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TREML2 is located in a gene cluster on chromosome 6 with the single Ig variable (IgV) domain activating receptors TREM1 (MIM 605085) and TREM2 (MIM 605086), but it has distinct structural and functional properties (Allcock et al., 2003 [PubMed 12645956]).[supplied by OMIM, Mar 2008].. Additionally we are shipping TREML2 Antibodies (43) and TREML2 Kits (12) and many more products for this protein.
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Human TREML2 Protein expressed in Human Cells - ABIN2004481
Mungall, Palmer, Sims, Edwards, Ashurst, Wilming, Jones, Horton, Hunt, Scott, Gilbert, Clamp, Bethel, Milne, Ainscough, Almeida, Ambrose, Andrews, Ashwell, Babbage, Bagguley, Bailey, Banerjee, Barker et al.: The DNA sequence and analysis of human chromosome 6. ... in Nature 2003
Show all 4 references for ABIN2004481
Missense variant in TREML2 protects against Alzheimer's disease.
TLT2 may be involved in the innate immune response based on its expression profile and the fact that it is up-regulated in response to inflammation.
analysis of an interaction between B7-H3 (show CD276 Proteins) and TLT-2 that preferentially enhances CD8 (show CD8A Proteins)(+) T cell activation
Data do not point to a role for TREML2 as a receptor for B7-H3 (show CD276 Proteins).
Thus, our studies identified TLT2 as an engulfment receptor for apoptotic cells.
TLT2 ligation enhances the neutrophil response to the formylated peptide FMLF, leading to increased reactive oxygen species production, degranulation, and chemotaxis
(+) T-cell effector function, possibly by ligation of TLT-2 on tumour-infiltrating CD8 (show CD8A Proteins)(+) T cells at the local tumour site.
TREML2 is located in a gene cluster on chromosome 6 with the single Ig variable (IgV) domain activating receptors TREM1 (MIM 605085) and TREM2 (MIM 605086), but it has distinct structural and functional properties (Allcock et al., 2003
triggering receptor expressed on myeloid cells-like 2
, triggering receptor expressed on myeloid cells
, trem-like transcript 2 protein
, triggering receptor expressed on myeloid cells-like protein 2
, triggering receptor expressed on myeloid cells-like 2a dominant