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TRIM21 encodes a member of the tripartite motif (TRIM) family. Additionally we are shipping TRIM21 Proteins (23) and TRIM21 Kits (4) and many more products for this protein.
Showing 10 out of 93 products:
Dog (Canine) Polyclonal TRIM21 Primary Antibody for WB - ABIN2778305
Yamochi, Ohnuma, Hosono, Tanaka, Kanai, Morimoto: SSA/Ro52 autoantigen interacts with Dcp2 to enhance its decapping activity. in Biochemical and biophysical research communications 2008
Human Polyclonal TRIM21 Primary Antibody for EIA, IHC (p) - ABIN569661
Chan, Di Donato, Hamel, Tseng, Buyon: 52-kD SS-A/Ro: genomic structure and identification of an alternatively spliced transcript encoding a novel leucine zipper-minus autoantigen expressed in fetal and adult heart. in The Journal of experimental medicine 1995
TRIM21 role in TRAIL-induced apoptosis
Our data suggest that patients with IIM, mainly DM, are characterized by a deficient expression of Ro52/TRIM21 in different PBMC subsets (CD4 (show CD4 Antibodies)(+) lymphocytes and monocytes), along with lower K48-mediated ubiquitination, which is associated with a proinflammatory cytokine response.
Significant relationships were found between clinical and laboratory manifestations of autoimmune and rheumatic diseases with different patterns of antibodies to anti-Ro52, anti-Ro60 (show TROVE2 Antibodies) and anti-La .
downregulation of miR (show MLXIP Antibodies)-1207-5p and miR (show MLXIP Antibodies)-4695-3p expression may lead to increased TRIM21 levels in the minor salivary glands, which contributes to the development of Sjogren's syndrome
The interaction of TRIM21 and LFG (show FAIM2 Antibodies) was analyzed by co-immunoprecipitation. To examine changes in regulatory processes, western blot analyses, real-time PCR, activity of apoptotic process and flow cytometric analyses were carried out.
TRIM21 plays an essential role in p62-regulated redox homeostasis and may be a viable target for treating pathological conditions resulting from oxidative damage.
TRIM21-induced exposure of the viral genome promotes sensing of DNA and RNA viruses by cGAS and RIG-I (show DDX58 Antibodies)
we prove that TRIM21 is a potential tumor suppressor in hepatocellular carcinoma and its low expression indicates poor prognosis
Trim21 regulates Nmi (show MYO1C Antibodies)-IFI35 (show IFI35 Antibodies) complex-mediated inhibition of innate antiviral response
TRIM20 (show MEFV Antibodies) and TRIM21 mediate precision autophagy, controlling the hub signaling machineries and key factors, inflammasome and type I interferon (show IFNA Antibodies), directing cardinal (show CARD8 Antibodies) innate immunity response systems in humans.
Antibody affinity modulates TRIM21 immune function. TRIM21 mediates neutralization under suboptimal conditions, whereas induction of immune signaling is balanced according to the functional affinity for the incoming immune stimuli.
Trim21, an estrogen receptor (show ESR1 Antibodies) coactivator, induces MYC (show MYC Antibodies) oncogene (show RAB1A Antibodies) by removing repressive CoAA (show RBM14 Antibodies) through E2-dependent degradation of CoAA (show RBM14 Antibodies).
results demonstrate that TRIM21 provides potent antiviral protection and forms an important part of the humoral immune response
Simultaneous neutralization and innate immune detection of replicating mouse adenovirus type 1 by TRIM21.
Intracellular antibody-bound pathogens stimulate immune signaling via the Fc receptor (show FCGRT Antibodies) TRIM21.
TRIM21 is an interferon (show IFNA Antibodies)-inducible E3 ligase that induces the Lys48-linked ubiquitination and degradation of DDX41 (show DDX41 Antibodies) and negatively regulates the innate immune response to intracellular double-stranded DNA.
analysis of a novel role for tyrosine phosphorylation in regulating the interaction with IRF3 (show IRF3 Antibodies) and the activity of TRIM21 downstream of TLR3 (show TLR3 Antibodies) and TLR4 (show TLR4 Antibodies)
Ro52 is an E3 ligase for interferon (show IFNA Antibodies) regulatory factor (IRF)-8 (show IRF8 Antibodies) that acts in a non-degradation pathway of ubiquitination and contributes to the elicitation of innate immunity in macrophages.
TRIM21 is a previously undescribed type of IgG receptor based on a non-Ig scaffold whose interaction at the fundamental level-structural, thermodynamic, and kinetic-is evolutionarily conserved.
This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined.
tripartite motif-containing 21
, 52 kDa Ro protein-like
, tripartite motif containing 21
, 52 kDa Ro protein
, 52 kDa ribonucleoprotein autoantigen Ro/SS-A
, E3 ubiquitin-protein ligase TRIM21
, RING finger protein 81
, Sicca syndrome antigen A
, Sjogren syndrome antigen A1 (52kDa, ribonucleoprotein autoantigen SS-A/Ro)
, sjoegren syndrome type A antigen
, tripartite motif-containing protein 21
, 52kD Ro/SSA autoantigen
, Sjogren syndrome antigen A1
, tripartite motif protein 21