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TPMT encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Additionally we are shipping TPMT Proteins (31) and TPMT Kits (15) and many more products for this protein.
Showing 10 out of 105 products:
Human Monoclonal TPMT Primary Antibody for IF, IHC (p) - ABIN563239
Egle, Milek, Mlinaric-Rascan, Fahr, Kristl: A novel gene delivery system for stable transfection of thiopurine-S-methyltransferase gene in versatile cell types. in European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2008
Show all 2 Pubmed References
Human Monoclonal TPMT Primary Antibody for ELISA, WB - ABIN563241
Hayashi, Naoi, Nakagawa, Nishikawa, Fukuda, Imajoh-Ohmi, Kondo, Kubo, Yabuki, Hattori, Hirouchi, Sugiyama: Sorting nexin 27 interacts with multidrug resistance-associated protein 4 (MRP4) and mediates internalization of MRP4. in The Journal of biological chemistry 2012
With the significant mitigation of TPMT wild type-expressing cells to cisplatin cytotoxicity, findings demonstrate a drug-gene interaction between increased TPMT activity and decreased susceptibility to cisplatin-induced toxicity of inner ear cells.
These findings support the notion that germline polymorphisms in Tpmt affect not only host tissue toxicity but also antitumor effectiveness.
suggestion that differential mouse TPMT activity is due to variation in mRNA expression
TPMT*3C is overrepresented in acute lymphoblastic leukemia (ALL) cases in comparison with non-ALL group
The frequency of TPMT mutation in a homogeneous Sicilian cohort of patients with inflammatory bowel disease, autoimmune and hematological disorders was low. TPMT genotyping is not a sensitive tool for predicting thiopurine-induced leukopenia.
meta-analysis of three independent GWAS of TPMT activity; only genetic variants mapping to chromosome 6, including the TPMT gene region, were significantly associated with TPMT activity;finding is consistent with TPMT genotype being the primary determinant of TPMT activity
In a GWAS, TPMT activity in patients behaves as a monogenic trait, further bolstering the utility of TPMT genetic testing in the clinic
Review/Meta-analysis: thiopurine S-methyltransferase testing for averting drug toxicity.
A point mutation in the thiopurine S-methyltransferase gene that led to exon 5 deletion in the transcribed mRNA.
The aims of this research were to investigate the association of TPMT phenotypes with MDR1 (show TBC1D9 Antibodies) genotypes.
The aim of the study was to investigate frequencies of TPMT and ITPA (show ITPA Antibodies) polymorphisms in Lithuanian inflammatory bowel disease patients and analyze their association with azathioprine-related adverse events.
With respect to TPMT, the variants TPMT*2 and TPMT*3A were not implicated in genetic susceptibility to childhood acute lymphoblastic leukemia
structure-function relationships of TPMT
This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals. A pseudogene for this locus is located on chromosome 18q.
, Thiopurine S-methyltransferase
, S-adenosyl-L-methionine:thiopurine S-methyltransferase
, thiopurine methyltransferase
, NHL repeat containing 1