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TMPRSS4 encodes a member of the serine protease family. Additionally we are shipping TMPRSS4 Antibodies (78) and TMPRSS4 Kits (7) and many more products for this protein.
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in vivo TMPRSS4a gene silencing caused severe defects in tissue development and cell differentiation including a disturbed skeletal muscle formation, a decelerated heartbeat, and a degenerated vascular system
The increase of TMPRSS4 expression may be a key event for HCC (show FAM126A Proteins) progression and may be regarded as a potential prognostic marker for HCC (show FAM126A Proteins).
suggesting that TMPRSS4 is associated with a cancer stem cells phenotype in patients' tumors
TMPRSS4 expression is associated with postoperative recurrence. In addition, the current survival curves demonstrated that TMPRSS4 expression is associated with statistically significant differences in survival among patients with lung adenocarcinoma.
In prostate cancer, high TMPRSS4 expression was significantly associated with advanced tumor stage and lymphatic metastasis.
TMPRSS4 is overexpressed in thyroid cancer and TMPRSS4-CREB (show CREB1 Proteins) signaling is needed to sustain thyroid cancer cell proliferation.
TMPRSS4 is upregulated by silencing of TFPI-2 (show TFPI2 Proteins) through aberrant DNA methylation (show HELLS Proteins) and contributes to oncogenesis in non-small cell lung cancer.
On the basis of this information and the structural characteristics of this druggable protease, we suggest that TMPRSS4 could be a novel potential therapeutic target in solid tumours.
TMPRSS4 was associated with CRC (show CALR Proteins) stage and regulated the proliferation and self-renewal ability of colon cancer cells; TMRPSS4 was involved in the development and progression of CRC (show CALR Proteins).
TMPRSS4 was an independent predictor of OS and DFS (show FST Proteins).
High expression of TMPRSS4 was significantly associated with advanced TNM (show ODZ1 Proteins) stage.
Epithelial Sodium Channel-Mediated Sodium Transport Is Not Dependent on the Membrane-Bound Serine Protease (show F2 Proteins) CAP2/Tmprss4
Progression and metastatic potential of several cancers is concordant with an increased expression of TMPRSS4.
TMPRSS4 primarily activates ENaC (show SCNN1A Proteins) by cleaving basic residues within the tract gammaK173-K186 distal to the furin (show FURIN Proteins) cleavage site, thereby releasing a previously defined key inhibitory tract encompassing gammaR158-F168 from the gamma-subunit.
mutations in conserved residues of mCAP2 located in two protein-protein interacting domains significantly modulated ENaC (show SCNN1A Proteins) activation
This gene encodes a member of the serine protease family. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified as a gene overexpressed in pancreatic carcinoma. The encoded protein is membrane bound with a N-terminal anchor sequence and a glycosylated extracellular region containing the serine protease domain. Multiple transcript variants encoding different isoforms have been found for this gene.
transmembrane protease, serine 4
, channel-activating protease 2
, membrane-type serine protease 2
, transmembrane protease serine 4
, transmembrane serine protease 3
, type II membrane serine protease