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TYRP1 encodes a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Additionally we are shipping Tyrosinase-Related Protein 1 Antibodies (203) and Tyrosinase-Related Protein 1 Proteins (15) and many more products for this protein.
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a mutation in tyrp1A, one of the two tyrp1 paralogs in zebrafish, causes melanophore death leading to a semi-dominant phenotype
The Fugu tyrp1 promoter can direct transgene expression in a cell-type-specific manner in zebrafish. Our findings provide evidence supporting differential regulations of melanin-synthesizing genes in RPE cells and the NCDM in zebrafish.
we identified some genes that are related to fur formation, including Tyrosinase-related protein 1 (TYRP1) and Tyrosinase (TYR (show TYR ELISA Kits)), as well as genes with unknown functions.
A mutation in exon 2 of the TYRP1 gene leads to a premature stop codon at position 190 of the deduced amino acid sequence. Genotyping 203 rabbits of 32 different breeds identified this mutation only in brown Havana rabbits.
TYRP1-dependent miR-16 (show GDE1 ELISA Kits) sequestration can also be overcome in vivo by using small oligonucleotides that mask miR-16 (show GDE1 ELISA Kits)-binding sites on TYRP1 mRNA.
The mRNA of TYRP1 is now found to sequester the tumour suppressor miR-16 (show GDE1 ELISA Kits).
DNA sequencing showed that the patient has carried compound heterozygous mutations of the tyrosinase related protein (TYRP1) gene, namely c.1214C>A (p.T405N) and c.1333dupG, which were inherited from his mother and father, respectively.
Single nucleotide polymorphisms in TYRP1 gene is associated with multiple primary melanoma.
Mutation in TYRP1 is associated with oculocutaneous albinism.
Polymorphisms in 3'UTR (show UTS2R ELISA Kits) of TYRP1 mRNA can affect TYRP1 mRNA regulation by miR (show MLXIP ELISA Kits)-155 and its subsequent translation into protein. These SNPs can render TYRP1 mRNA and protein expression nonsusceptible to miR (show MLXIP ELISA Kits)-155 activity
These data suggest that UVB-stimulated Ucn1 (show UCN ELISA Kits) contributes to TRP1 (show PRSS1 ELISA Kits) production via the transcription of both Nurr-1 (show NR4A2 ELISA Kits) and Nur77 (show NR4A1 ELISA Kits). Ucn1 (show UCN ELISA Kits), produced in melanoma cells, acts on melanoma cells themselves in an autocrine manner.
These data indicate that galectin-3 (show LGALS3 ELISA Kits) is a regulatory component in melanin synthesis affecting the expression of Tyrp-1.
p53 (show TP53 ELISA Kits) regulation by TRP2 (show DCT ELISA Kits) is not pervasive in melanoma.
Due to mutation in Tyrp1 protein, it became more rigid and might disturb the structural conformation and catalytic function of the structure and might also play a significant role in inducing oculocutaneous albinism type III.
A 6-bp deletion in the TYRP1 gene causes the brown colouration phenotype in Chinese indigenous pigs.
Sequence analysis revealed variation in the TYRP1 (exon 5) and MC1R genes; restriction enzyme analysis of these two genes could distinguish between different colours of Hanwoo cattle.
Genetic modulators of IOP thus may be independently identified using the full array of BXD mice without concern for the presence of transillumination defect or mutations in Typr1 and/or Gpnmb.
the results from the present study demonstrate that the MA extract increases melanogenesis through the upregulation of TRP-1 (show TRPC1 ELISA Kits) protein expression by post-transcriptional control in B16F10 cells
Studied upregulation by Kaliziri extract of tyrosinase (show TYR ELISA Kits), TRP-1 (show TRPC1 ELISA Kits), TRP-2 (show DCT ELISA Kits) and MITF (show MITF ELISA Kits) expression in murine B16 melanoma cells.
The SNARE (show VTI1B ELISA Kits) machinery composed of VAMP7 (show VAMP7 ELISA Kits) on Tyrp1-containing vesicles and syntaxin-3 (show STX3 ELISA Kits) and SNAP23 (show SNAP23 ELISA Kits) on melanosomes regulates Tyrp1 trafficking to the melanosome in melanocytes.
Addition of a TRP-1 (show TRPC1 ELISA Kits)-directed monoclonal antibody to the treatment protocol for B16F10 skin melanoma mediates eradication of subcutaneous lesions.
analysis of tyrosinase-related protein 1 in mouse melanocytes at early embryonic stage
GILT (show IFI30 ELISA Kits)-deficient mice have an increase in TRP1 (show TRPC1 ELISA Kits)-specific regulatory T (Treg) cells compared with TRP1 (show TRPC1 ELISA Kits)-deficient mice, and depletion of Treg cells partially restores the ability of GILT (show IFI30 ELISA Kits)-deficient TRP1 (show TRPC1 ELISA Kits)-specific CD4 (show CD4 ELISA Kits)(+) T cells to induce vitiligo (show MITF ELISA Kits).
The Tyrp1b mutation modifies the pathways and gene networks in which Tyrp1 functions.
DNA vaccination with a melanoma-shared antigen Trp1 (show TRPC1 ELISA Kits), combined with systemic TGF-beta (show TGFB1 ELISA Kits) blockade during the perioperative period of primary tumor resection, confers protection against B16 melanoma.
both the Rab32 (show RAB32 ELISA Kits)/38 binding activity and VAMP7 (show VAMP7 ELISA Kits) binding activity of Varp (show ANKRD27 ELISA Kits) are essential for trafficking of Tyrp1 in melanocytes but activation of Rab21 (show RAB21 ELISA Kits) by the VPS9 domain is not necessary for Tyrp1 trafficking
This gene encodes a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Defects in this gene are the cause of rufous oculocutaneous albinism and oculocutaneous albinism type III.
5,6-dihydroxyindole-2-carboxylic acid oxidase
, tyrosinase-related protein 1
, 5,6-dihydroxyindole-2-carboxylic acid oxidase-like
, short transient receptor potential channel 1
, transient receptor protein 1
, DHICA oxidase
, catalase B
, glycoprotein 75
, melanoma antigen gp75
, tyrosinase-related protein-1
, brown locus protein
, iris stromal atrophy
, tyrosine phosphatase 1, same as B (Brown)