mobilized and packaged onto nascent lipoproteins that feed cholesterol into the TICE pathway for fecal excretion.
effect the loss of SOAT2 function has on tissue esterified cholesterol sequestration in lysosomal acid lipase (show LIPA Proteins)-deficient mice in a model of cholesteryl ester storage disease
Aortic atherosclerosis development was significantly lower in SOAT2 knock-out mice.
ACAT2 increases cholesterol absorption efficiency by providing cholesterol esters for chylomicron transport, but 1 copy of the Acat2 gene, providing approximately 50% of ACAT2 mRNA and enzyme activity, was as effective as 2 copies in promoting cholesterol absorption.
ACAT2-derived cholesterol esters have a crucial role in the development of atherosclerosis in mice
ACAT2 displays a greater capacity than ACAT1 (show SOAT1 Proteins) to differentiate cholesterol from sitosterol
ACAT2-derived cholesteryl ester is the predominant atherogenic lipid in blood.
ACAT2 deficiency limits cholesterol absorption. Extent it impacts hepatic cholesterol homeostasis depends on cholesterol intake. Loss of ACAT2 activity may result in unesterified cholesterol being absorbed via ABCA1 (show ABCA1 Proteins)-mediated basolateral efflux pathway.
This gene is a member of a small family of acyl coenzyme A:cholesterol acyltransferases. The gene encodes a membrane-bound enzyme localized in the endoplasmic reticulum that produces intracellular cholesterol esters from long-chain fatty acyl CoA and cholesterol. The cholesterol esters are then stored as cytoplasmic lipid droplets inside the cell. The enzyme is implicated in cholesterol absorption in the intestine and in the assembly and secretion of apolipoprotein B-containing lipoproteins such as very low density lipoprotein (VLDL). Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.
sterol O-acyltransferase 2
, acyl coenzyme A cholesterol acyltransferase 2
, acyl Co-A: cholesterol acyltransferase 2
, acyl coenzyme A:cholesterol acyltransferase 2
, acyl-CoA:cholesterol acyltransferase 2
, acyl-coenzyme A:cholesterol acyltransferase 2
, cholesterol acyltransferase 2
, acyl-CoA:cholesterol acyltransferase