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SYMPK encodes a nuclear protein that functions in the regulation of polyadenylation and promotes gene expression. Additionally we are shipping Symplekin Proteins (4) and Symplekin Kits (2) and many more products for this protein.
Showing 10 out of 38 products:
Human Monoclonal SYMPK Primary Antibody for IHC (fro), WB - ABIN112237
Keon, Schäfer, Kuhn, Grund, Franke: Symplekin, a novel type of tight junction plaque protein. in The Journal of cell biology 1996
Show all 4 references for ABIN112237
Chicken Monoclonal SYMPK Primary Antibody for IF, IP - ABIN968084
Cordenonsi, DAtri, Hammar, Parry, Kendrick-Jones, Shore, Citi: Cingulin contains globular and coiled-coil domains and interacts with ZO-1, ZO-2, ZO-3, and myosin. in The Journal of cell biology 2000
Show all 2 references for ABIN968084
Cow (Bovine) Polyclonal SYMPK Primary Antibody for IHC, WB - ABIN2775623
Cao, Chang, Li, Cheng, Fan: Alteration of adhesion molecule expression and cellular polarity in hepatocellular carcinoma. in Histopathology 2007
Authors propose a model in which the core cleavage complex formation is mediated by CPSF73 (show CPSF3 Antibodies), CPSF100 (show CPSF2 Antibodies), and Symplekin C-termini, and the N-terminal region of Symplekin facilitates cotranscriptional 3' end processing of histone mRNAs.
This localization depends on the RNA binding protein ypsilon schachtel. CPSF-73 (show CPSF3 Antibodies) and a number of mRNAs are localized at this same site, suggesting that Symplekin participates in cytoplasmic polyadenylation at tricellular junctions.
Together, these data support the conclusion that the Symplekin HEAT domain serves as a scaffold for protein-protein interactions essential to the mRNA maturation process.
CPSF2 (show CPSF2 Antibodies) and SYMPK, are RBFOX2 (show RBM9 Antibodies) cofactors for both inclusion and exclusion of internal exons.
Symplekin interacts and co-localizes with both MOZ (show MYST3 Antibodies) and MLL (show MLL Antibodies) in immature hematopoietic cells. Its inhibition leads to a decrease of the HOXA9 (show HOXA9 Antibodies) protein level but not of Hoxa9 (show HOXA9 Antibodies) mRNA.
Symplekin expression regulates the assembly of tight junctions, thus helps to maintain the integrity of the epithelial monolayer and cellular polarity.
crystal structure at 2.4 A resolution of the amino-terminal domain (residues 30-340) of human symplekin in a ternary complex with the Pol II carboxy-terminal domain (CTD) Ser (show SIGLEC1 Antibodies) 5 phosphatase Ssu72 (show SSU72 Antibodies) and a CTD Ser (show SIGLEC1 Antibodies) 5 phosphopeptide
Symplekin supports faithful mitosis by contributing to the formation of a bipolar spindle apparatus. Depletion of symplekin attenuates microtubule polymerization as well as expression of the critical microtubule polymerization protein CKAP5 (TOGp (show CKAP5 Antibodies)).
Data show that claudin-2 (show CLDN2 Antibodies) expression was reduced following symplekin down-regulation, and siRNA-mediated claudin-2 (show CLDN2 Antibodies) down-regulation increased the transepithelial resistance and decreased cyclin D1 (show CCND1 Antibodies) expression and ZONAB (show CSDA Antibodies) nuclear localization.
symplekin has a role in HSF1 (show HSF1 Antibodies) modulation of Hsp70 (show HSP70 Antibodies) mRNA polyadenylation
The decreased expression of symplekin may be an early step in the transformation of hepatocytes, whereas alteration of the expression of adherens junctions and desmosomes may indicate more serious changes.
The symplekin/ZONAB (show CSDA Antibodies) complex inhibits intestinal cell differentiation by the repression of AML1/Runx1 (show RUNX1 Antibodies).
In Xenopus, symplekin interacts with the CPSF complex and the regulatory protein CPEB, (show CPEB1 Antibodies)and is re (show CPSF3 Antibodies)quired for polyadenylation of CPE-containing RNA
Here, we identify a new factor essential for polyadenylation, namely, symplekin, a CPEB and CPSF (show CPSF2 Antibodies) binding protein that serves as a scaffold upon which regulatory factors are assembled
This gene encodes a nuclear protein that functions in the regulation of polyadenylation and promotes gene expression. The protein forms a high-molecular weight complex with components of the polyadenylation machinery. It is thought to serve as a scaffold for recruiting regulatory factors to the polyadenylation complex. It also participates in 3'-end maturation of histone mRNAs, which do not undergo polyadenylation. The protein also localizes to the cytoplasmic plaques of tight junctions in some cell types.
, hepatocyte nuclear factor 3 gamma