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Sync encodes a member of the intermediate filament family which contains an N-terminal head domain, followed by a central coiled-coil region and a short C-terminal tail. Additionally we are shipping Syncoilin Kits (3) and Syncoilin Proteins (3) and many more products for this protein.
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in the liver, syncoilin is predominantly expressed by activated Hepatic stellate cells and displays very low-expression levels in other liver cell types, making it a good marker of activated Hepatic stellate cells.
A neuronal analysis of the syn (show PRPH Antibodies)coilin-null mouse (Sync(-/-)) revealed a reduced ability in accelerating treadmill and rotarod tests.
The data show that absence of alpha-dystrobrevin (show DTNA Antibodies) or desmin (show DES Antibodies) leads to dynamic changes in syncoilin that may compensate for, or participate in, different muscle myopathies.
Syncoilin may play a supportive role for desmin (show DES Antibodies) in the efficient coupling of mechanical stress between the myofibril and muscle fiber exterior.
A second viable syncoilin knockout model and highlights the importance of further investigations to determine the role of syncoilin in skeletal muscle.
Despite lacking an apparent structural role in striated (show NSDHL Antibodies) muscle, the three syncoilin isoforms are differentially and strongly upregulated during muscle regeneration and atrophy in C57BL/6 mice, possibly suggesting an atypical role for syncoilin in muscle.
Syncoilin modulates peripherin (show PRPH Antibodies) filament network formation.
The differences in human syncoilin and beta-synemin (show SYNM Antibodies) mRNA ratios between Duchenne muscular dystrophy (show DMD Antibodies) and normal muscles were not statistically significant
the result of this study raise the possibility that mutations in the gene encoding for syncoilin may underlie some forms of muscle disease.
This gene encodes a member of the intermediate filament family which contains an N-terminal head domain, followed by a central coiled-coil region and a short C-terminal tail. The protein is highly expressed in skeletal and cardiac muscle. The protein links the dystrophin associated protein complex (DAPC) to desmin filaments in muscle and may have a structural role in striated muscle. Multiple transcript variants encoding different isoforms have been found for this gene.
syncoilin intermediate filament 1
, intermediate filament protein syncoilin
, syncoilin, intermediate filament 1