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TIPRL is an inhibitory regulator of protein phosphatase-2A (PP2A) (see PPP2CA\; MIM 176915), PP4 (see PPP4C\; MIM 602035), and PP6 (see PPP6C\; MIM 612725) (McConnell et al., 2007 [PubMed 17384681]).[supplied by OMIM, Nov 2010].. Additionally we are shipping TIP41, TOR Signaling Pathway Regulator-Like (S. Cerevisiae) Antibodies (51) and many more products for this protein.
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overexpression of TIPRL promotes phosphorylation of H2AX, and increases gamma-H2AX positive foci in response to DNA damage, whereas knockdown of TIPRL inhibits gamma-H2AX phosphorylation
Unlike yeast TIP41, TIPRL has a positive effect on mTORC1 signaling through the association with PP2Ac (show PPP2CA Proteins).
Data indicate that PP2A (show PPP2R4 Proteins) holoenzyme biogenesis and activity are controlled by five PP2A (show PPP2R4 Proteins) modulators, consisting of alpha4, PTPA (show PPP2R4 Proteins), LCMT1 (show LCMT1 Proteins), PME-1 (show PPME1 Proteins) and TIPRL1, which serve to prevent promiscuous phosphatase activity until the holoenzyme is completely assembled.
TIPRL is highly up-regulated in human HCC (show FAM126A Proteins) samples and cell lines, compared with noncancerous liver tissues.
TIPRL is an inhibitory regulator of protein phosphatase-2A (PP2A) (see PPP2CA\; MIM 176915), PP4 (see PPP4C\; MIM 602035), and PP6 (see PPP6C\; MIM 612725) (McConnell et al., 2007
, TIP41, TOR signalling pathway regulator-like
, putative MAPK activating protein
, putative MAPK-activating protein PM10
, type 2A-interacting protein