TPMT antibody

Catalog No. ABIN7270797

The Rabbit Monoclonal anti-TPMT antibody (ABIN7270797) specifically detects TPMT in WB. The antibody is reactive with Human samples.

Quick Overview for TPMT antibody (ABIN7270797)

Target: TPMT (Thiopurine S-Methyltransferase (TPMT))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This TPMT antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TPMT Antibody

Purpose: TPMT Rabbit mAb

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Monoclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant protein of Human TPMT.

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for TPMT

Target: TPMT (Thiopurine S-Methyltransferase (TPMT))

Alternative Name: TPMT

Background: This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X.,TPMT,TPMTD,Signal Transduction,Endocrine & Metabolism,Drug metabolism,TPMT

Molecular Weight: 28kDa

Gene ID: 7172

UniProt: P51580