TYRO Protein tyrosine Kinase Binding Protein Proteins (TYROBP)

TYROBP encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. Additionally we are shipping TYROBP Antibodies (101) and TYROBP Kits (13) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat TYROBP TYROBP 361537 Q6X9T7
TYROBP 7305 O43914
Mouse TYROBP TYROBP 22177 O54885
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Top TYROBP Proteins at antibodies-online.com

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
$6,041.49
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details

TYROBP Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,

More Proteins for TYRO Protein tyrosine Kinase Binding Protein (TYROBP) Interaction Partners

Zebrafish TYRO Protein tyrosine Kinase Binding Protein (TYROBP) interaction partners

  1. The structure of the adaptor protein dap12 has been identified in the zebrafish genome.

  2. DAP12-based activating pathway is conserved between bony fish and mammals

Human TYRO Protein tyrosine Kinase Binding Protein (TYROBP) interaction partners

  1. Rare TYROBP variants might contribute to early-onset Alzheimer's disease risk by reduction of TREM2 (show TREM2 Proteins) expression, a well-established risk factor for AD.

  2. TYROBP influences a batch of genes that are related to Alzheimer's disease; ZNF329 and RB1 (show RB1 Proteins) significantly regulate those 'mesenchymal' gene expression signature genes for brain tumors. By merely leveraging gene expression data, Context Based Dependency Network (CBDN) can efficiently infer the existence of gene-gene interactions as well as their regulatory directions.

  3. TYROBP/CSTA gene interaction might play pivotal roles in the occurrence and development of Postmenopausal Osteoporosis

  4. The different expression of DAP12 compared to TREM2 (show TREM2 Proteins) represents the first description of such variable expressivity in Nasu-Hakola disease (NHD) microglia.

  5. the microglial membrane adaptor protein DAP12 was required for both nerve injury- and intrathecal CSF1 (show CSF1 Proteins)-induced upregulation of pain-related microglial genes and the ensuing pain, but not for microglial proliferation

  6. Impaired signaling by the TREM2 (show TREM2 Proteins)-DAP12 pathway leads to altered immune responses in phagocytosis, cytokine production, and microglial proliferation and survival, thus contributing to disease pathogenesis. Review.

  7. T cells modified to express a KIR (show GEM Proteins)-CAR and DAP12 exhibit superior antitumor activity compared with standard first- and second-generation CD3zeta (show CD247 Proteins)-based CARs in a xenograft model of mesothelioma highly resistant to immunotherapy.

  8. This study reveled that TYROBP having a central role in the bipolar disease and schizophrenia manifestation.

  9. isolated PMNs have an increased proportion of both TREM1 (show TREM1 Proteins) and DAP12 compared to normal healthy control

  10. results support a role of DAP12 in stabilizing TREM2 (show TREM2 Proteins)-CTF (show NFIA Proteins), thereby protecting against excessive pro-inflammatory responses.

Mouse (Murine) TYRO Protein tyrosine Kinase Binding Protein (TYROBP) interaction partners

  1. Recent studies have revealed that activated microglia in the spinal dorsal horn exacerbate neuropathic pain, which has suggested that suppression of microglial activity should be considered as a therapeutic target. However, only a few molecules have been identified as regulators of microglial activity. In this study, we focused on a receptor complex of TREM2 (show TREM2 Proteins) and DAP12, both of which are expressed by microglia and have bee

  2. TNF (show TNF Proteins)/IL-6 (show IL6 Proteins) generated osteoclasts in vitro that resorbed mineralized tissue through a pathway dependent on IL-6R, NFATc1 (show NFATC1 Proteins), DNAX-activation protein 12, and cell proliferation.

  3. The findings suggest that DAP12 acts as a brake on the pulmonary immune response to C. neoformans by promoting pulmonary eosinophilia and by inhibiting the activation and antifungal activities of effector cells, including NK cells and macrophages.

  4. significant role of DAP12 in the initial inflammatory response, bone remodeling and regeneration

  5. DAP12-mediated microglial activation following axotomy promotes pro-inflammatory responses, and thereby accelerates nerve injury-induced neuron death

  6. results support a role of DAP12 in stabilizing TREM2 (show TREM2 Proteins)-CTF (show NFIA Proteins), thereby protecting against excessive pro-inflammatory responses.

  7. a previously unrecognized role for DAP12 expression in tissue-resident alveolar macrophages in mediating acute noninfectious tissue injury through regulation of neutrophil trafficking.

  8. DAP12 expression in liver grafts regulates donor mDC (show ADAM11 Proteins) migration to host lymphoid tissue, alloreactive T cell responses and transplant tolerance

  9. Integrin alphav beta3/Dap12 double-deficient developed profound osteoporosis.

  10. Our study identifies the DAP12/IRAK-M (show IRAK3 Proteins)/IL-10 (show IL10 Proteins) to be a novel molecular pathway in APCs (show APCS Proteins) exploited by mycobacterial pathogens, allowing infection a foothold in the lung.

Cow (Bovine) TYRO Protein tyrosine Kinase Binding Protein (TYROBP) interaction partners

TYROBP Protein Profile

Protein Summary

This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene.

Gene names and symbols associated with TYROBP

  • TYRO protein tyrosine kinase binding protein (TYROBP)
  • TYRO protein tyrosine kinase binding protein (tyrobp)
  • Tyro protein tyrosine kinase binding protein (Tyrobp)
  • TYRO protein tyrosine kinase binding protein (Tyrobp)
  • dap12 protein
  • KARAP protein
  • Ly83 protein
  • PLOSL protein
  • TYROBP protein
  • tyrpbp protein

Protein level used designations for TYROBP

TYRO protein tyrosine kinase-binding protein , TYRO protein tyrosine kinase binding protein , DAP12 protein , dap12 , DAP12 , DNAX-activation protein 12 , killer cell activating receptor-associated protein , KAR-associated protein , killer activating receptor associated protein , killer-activating receptor-associated protein , killer cell activating receptor associated protein , immunoreceptor DAP12 , tyrosine kinase binding protein

GENE ID SPECIES
476477 Canis lupus familiaris
443208 Ovis aries
100101461 Danio rerio
361537 Rattus norvegicus
7305 Homo sapiens
22177 Mus musculus
282390 Bos taurus
397405 Sus scrofa
574207 Macaca mulatta
455968 Pan troglodytes
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