anti-Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8) Antibodies

Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Additionally we are shipping TRPM8 Proteins (9) and TRPM8 Kits (2) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
TRPM8 79054 Q7Z2W7
TRPM8 171382 Q8R4D5
TRPM8 171384 Q8R455
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Top anti-TRPM8 Antibodies at antibodies-online.com

Showing 10 out of 159 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB <b>WB Suggested Anti-TRPM8 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:312500<br><b>Positive Control: </b>ACHN cell lysate Immunohistochemistry with Prostate tissue at an antibody concentration of 5µg/ml using anti-TRPM8 antibody (ARP35357_P050) 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB Host: Rabbit Target Name: TRPM8 Sample Type: 293T Whole Cell lysates Antibody Dilution: 1.0ug/ml 100 μL Log in to see 2 to 3 Days
$289.00
Details
Fruit Fly Rabbit Un-conjugated ICC, IHC (fro), IF, IHC (p), IHC, ELISA, WB Detection of Trp-p8 in transfected Cos cell lysate using ABIN152287 (1:750). Prostate cancer: Formalin-Fixed Paraffin-Embedded (FFPE) 0.1 mg Log in to see 7 to 9 Days
$500.06
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of TRPM8 expression in A549 (A), PC3 (B), NIH3T3 (C), H9C2 (D) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB TRPM8 Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human prostate carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of TRPM8 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated. TRPM8 Antibody (N-term) western blot analysis in NCI-H460 cell line lysates (35 µg/lane). This demonstrates the TRPM8 antibody detected the TRPM8 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IF, IHC (p), WB TRPM8 Antibody (Center) (ABIN655714) immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Bat Rabbit Un-conjugated IHC (p) Anti-TRPM8 antibody  ABIN1049435 IHC staining of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Log in to see 7 to 9 Days
$451.00
Details
Guinea Pig Rabbit Un-conjugated IHC (p) Anti-TRPM8 antibody  ABIN1049436 IHC staining of human prostate carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Log in to see 7 to 9 Days
$451.00
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB   0.1 mg Log in to see 12 to 15 Days
$357.50
Details

TRPM8 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-TRPM8 Antibodies

  1. Fruit Fly (Drosophila melanogaster) Polyclonal TRPM8 Primary Antibody for ICC, IHC (fro) - ABIN152287 : Peabody, Pohl, Diao, Vreede, Sandstrom, Wang, Zelensky, White: Characterization of the decision network for wing expansion in Drosophila using targeted expression of the TRPM8 channel. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2009 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal TRPM8 Primary Antibody for ELISA - ABIN451742 : Dhaka, Murray, Mathur, Earley, Petrus, Patapoutian: TRPM8 is required for cold sensation in mice. in Neuron 2007 (PubMed)

  3. Human Polyclonal TRPM8 Primary Antibody for ICC, IF - ABIN4362970 : Wang, Yu, Yan, Lei, Chai, Jiang, Yuan, Xing, Du: TRPM8 in the negative regulation of TNFα expression during cold stress. in Scientific reports 2017 (PubMed)

More Antibodies against TRPM8 Interaction Partners

Guinea Pig Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8) interaction partners

  1. The role of TRPM8 in the Guinea-pig bladder-cooling reflex investigated using a novel TRPM8 antagonist

Human Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8) interaction partners

  1. our results indicate that enhanced TRPM8 hydrolysis in prostate cancer could present an adaptation mechanism, sustained via bypassing testosterone-induced rapid Ca2 (show CA2 Antibodies)+ uptake through TRPM8, thus, diminishing the rates of apoptosis

  2. Suggest a novel, pore-independent molecular mechanism by which endogenous TRPM8 expression inhibits Rap1 (show RABGEF1 Antibodies) GTPase (show RACGAP1 Antibodies) and thus plays a critical role in the behavior of vascular endothelial cells by inhibiting migration.

  3. in this study, the glycosylation status of the TRPM8 channel was shown to affect cell proliferation, cell migration, and calcium uptake. TRPM8 expressed in the membrane of the Panc-1 pancreatic tumoral cell line is non-glycosylated, whereas human embryonic kidney cells transfected with human TRPM8 overexpress a glycosylated protein.

  4. This study demonstrates that TRPM8 (cold receptor) is present in nasal epithelium. When it is activated by moderate cooling at 24 degrees C or menthol, TRPM8 induces the secretion of mucin (show SLC13A2 Antibodies). This study determines that TRPM8 channels are important regulators of mucin (show SLC13A2 Antibodies) production. Therefore, TRPM8 antagonists could be used for the treatment of refractory rhinitis.

  5. This study suggests that the TRPM8 sensor is a key determinant of germ cell fate under hypothermic stimulation.

  6. TRPM8 SNPs are significantly associated with the risk of COPD in the Chinese Han population.

  7. TRPM8 activation is likely to occur when cigarettes contain more than 50 micrograms of menthol.

  8. This review outlines our current understanding on the role of TRPM8 in occurrence and development of different kinds of tumor and also includes discussion about the regulation of TRPM8 during carcinogenesis as well as therapeutic potential of targeting TRPM8 in tumor, which may be utilized for a potential pharmacological use as a target for anti-cancer therapy.[review]

  9. The effects of specific agents on TRPV1 (show TRPV1 Antibodies) and TRPM8 channels are intricately interrelated.

  10. The data of this study provided evidence for decreased activity and expression level of TRPM8 in the presence of methylglyoxal.

Mouse (Murine) Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8) interaction partners

  1. TRPM8 in macrophages determines pro- or anti-inflammatory actions by regulating tumor necrosis factor-alpha (show TNF Antibodies) and interleukin-10 (show IL10 Antibodies) production. These findings suggest novel TRPM8-based options for immunomodulatory intervention.

  2. Here the authors show that AITC (allyl isothiocyanate; mustard oil) and menthol represent two distinct types of ligands at the mammalian cold sensor TRPM8.

  3. The results of this study show that chronic morphine upregulates TRPM8 channels, which is in contrast with the previous finding that acute morphine triggers TRPM8 internalization.

  4. data suggest that sex differences in the functioning of Ih and Ik in TRPM8 expressing primary afferent neurons leads to differences in cool temperature sensitivity

  5. This study suggests that the TRPM8 sensor is a key determinant of germ cell fate under hypothermic stimulation.

  6. We identify PLCdelta4 as a PLC (show HSPG2 Antibodies) isoform important in the regulation of TRPM8 both at the cellular level and in vivo

  7. Reduced functional expression of TRPM8 in sensory neurons (due to VAMP7 (show VAMP7 Antibodies) knockout) is associated with deficits in cold avoidance and icilin-induced cold hypersensitivity.

  8. Report essential role of skin TRPM8 in a model of acute cold-induced urinary urgency.

  9. This study findings suggest the existence of VGLUT2 (show SLC17A6 Antibodies) (but not VGLUT1 (show SLC17A7 Antibodies))-mediated glutamate (show GRIN1 Antibodies) signaling in TRPM8+ neurons possibly underlying the cold-induced acute pain and hypersensitivity to cold following pulpal inflammation.

  10. Data suggest that blockage of transient receptor potential (TRP) channels TRPA1 (show TRPA1 Antibodies), TRPV4 (show TRPV4 Antibodies) and possibly TRPM8 may represent a therapeutic option for patients with colonic discomfort and pain.

TRPM8 Antigen Profile

Protein Summary

Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing.

Gene names and symbols associated with TRPM8

  • transient receptor potential cation channel, subfamily M, member 8 (TRPM8) antibody
  • transient receptor potential cation channel, subfamily M, member 8 (trpm8-b) antibody
  • transient receptor potential cation channel, subfamily M, member 8 (Trpm8) antibody
  • CMR1 antibody
  • LTrpC-6 antibody
  • LTRPC6 antibody
  • Trp-p8 antibody
  • TRPM8 antibody
  • trpm8b antibody
  • TRPP8 antibody

Protein level used designations for TRPM8

transient receptor potential cation channel, subfamily M, member 8 , transient receptor potential cation channel subfamily M member 8b , transient receptor potential cation channel subfamily M member 8 , transient potential cation channel subfamily M member 8 , LTrpC-6 , long transient receptor potential channel 6 , short form of the TRPM8 cationic channel , transient receptor potential p8 , transient receptor potential subfamily M member 8 , trp-p8 , TRP ion channel TRPM8 , transient receptor potential-p8 , cold menthol receptor 1 , cold/menthol receptor 1 , menthol receptor , transient receptor potential M8 protein , transient receptor potential cation channel, subfamily M, member 8 (predicted), 3 prime , transient receptor potential cation channel, subfamily M, member 8 (predicted), 5 prime

GENE ID SPECIES
100137386 Papio anubis
100302012 Xenopus laevis
100337634 Cavia porcellus
79054 Homo sapiens
171382 Mus musculus
171384 Rattus norvegicus
424025 Gallus gallus
486170 Canis lupus familiaris
541151 Bos taurus
100328692 Oryctolagus cuniculus
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