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Superoxide Dismutase 2, Mitochondrial Proteins (SOD2)

SOD2 is a member of the iron/manganese superoxide dismutase family. Additionally we are shipping Superoxide Dismutase 2, Mitochondrial Antibodies (256) and Superoxide Dismutase 2, Mitochondrial Kits (51) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SOD2 6648 P04179
SOD2 20656 P09671
SOD2 24787 P07895
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Top Superoxide Dismutase 2, Mitochondrial Proteins at antibodies-online.com

Showing 10 out of 47 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$286.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 16 Days
$382.80
Details
HOST_Escherichia coli (E. coli) Human His tag   100 μg Log in to see 3 to 4 Days
$910.80
Details
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 11 to 13 Days
$492.80
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$968.00
Details
HOST_Escherichia coli (E. coli) Rat His tag   100 μg Log in to see 11 to 13 Days
$563.20
Details
Yeast Branchiostoma floridae His tag   1 mg Log in to see 56 to 66 Days
$2,311.83
Details

SOD2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Rat (Rattus) ,

Top referenced Superoxide Dismutase 2, Mitochondrial Proteins

  1. Human SOD2 Protein expressed in Escherichia coli (E. coli) - ABIN666966 : MacMillan-Crow, Thompson: Tyrosine modifications and inactivation of active site manganese superoxide dismutase mutant (Y34F) by peroxynitrite. in Archives of biochemistry and biophysics 1999 (PubMed)
    Show all 2 references for ABIN666966

  2. Human SOD2 Protein expressed in Escherichia coli (E. coli) - ABIN1686709 : Adachi, Ohta, Yamada, Futenma, Kato, Hirano: Quantitative analysis of extracellular-superoxide dismutase in serum and urine by ELISA with monoclonal antibody. in Clinica chimica acta; international journal of clinical chemistry 1993 (PubMed)
    Show all 2 references for ABIN1686709

  3. Human SOD2 Protein expressed in Wheat germ - ABIN1320944 : Yang, Xiao, Zhang, Li, Zhang, Li, Chen, Zhu, Sun, Liu, Chen: Identification of tumor antigens in human lung squamous carcinoma by serological proteome analysis. in Journal of proteome research 2007 (PubMed)

  4. Human SOD2 Protein expressed in Escherichia coli (E. coli) - ABIN2005301 : Zelko, Mariani, Folz: Superoxide dismutase multigene family: a comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression. in Free radical biology & medicine 2002 (PubMed)

More Proteins for Superoxide Dismutase 2, Mitochondrial (SOD2) Interaction Partners

Rabbit Superoxide Dismutase 2, Mitochondrial (SOD2) interaction partners

  1. Prion (show PRNP Proteins) propagation exacerbates an apoptotic pathway whereby mitochondrial dysfunction follows mislocalisation of SOD2 to cytosolic caspases permitting its degradation.

Fruit Fly (Drosophila melanogaster) Superoxide Dismutase 2, Mitochondrial (SOD2) interaction partners

  1. Depletion of superoxide dismutases promotes muscular and neuronal ROS (show ROS1 Proteins) accumulation which may have a significant effect on age-dependent impairment of the Drosophila adults.

  2. Paraquat exposure, but not Sod2 knockdown, resulted in increased carbonylated protein relative abundance.

  3. The functional SOD1 (show SOD1 Proteins) and SOD2 genes knockout and their overexpression in neurons and glial tissue increase the sensitivity of Drosophila melanogaster to oxidative stress conditions.

  4. ocytes lacking maternal SOD2 protein develop into adults just like normal SOD2-containing oocytes suggesting that maternal SOD2-mediated protection against mitochondrial ROS (show ROS1 Proteins) is not essential for oocyte viability

  5. Muscles appear to be more sensitive to superoxide attack relative to the neurons and such overt phenotypes observed in SOD2-deficient animals can be directly attributed to the muscle.

  6. Overexpression of Cu,ZnSOD (show SOD1 Proteins) and MnSOD in transgenic Drosophila.

  7. Ablation of mitochondrial SOD2 through expression of a GAL4 (show LGALS4 Proteins)-regulated, inverted-repeat Sod2 RNA-interference causes increased endogenous oxidative stress, loss of respiratory chain & TCA cycle components,& early-onset mortality in young adults.

  8. Effects of overexpression of copper-zinc and manganese superoxide dismutases, catalase, and thioredoxin reductase genes on longevity.

  9. The chromosomal deficiency Df(2R)017 significantly up-regulated MnSOD mRNA by 1.7-fold. Deficiency in four other genomic intervals, Df(1)ct-J4, Df(2L)BSC4, Df(3L)66C-G28 and Df(3R)Scr, down-regulated MnSOD expression.

  10. SOD1 (show SOD1 Proteins) and SOD2 provide independent protection to compartment-specific protein iron-sulfur clusters against attack by superoxide generated under oxidative stress

Human Superoxide Dismutase 2, Mitochondrial (SOD2) interaction partners

  1. By inhibiting mTOR (show FRAP1 Proteins) and MnSOD, we confirmed that rapamycin functioned through the mTOR (show FRAP1 Proteins)/MnSOD/reactive oxygen species (ROS (show ROS1 Proteins)) signaling pathway, and the existence of Akt (show AKT1 Proteins) governed the rapamycininduced asymmetric division

  2. miR (show MLXIP Proteins)-140-5p at least partly targets Dnmt1 (show DNMT1 Proteins) and regulates SOD2 expression to inhibit proliferation and promote apoptosis and differentiation of HPASMCs in hypoxia

  3. The results indicate that common variants in MnSOD and eNOS increased the risk of T2DM in the Chinese Han population.

  4. SOD2 genetic variant associated with treatment-related ototoxicity in cisplatin-treated pediatric medulloblastoma

  5. MnSOD Val-9Ala gene polymorphism has a positive association with the risk for aggressive periodontitis.

  6. Although T allele of the SOD2 rs4880 SNP gene (rs4880-T) is not an independent risk for aMCI or AD, this allele increases the risk to aMCI patients carrying at least one APOEepsilon4 allele.

  7. Thus these findings suggest that the three variants of ADH1C, MnSOD and GSTM1 can be used to identify individuals who are at high risk to develop ALD and may be helpful in proper management of Indian alcoholics

  8. SOD2 single nucleotide polymorphisms and occurrence of osteoporosis in Asian Indians

  9. Data show that increased microRNA miR (show MLXIP Proteins)-301a expression is associated with decreased manganese superoxide dismutase (MnSOD) expression in pancreatic ductal adenocarcinoma (PDAC) specimens.

  10. The Mn-SOD expression was more frequently present in specimens with severe and moderate inflammation of gastric mucosa than in those with normal mucosa.

Pig (Porcine) Superoxide Dismutase 2, Mitochondrial (SOD2) interaction partners

  1. show that ischemia markedly potentiated the expression of arginase-1 (show ARG1 Proteins), and also induced the SOD2 in the wound tissue.

Cow (Bovine) Superoxide Dismutase 2, Mitochondrial (SOD2) interaction partners

  1. Exposure to follicular fluid transiently increased the transcript levels of IL8 (show IL8 Proteins) and PTGS2 (show PTGS2 Proteins), and decreased the expression of SOD2, GPX3 (show GPX3 Proteins), DAB2 (show DAB2 Proteins), and NR3C1 (show NR3C1 Proteins). TNF (show TNF Proteins) and IL6 (show IL6 Proteins) levels were also decreased while those of NAMPT (show NAMPT Proteins) were unaffected.

  2. Data suggest that during ectogenesis of blastocysts infected with bovine Herpesvirus type 5, expression of SOD2 (Mn) remains high indicating intense mitochondrial activity; this effect may be involved in inhibition of apoptosis in infected embryos.

  3. expression profile of SOD2 in follicles: oocytes (SOD2 restricted to ooplasm); cumulus cells (expressed some SOD2); follicular fluid (small follicles show increased amounts of SOD2 in comparison with large follicles)

  4. Shear stress influences spatial variations in vascular Mn-SOD expression with implications for LDL nitration.

  5. The expression of SOD1 (show SOD1 Proteins) and SOD2 through the course of the estrous cycle is reported.

  6. Heart mitochondrial nucleoids contained SOD2, aortic endothelial cell mitochondrial nucleoids did not

Mouse (Murine) Superoxide Dismutase 2, Mitochondrial (SOD2) interaction partners

  1. The results indicated that the inconsistency between Mn SOD expression and its activity might contribute to the development of recognition dysfunction induced by chronic Al overload.

  2. Evidence for a tumor suppressive role of MnSOD in liver, where the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) and hypoxia pathway may be crucial elements.

  3. SOD2 overexpression in cardiomyocytes enhances mitochondrial function and metabolic vasodilation, leading to a phenotype of supernormal cardiac function.

  4. Pluripotency transcription factors Nanog (show NANOG Proteins) and Oct4 (show POU5F1 Proteins) positively modulate Sod2 gene transcription in induced pluripotent stem cells.

  5. Data show that mechanical overloading elevated mitochondrial superoxide generation and downregulated superoxide dismutase 2 (Sod2) expression in knee chondrocytes.

  6. Data show that tissue specific deletion of manganese superoxide dismutase (Sod2) caused elevated signs of oxidative stress, retinal pigment epithelium (RPE (show RPE Proteins)) dysfunction and showed some key features of age-related macular degeneration (AMD (show AMD1 Proteins)). .

  7. Mutated myocilin (show MYOC Proteins) and heterozygous Sod2 deficiency act synergistically in a mouse model of open-angle glaucoma

  8. Data indicate sirtuin 3 (Sirt3 (show SIRT3 Proteins))-manganese superoxide dismutase (MnSOD) axis as a negative component in nicotine-induced mitochondrial oxidative stress and mitochondrial DNA (mtDNA) damage.

  9. The results demonstrate a unique CDK4 (show CDK4 Proteins)-mediated mitochondrial communication that allows cells to sense environmental genotoxic stress and boost mitochondrial homeostasis by enhancing phosphorylation and activation of MnSOD.

  10. Data show that the lactate level was increased more in manganese superoxide dismutase deficiency Sod2+/- tissue.

Superoxide Dismutase 2, Mitochondrial (SOD2) Protein Profile

Protein Summary

This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Gene names and symbols associated with SOD2

  • MnSOD (BDBG_07234)
  • MnSOD (LOC100101896)
  • manganese superoxide dismutase (GSVIVT00029451001)
  • superoxide dismutase 2, mitochondrial (Sod2)
  • superoxide dismutase 2, mitochondrial (sod2)
  • Mn superoxide dismutase (Sod2)
  • Mn superoxide dismutase (LbMnSOD4)
  • superoxide dismutase 2, mitochondrial (SOD2)
  • superoxide dismutase 2 (LOC100282741)
  • manganese superoxide dismutase (SOD-2)
  • Superoxide dismutase 2 (Mn) (Sod2)
  • cb463 protein
  • CG8905 protein
  • Dmel\\CG8905 protein
  • dSOD2 protein
  • GB14346 protein
  • IPOB protein
  • LOC100101896 protein
  • MGC88869 protein
  • Mito SOD protein
  • mitSOD2 protein
  • Mn-SOD protein
  • Mn-SOD2 protein
  • mnSOD protein
  • Mn SOD protein
  • MnSODII protein
  • Mn[2+]SOD protein
  • MVCD6 protein
  • SOD protein
  • Sod-2 protein
  • SOD2 protein
  • wu:fj33b01 protein
  • zgc:73051 protein

Protein level used designations for SOD2

MnSOD , manganese superoxide dismutase , Mn Sod , Mn superoxide dismutase , superoxide dismutase 2, mitochondrial , superoxide dismutase [Mn], mitochondrial , GRMZM5G891739 , CG8905-PA , Mn-superoxide dismutase , Sod2-PA , manganese-SOD , mitochodnrial SOD , mitochondrial Mn-superoxide dismutase 2 , mitochondrial MnSOD , mitochondrial superoxide dismutase 2 , superoxide dismutase , superoxide dismutase 2 , superoxide dismutase 2 (Mn) , superoxide dismutase-2 , indophenoloxidase B , manganese-containing superoxide dismutase , mangano-superoxide dismutase , superoxide dismutase (Mn type) , manganous superoxide dismutase , manganese SOD , Superoxide dimutase 2, mitochondrial , Mn-SOD , sod(Mn)

GENE ID SPECIES
8502558 Ajellomyces dermatitidis SLH14081
100101896 Glycine max
100233137 Vitis vinifera
410082 Apis mellifera
448200 Xenopus (Silurana) tropicalis
692736 Bombyx mori
6074587 Laccaria bicolor S238N-H82
100174061 Pongo abelii
100282741 Zea mays
100009336 Oryctolagus cuniculus
36878 Drosophila melanogaster
6648 Homo sapiens
399216 Xenopus laevis
374042 Gallus gallus
476258 Canis lupus familiaris
100154319 Sus scrofa
281496 Bos taurus
780457 Ovis aries
20656 Mus musculus
24787 Rattus norvegicus
100135623 Cavia porcellus
335799 Danio rerio
574097 Macaca mulatta
449634 Pan troglodytes
100410185 Callithrix jacchus
100034223 Equus caballus
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