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Tripartite Motif Containing 21 Proteins (TRIM21)

TRIM21 encodes a member of the tripartite motif (TRIM) family. Additionally we are shipping TRIM21 Antibodies (88) and TRIM21 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TRIM21 6737 P19474
TRIM21 20821  
Rat TRIM21 TRIM21 308901  
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Top TRIM21 Proteins at antibodies-online.com

Showing 10 out of 17 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His-SUMO Tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
Yeast Human His tag 50 μg Log in to see 31 to 36 Days
$341.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$3,322.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   10 μg Log in to see 6 to 11 Days
$142.86
Details
HOST_Sf-9 cells Human Un-conjugated   1 mg Log in to see 3 to 4 Days
$4,009.50
Details
HOST_Cow Cow Un-conjugated   0.2 mg Log in to see 6 to 11 Days
$1,085.71
Details
HOST_Cow Cow Un-conjugated   1000 units Log in to see 6 to 11 Days
$1,742.86
Details

TRIM21 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
,
Mouse (Murine)
,

More Proteins for Tripartite Motif Containing 21 (TRIM21) Interaction Partners

Human Tripartite Motif Containing 21 (TRIM21) interaction partners

  1. The interaction of TRIM21 and LFG (show FAIM2 Proteins) was analyzed by co-immunoprecipitation. To examine changes in regulatory processes, western blot analyses, real-time PCR, activity of apoptotic process and flow cytometric analyses were carried out.

  2. TRIM21 plays an essential role in p62-regulated redox homeostasis and may be a viable target for treating pathological conditions resulting from oxidative damage.

  3. TRIM21-induced exposure of the viral genome promotes sensing of DNA and RNA viruses by cGAS and RIG-I (show DDX58 Proteins)

  4. we prove that TRIM21 is a potential tumor suppressor in hepatocellular carcinoma and its low expression indicates poor prognosis

  5. Trim21 regulates Nmi (show MYO1C Proteins)-IFI35 (show IFI35 Proteins) complex-mediated inhibition of innate antiviral response

  6. TRIM20 (show MEFV Proteins) and TRIM21 mediate precision autophagy, controlling the hub signaling machineries and key factors, inflammasome and type I interferon (show IFNA Proteins), directing cardinal (show CARD8 Proteins) innate immunity response systems in humans.

  7. This study elucidates a complex mechanism of step-wise ubiquitination and deubiquitination activities that allows contemporaneous innate immune signaling and neutralization by TRIM21.

  8. Anti-Ro52/TRIM21 antibodies are independently associated with the presence of interstitial lung disease and poor survival in systemic sclerosis.

  9. Endoplasmic reticulum stress causes autophagy and apoptosis leading to cellular redistribution of the SS-A and SS-B autoantigens in salivary gland epithelial cells of Sjogren's syndrome patients.

  10. These data extend the protective role of TRIM21 from viruses to bacteria and thereby strengthening the general role of antibody-dependent intracellular neutralisation in cellular immunity.

Cow (Bovine) Tripartite Motif Containing 21 (TRIM21) interaction partners

Mouse (Murine) Tripartite Motif Containing 21 (TRIM21) interaction partners

  1. Antibody affinity modulates TRIM21 immune function. TRIM21 mediates neutralization under suboptimal conditions, whereas induction of immune signaling is balanced according to the functional affinity for the incoming immune stimuli.

  2. TRIM21 plays an essential role in p62-regulated redox homeostasis and may be a viable target for treating pathological conditions resulting from oxidative damage.

  3. Trim21, an estrogen receptor (show ESR1 Proteins) coactivator, induces MYC (show MYC Proteins) oncogene (show RAB1A Proteins) by removing repressive CoAA (show RBM14 Proteins) through E2-dependent degradation of CoAA (show RBM14 Proteins).

  4. results demonstrate that TRIM21 provides potent antiviral protection and forms an important part of the humoral immune response

  5. Simultaneous neutralization and innate immune detection of replicating mouse adenovirus type 1 by TRIM21.

  6. Intracellular antibody-bound pathogens stimulate immune signaling via the Fc receptor (show FCGRT Proteins) TRIM21.

  7. TRIM21 is an interferon (show IFNA Proteins)-inducible E3 ligase that induces the Lys48-linked ubiquitination and degradation of DDX41 (show DDX41 Proteins) and negatively regulates the innate immune response to intracellular double-stranded DNA.

  8. analysis of a novel role for tyrosine phosphorylation in regulating the interaction with IRF3 (show IRF3 Proteins) and the activity of TRIM21 downstream of TLR3 (show TLR3 Proteins) and TLR4 (show TLR4 Proteins)

  9. Ro52 is an E3 ligase for interferon (show IFNA Proteins) regulatory factor (IRF)-8 (show IRF8 Proteins) that acts in a non-degradation pathway of ubiquitination and contributes to the elicitation of innate immunity in macrophages.

  10. TRIM21 is a previously undescribed type of IgG receptor based on a non-Ig scaffold whose interaction at the fundamental level-structural, thermodynamic, and kinetic-is evolutionarily conserved.

TRIM21 Protein Profile

Protein Summary

This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined.

Gene names and symbols associated with TRIM21

  • tripartite motif containing 21 (TRIM21)
  • tripartite motif-containing 21 (TRIM21)
  • tripartite motif-containing 21 (Trim21)
  • RNF81 protein
  • Ro52 protein
  • SSA protein
  • Ssa1 protein

Protein level used designations for TRIM21

tripartite motif-containing 21 , 52 kDa Ro protein-like , tripartite motif containing 21 , 52 kDa Ro protein , 52 kDa ribonucleoprotein autoantigen Ro/SS-A , E3 ubiquitin-protein ligase TRIM21 , RING finger protein 81 , SS-A , Sicca syndrome antigen A , Sjogren syndrome antigen A1 (52kDa, ribonucleoprotein autoantigen SS-A/Ro) , ro(SS-A) , sjoegren syndrome type A antigen , tripartite motif-containing protein 21 , 52kD Ro/SSA autoantigen , Sjogren syndrome antigen A1 , tripartite motif protein 21

GENE ID SPECIES
717826 Macaca mulatta
100387049 Callithrix jacchus
100454593 Pongo abelii
100601201 Nomascus leucogenys
6737 Homo sapiens
100302538 Sus scrofa
359715 Bos taurus
485226 Canis lupus familiaris
20821 Mus musculus
308901 Rattus norvegicus
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