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TREM1 encodes a receptor belonging to the Ig superfamily that is expressed on myeloid cells. Additionally we are shipping TREM1 Antibodies (280) and TREM1 Kits (69) and many more products for this protein.
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Human TREM1 Protein expressed in Wheat germ - ABIN1323572
Li, Birkenheuer, Marr, Levy, Yoder, Nordone: Expression and function of triggering receptor expressed on myeloid cells-1 (TREM-1) on canine neutrophils. in Developmental and comparative immunology 2011
Show all 2 Pubmed References
The results demonstrate that both commensal and pathogenic oral bacteria activate the TREM-1 pathway, resulting in a proinflammatory TREM-1 activity-dependent increase in proinflammatory cytokine production.
Our findings suggest a novel modulatory role of TREM-1 in the pathogenesis of SLE. sTREM-1 production is a useful diagnostic marker and a molecular target for combination therapy of lupus.
In the premature rupture of membranes group,the NF-kappaB (show NFKB1 Proteins) p65 (show GORASP1 Proteins) and sTREM-1 levels in maternal blood were significantly higher in women with chorioamnionitis than women without chorioamnionitis (P<.05).
Diagnostic value of sTREM-1, IL-8 (show IL8 Proteins), PCT (show UROD Proteins), and CRP (show CRP Proteins) in febrile neutropenia after autologous stem cell transplantation
findings showed detectable expression of TREM-1 in 100% of samples, urinary tract infection (UTI (show AMBP Proteins)) and non-UTI (show AMBP Proteins) groups; levels of sTREM-1 were detected in patients with UTI (show AMBP Proteins), but not in non-UTI (show AMBP Proteins) patients; TREM-1 levels in patients with UTI (show AMBP Proteins) tend to be higher and are associated with increased neutrophils and cytokine activity induced by bacteria
This study provided evidence that rs6910730G, an intronic variant of TREM1, reduced the ability of human monocytes for Abeta (show APP Proteins) phagocytosis, and this reduction was likely attributed to a decreased monocytic TREM1 expression.
Studies show that bronchoalveolar lavage fluid (BALF) soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) levels do not discriminate between mild-to-moderate asthma and chronic obstructive pulmonary disease (COPD (show ARCN1 Proteins)), in contrast, the interleukin 6 (IL-6 (show IL6 Proteins))/interleukine 13 (IL-13 (show IL13 Proteins)) ratio measured in BALF effectively differentiated these two diseases.
study found that soluble TREM-1 is increased and correlates with the clinical and laboratory findings in Crimean Congo Haemorrhagic Fever, a viral infection characterized by activation of inflammation.
The findings suggest that there are no differences in soluble TREM-1 levels in gingival crevicular fluid between healthy and periodontally diseased elderly adults
TREM-1 was found to be significantly higher in tissues biopsies and blood of subjects with obesity. Greater expression and activity of TREM-1 suggest a possible role in the underlying pathophysiology of obesity and associated comorbidities.
these data suggested that TREM-1 signaling pathway may be a therapeutic target to prevent the effects of the inflammatory dendritic cells in systemic lupus erythematosus and miRNA-150 serves as the important regulator
The immune receptor Trem1 cooperates with diminished DNA damage response to induce preleukemic stem cell expansion
This study is the first to show the regulatory role of TREM-1 in RLRs and TLRs expression.
TREM-1 is upregulated in renal inflammation and plays a vital role in driving disease. Thus, TREM-1 blockade emerges as a potential therapeutic avenue for immune-mediated renal diseases such as lupus nephritis
TGF-beta1 (show TGFB1 Proteins) increased the expression of TREM-1 in mouse macrophages partly via the transcription factor AP-1 (show JUN Proteins).
in macrophages, oxidized low-density lipoprotein enhanced expression of TREM-1, which amplifies the innate immune response of Toll (show TLR4 Proteins)-like receptor pathway; activation of TREM-1 contributes to atherogenesis process by enhancing proinflammatory cytokine production and foam cell formation.
TREM-1 and Dectin-1 (show CLEC7A Proteins) function concurrently in the corneal innate immune response by regulating inflammatory cytokine expression in fungal keratitis.
a novel positive feedback cycle mediated by TREM-1 and GM-CSF (show CSF2 Proteins) was revealed to enhance macrophage polarization under unilateral ureteral obstruction.
TREM-1-mediated innate immune response played an essential role in the activation of neutrophils and Streptococcus suis clearance.
Molecular cloning of bovine TREM-1 extends the repertoire of bovine pattern recognition receptors and provides information important for investigating their role in bovine innate immunity.
This gene encodes a receptor belonging to the Ig superfamily that is expressed on myeloid cells. This protein amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
triggering receptor expressed on myeloid cells 1
, triggering receptor expressed on monocytes 1
, triggering-receptor TREM1
, triggering receptor expressed in monocytes 1
, triggering receptor expressed on myeloid cells-1