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Members of the ten-eleven translocation (TET) gene family, including TET3, play a role in the DNA methylation process (Langemeijer et al., 2009 [PubMed 19923888]).[supplied by OMIM, Nov 2010].. Additionally we are shipping and many more products for this protein.
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Mouse (Murine) Polyclonal TET3 Primary Antibody for WB - ABIN2668513
Otani, Kimura, Sharif, Endo, Mishima, Kawakami, Koseki, Shirakawa, Suetake, Tajima: Cell cycle-dependent turnover of 5-hydroxymethyl cytosine in mouse embryonic stem cells. in PLoS ONE 2013
Show all 2 Pubmed References
Mouse (Murine) Monoclonal TET3 Primary Antibody for ICC, IF - ABIN5563988
Bauer, Göbel, Nagaraj, Colantuoni, Wang, Müller, Kremmer, Rottach, Leonhardt: Phosphorylation of TET proteins is regulated via O-GlcNAcylation by the O-linked N-acetylglucosamine transferase (OGT). in The Journal of biological chemistry 2015
Human Polyclonal TET3 Primary Antibody for IHC, IHC (p) - ABIN4358587
Ni, Dansranjavin, Rogenhofer, Oeztuerk, Deuker, Bergmann, Schuppe, Wagenlehner, Weidner, Steger, Schagdarsurengin: TET enzymes are successively expressed during human spermatogenesis and their expression level is pivotal for male fertility. in Human reproduction (Oxford, England) 2016
Overexpression of the wild-type TET1 (show TET1 Antibodies)/2/3 3'UTR (show UTS2R Antibodies) caused a significant increase in EZH2 (show EZH2 Antibodies) expression and tumor growth, whereas the mutation in miR (show MLXIP Antibodies)-26-binding sites abolished this effect.
Because the DNA hypomethylation might be a result of TET dioxygenase activity, the study examined expression of TET1 (show TET1 Antibodies)-3 enzymes and the level of their product, 5-hydroxymethylcytosine (5hmC), in a panel of histologically characterized seminomas and non-seminomatous germ cell tumors. The study found highly increased expression of TET1 (show TET1 Antibodies) dioxygenase in most seminomas and strong TET1 (show TET1 Antibodies) staining in seminoma cells.
findings have identified distinct roles for TET2 (show TET2 Antibodies) and TET3 in human erythropoiesis, and provide new insights into their role in regulating human erythroid differentiation at distinct stages of development.
We found that TET1 (show TET1 Antibodies) and TET2 (show TET2 Antibodies) messenger RNA expression was lower and TET3 was higher in cancers compared to normal tissues. Positive correlation between 5-hmC and the relative expression of TET1 (show TET1 Antibodies) and TET2 (show TET2 Antibodies) was found, but no correlation was observed in the case of TET3.
TET1 (show TET1 Antibodies), TET2 (show TET2 Antibodies), and TET3 genes are downregulated in endometriosis.
Results revealed that TET3 acted as a suppressor of ovarian cancer by demethylating miR (show MLXIP Antibodies)-30d precursor gene promoter to block TGF-beta1 (show TGFB1 Antibodies)-induced epithelial-mesenchymal transition.
TET3 expression inhibits glioblastoma tumorigenesis and self-renewal in glioblastoma stem cells.
levels of TET3 and TDG (show TDG Antibodies) mRNAs were independent prognostic factors for early breast cancer patients who received anthracycline chemotherapy
Hypoxia deregulates TET3. TET1 (show TET1 Antibodies)/3 levels were associated with tumor hypoxia, tumor malignancy, and poor prognosis in breast cancer patients. Coordinate functions of TET1 (show TET1 Antibodies) and TET3 were needed to activate TNFalpha (show TNF Antibodies)-p38-MAPK (show MAPK14 Antibodies) signaling in hypoxia.
In hepatic stellate cells, cell proliferation rise significantly and cell apoptosis reduce obviously after knockdown of TET3.
TET3 negatively regulates type I IFN production.
Tet3, a DNA dioxygenase, can rapidly and efficiently convert fibroblasts directly into functional neurons.
Here the authors show that concomitant loss of Tet2 (show TET2 Antibodies) and Tet3 in mice at early B cell stage blocked the pro- to pre-B cell transition in the bone marrow, decreased Irf4 (show IRF4 Antibodies) expression and impaired the germline transcription and rearrangement of the Igkappa locus.
this study shows that simultaneous deletion of Tet2 (show TET2 Antibodies) and Tet3 in mouse CD4 (show CD4 Antibodies)+CD8 (show CD8A Antibodies)+ double-positive thymocytes results in dysregulated development and proliferation of invariant natural killer T cells
The CXXC domain of Tet3 has the capacity to bind to unmethylated and carboxylated cytosines at CpG sequences and a very restricted genomic localization pattern with a preference for transcription start sites.
Genetic ablation of TET3 in oocytes had no significant effect on oocyte development.
the stability of Foxp3 (show FOXP3 Antibodies) expression is markedly compromised in T reg (show KCNH2 Antibodies) cells from Tet2 (show TET2 Antibodies)/Tet3 double-deficient mice.
The DNA demethylation marks are dynamically regulated in both in vivo and in vitro aging conditions, which are associated with Tet3 over-expression and Tdg (show TDG Antibodies) repression.
Knockdown of Tet1 (show TET1 Antibodies) and Tet3 by RNAi in ex vivo cerebellar slice cultures inhibits dendritic arborization of developing cerebellar granule cells, a critical step in circuit formation
This paper demonstrates a Tet3-dependent mechanism underlying the dexamethasone-induced epigenetic reprogramming leading to heritable alterations of a fundamental player in cortical development.
Members of the ten-eleven translocation (TET) gene family, including TET3, play a role in the DNA methylation process (Langemeijer et al., 2009
probable methylcytosine dioxygenase TET3
, tet oncogene family member 3
, methylcytosine dioxygenase TET3