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Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Additionally we are shipping SNCA Antibodies (542) and SNCA Proteins (68) and many more products for this protein.
Showing 10 out of 67 products:
Human SNCA ELISA Kit for Sandwich ELISA - ABIN414578
Alvarez-Erviti, Seow, Schapira, Gardiner, Sargent, Wood, Cooper: Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission. in Neurobiology of disease 2011
Show all 4 references for ABIN414578
Mouse (Murine) SNCA ELISA Kit for Sandwich ELISA - ABIN415770
Fanara, Wong, Husted, Liu, Liu, Kohlstaedt, Riiff, Protasio, Boban, Killion, Killian, Epling, Sinclair, Peterson, Price, Cabin, Nussbaum, Brühmann, Brandt, Christine, Aminoff, Hellerstein: Cerebrospinal fluid-based kinetic biomarkers of axonal transport in monitoring neurodegeneration. in The Journal of clinical investigation 2012
Show all 3 references for ABIN415770
study examined the spatial and temporal expression patterns of three synuclein genes (snca, sncbb, sncg (show SNCG ELISA Kits)) during embryogenesis
provides evidence for a novel interaction of alpha-synuclein and SOD1 (show SOD1 ELISA Kits) that might be relevant for neurodegenerative diseases
It found that chromosome 1 harbors an expression quantitative trait locus that modulates Sncg (show SNCG ELISA Kits) expression in the mouse retina, and identified the prefoldin-2 (PFDN2 (show PFDN2 ELISA Kits)) gene as the candidate upstream modulator of Sncg (show SNCG ELISA Kits) expression.
The response of CPLX1 (show CPLX1 ELISA Kits) and Foxp1 (show FOXP1 ELISA Kits) levels to SNCA deficiency supports the notion that these factors are regulated by altered physiological function of alpha-synuclein.
The pattern of expression and distribution of alpha-synuclein during the development of ciliary body and iris of mice, chick and fish data concluded that alpha-synuclein has important cellular function during eye development of studied animals.
Longitudinal Metabolomics Profiling of Parkinson's Disease-Related alpha-Synuclein A53T Transgenic Mice.
This would suggest that as complex I-deficient cells have already adapted to their mitochondrial defect, the subsequent toxic effects of alpha-synuclein are reduced.
The temporal expression pattern of alpha-synuclein modulates olfactory neurogenesis in transgenic mice and has an important role.
These findings support a reciprocal modulatory interaction of alpha-syn and synapsin III (show SYN3 ELISA Kits) in the regulation of dopamine neuron synaptic function.
Activation of MyD88 (show MYD88 ELISA Kits)-dependent TLR1 (show TLR1 ELISA Kits)/2 signaling by misfolded alpha-synuclein, a protein linked to neurodegenerative disorders.
The study reveals a function of SUMO protein modification as a Ubiquitin-independent ESCRT sorting signal, regulating the extracellular vesicle release of alpha-Synuclein.
Normal pattern of SNCA methylation during aging should not result in increased expression of alpha-synuclein protein.
In Parkinson's Disease, decreased salivary concentration of alpha-synuclein total may reflect the reduction of alpha-synuclein monomers, as well as the formation of insoluble intracellular inclusions and soluble oligomers.
Data suggest wild-type SNCA binding to synaptosome membrane is not affected by phosphorylation by PLK2 (polo like kinase 2 (show PLK2 ELISA Kits)); A30P SNCA, a Parkinson disease mutation, binding is greatly increased; endocytosis of SNCA fibrils follows similar pattern.
Human alpha-synuclein in null mice was transferred from one neuron to the other in the brain leading to initial neuronal injury.
In this study, we investigated the relationship between the rs3822086 C>T polymorphism located in the fourth intron of the alpha-synuclein (SNCA) gene and susceptibility to PD in a Chinese Han population.
analysis of PD-1 (show PDCD1 ELISA Kits) expression and cytokine secretion of Mycobacterium tuberculosis-specific CD4 (show CD4 ELISA Kits)+ T-cell subsets
The peripheral nervous system appears to be affected by Schwann cell alpha-syn deposits in the PLP (show PLP1 ELISA Kits)-alpha-syn multiple system atrophy mouse model.
Alleles "G" of rs356165 and rs356219 were associated with increased levels of SNCA expression and high alpha-synuclein levels rs356165 and rs356219 variants might influence on Parkinson's disease development by upregulating SNCA expression.
this is the first evidence for an association between RBCs-expressed alpha-Syn and pathogenic mechanisms involved in PD.
analysis of membrane curvature sensing by amphipathic helices using alpha-synuclein and annexin B12 (show TNFAIP1 ELISA Kits) [ANXB12]
Immunocytochemistry shows alpha synuclein localized to the Golgi apparatus and vesicles of bovine adrenal medullary chromaffin cells, consistent with its putative role in vesicular function within synapses.
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene.
, alpha SYN
, non-A beta component of AD amyloid
, non-A4 component of amyloid
, non A-beta component of AD amyloid
, synuclein alpha-140
, alpha synuclein