Tumor Necrosis Factor, alpha-Induced Protein 8-Like 2 Proteins (TNFAIP8L2)

Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Additionally we are shipping Tumor Necrosis Factor, alpha-Induced Protein 8-Like 2 Antibodies (55) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TNFAIP8L2 79626 Q6P589
TNFAIP8L2 69769 Q9D8Y7
Rat TNFAIP8L2 TNFAIP8L2 310663 Q6AYJ8
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Top Tumor Necrosis Factor, alpha-Induced Protein 8-Like 2 Proteins at antibodies-online.com

Showing 10 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
Yeast Rabbit His tag   1 mg Log in to see 60 to 71 Days
$2,436.50
Details
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$2,436.50
Details
Yeast Primates His tag   1 mg Log in to see 60 to 71 Days
$2,436.50
Details
Yeast Callithrix jacchus His tag   1 mg Log in to see 60 to 71 Days
$2,436.50
Details
Yeast Rhinoceros His tag   1 mg Log in to see 60 to 71 Days
$2,436.50
Details
Yeast Xenopus tropicalis His tag   1 mg Log in to see 60 to 71 Days
$2,442.00
Details
Yeast REACT_Atlantic Salmon His tag   1 mg Log in to see 60 to 71 Days
$2,442.00
Details

TNFAIP8L2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Tumor Necrosis Factor, alpha-Induced Protein 8-Like 2 (TNFAIP8L2) Interaction Partners

Human Tumor Necrosis Factor, alpha-Induced Protein 8-Like 2 (TNFAIP8L2) interaction partners

  1. the expression of TIPE2 protein could be a predictor of better prognosis for DLBCL.

  2. Insufficient expression of TIPE2 might be involved in the hyperreactivity of monocyte to Toll (show TLR4 Proteins)-like receptor ligands in primary biliary cirrhosis.

  3. data provided the first evidence that TIPE2 inhibits gastric cancer cell migration, invasion and metastasis very probably via reversal of EMT (show ITK Proteins), revealing that TIPE2 may be a novel therapeutic target for human gastric cancer EMT (show ITK Proteins) and metastasis.

  4. Authors demonstrated that TIPE2 overexpression may suppress proliferation, migration, and invasion in prostate cancer cells by inhibiting the PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) signaling pathway.

  5. TIPE2 suppressed breast cancer tumorigenesis, growth and metastasis possibly via regulation of the AKT (show AKT1 Proteins) and p38 (show CRK Proteins) signaling pathways.

  6. these data suggest that TIPE2 overexpression inhibited hypoxia-induced Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathway activation and EMT (show ITK Proteins) in glioma cells.

  7. this study shows that TIPE2 contributes to the pathogenesis of ankylosing spondylitis

  8. TIPE2 expression was significantly decreased in human breast cancer tissue and cell lines. Overexpression of TIPE2 inhibited the proliferation in vitro and tumor xenograft growth in vivo. TIPE2 also inhibited the migration/invasion of breast cancer cells through preventing the epithelial-to-mesenchymal transition (EMT (show ITK Proteins)) phenotype.

  9. Low expression of TIPE2 is associated with hepatocellular carcinogenesis.

  10. our data suggest a previously unappreciated role of TIPE2 in the crosstalk between skin SCC (show CYP11A1 Proteins) and TAMs and highlight TIPE2 as a promising novel target for skin SCC (show CYP11A1 Proteins) treatment.

Mouse (Murine) Tumor Necrosis Factor, alpha-Induced Protein 8-Like 2 (TNFAIP8L2) interaction partners

  1. TIPE2 inhibited breast cancer development and metastasis possibly via promoting CD8 (show CD8A Proteins)(+) T and NK cell-mediated antitumor immune responses

  2. Our current study shows that TIPE2-deficient bone-marrow cells are defective in IL-4 (show IL4 Proteins) induced M2 macrophage differentiation in vitro. TIPE2 promotes phosphoinositide metabolism and the activation of the down-stream AKT (show AKT1 Proteins) signaling pathway, which in turn leads to the expression of markers specific for M2 macrophages.

  3. The present study demonstrates that TIPE2 acts as a novel negative regulator of inflammatory and immune responses through TAK1 (show NR2C2 Proteins) signaling.

  4. Data show that after tumor necrosis factor alpha-induced protein 8 like-2 (TIPE2) gene was down-regulated, the expression of the CD69 antigen (show CD69 Proteins) was increased, and the proliferation of T lymphocytes and the secretion of cytokines IL-2 (show IL2 Proteins) and IFN-gamma (show IFNG Proteins) were enhanced.

  5. TIPE2 alleviates experimental SLE through induction of macrophage polarization to a M2 phenotype, which may be used as a promising therapeutic strategy for treating SLE.

  6. TIPE2 acts as a negative regulator linking NOD2 and inflammatory responses.

  7. TIPE2 plays a suppressive role in injury-induced restenosis and may serve as a new therapeutic target for treating the disease.

  8. Tipe2 provides a molecular bridge between miR (show MLXIP Proteins)-21 and cell apoptosis; miR (show MLXIP Proteins)-21 suppresses apoptosis in activated T cells at least in part through directly targeting tumor suppressor gene Tipe2.

  9. TIPE2 deficiency in hematopoietic cells ameliorates experimental colitis; TIPE2 is a negative regulator of antibacterial immunity, indicating that TIPE2 promotes colitis by inhibiting mucosal immunity to commensal bacteria.

  10. TIPE2 plays a crucial atheroprotective role likely by regulating macrophage responses to oxidized low-density lipoprotein.

Tumor Necrosis Factor, alpha-Induced Protein 8-Like 2 (TNFAIP8L2) Protein Profile

Protein Summary

Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits jun/ap1 and NF-kappa-B activation. Promotes Fas-induced apoptosis (By similarity).

Gene names and symbols associated with TNFAIP8L2

  • tumor necrosis factor, alpha-induced protein 8-like 2 (TNFAIP8L2)
  • tumor necrosis factor, alpha-induced protein 8-like 2 (Tnfaip8l2)
  • tumor necrosis factor, alpha-induced protein 8-like 2 (tnfaip8l2-a)
  • Tumor necrosis factor, alpha-induced protein 8-like protein 2 (tp8l2)
  • 1810019A08Rik protein
  • AW610835 protein
  • RGD1310519 protein
  • TIPE2 protein
  • tnfaip8l2 protein

Protein level used designations for TNFAIP8L2

TNF alpha-induced protein 8-like protein 2 , TNFAIP8-like protein 2 , inflammation factor 20 , inflammation factor protein 20 , tumor necrosis factor alpha-induced protein 8-like protein 2 , tumor necrosis factor, alpha-induced protein 8-like protein 2 , TIPE2 , Tumor necrosis factor, alpha-induced protein 8-like protein 2 , tumor necrosis factor, alpha-induced protein 8-like protein 2 a

GENE ID SPECIES
79626 Homo sapiens
69769 Mus musculus
310663 Rattus norvegicus
510652 Bos taurus
100328663 Oryctolagus cuniculus
399018 Xenopus laevis
100195718 Salmo salar
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