Tyrosine-Protein Phosphatase Non-Receptor Type 22 Proteins (PTPN22)

PTPN22 encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. Additionally we are shipping PTPN22 Antibodies (65) and PTPN22 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PTPN22 19260 P29352
PTPN22 26191 Q9Y2R2
PTPN22 295338  
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top PTPN22 Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$11,073.30
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$11,073.30
Details
HOST_Escherichia coli (E. coli) Human T7 tag,His tag   100 μg Log in to see 15 to 18 Days
$576.00
Details
HOST_Escherichia coli (E. coli) Rat T7 tag,His tag   100 μg Log in to see 15 to 18 Days
$640.00
Details

PTPN22 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
, ,
Rat (Rattus)

Top referenced PTPN22 Proteins

  1. Human PTPN22 Protein expressed in Wheat germ - ABIN1316837 : Bayley, Yang, Buckley, Young: Measuring the specific activity of the protein tyrosine phosphatase Lyp. in Journal of immunological methods 2013 (PubMed)

More Proteins for Tyrosine-Protein Phosphatase Non-Receptor Type 22 (PTPN22) Interaction Partners

Mouse (Murine) Tyrosine-Protein Phosphatase Non-Receptor Type 22 (PTPN22) interaction partners

  1. PTPN22 deficiency resulted in pronounced colitis, increased NLRP3 (show NLRP3 Proteins) phosphorylation, but reduced levels of mature IL-1beta (show IL1B Proteins).

  2. We show that PTPN22 deficiency enhanced T-cell receptor-mediated signaling in SKG Ptpn22-/- thymocytes and that the early stages of thymus positive selection were partially restored in SKG Ptpn22-/- mice.

  3. this study shows that neutrophil effector functions are reduced in Ptpn22-/- neutrophils, and that Ptpn22-/- mice are protected from immune complex-mediated arthritis

  4. report demonstrates enhanced T1D in a mouse modeling human PTPN22(R620W) and the utility of CRISPR-Cas9 for direct genetic alternation of NOD mice.

  5. our data suggest a critical role for GITR (show TNFRSF18 Proteins) in Treg cell homeostasis and indicate that Ptpn22 independently affects the differentiation status of Treg cells and their homeostatic behavior

  6. Tec (show NR4A3 Proteins) enhances c-Maf (show MAF Proteins)-dependent IL-4 (show IL4 Proteins) promoter activity. This effect of Tec (show NR4A3 Proteins) is counteracted by Ptpn22, which physically interacts with and facilitates tyrosine dephosphorylation of c-Maf (show MAF Proteins) thereby attenuating its transcriptional activity.

  7. lack of PTPN22 strengthens transplant tolerance to pancreatic islets by expanding both FOXP3(+) Treg and Tr1 cells

  8. Ptpn22 and Cd2 (show CCND2 Proteins) Variations Are Associated with Altered Protein Expression and Susceptibility to Type 1 Diabetes

  9. T cell activation modulates the expression of PTPN22 and additional inhibitory phosphatases.

  10. PTPN22 is an inhibitor of PAD-4 (show PADI4 Proteins) and protein citrullination.

Human Tyrosine-Protein Phosphatase Non-Receptor Type 22 (PTPN22) interaction partners

  1. The associations observed between PTPN22 (C1858T) and the risk of endometriosis suggest this polymorphism might be a useful susceptibility marker for this disease.

  2. PTPN22 deficiency resulted in pronounced colitis, increased NLRP3 (show NLRP3 Proteins) phosphorylation, but reduced levels of mature IL-1beta (show IL1B Proteins).

  3. the coding regions of 17 genes involved in the regulation of the immune response were determined by massive parallel sequencing. The analysis revealed 39 nonsynonymous SNPs that lead to amino acid substitutions, including the following informative genetic markers: PTPN22 c.1858C>T (rs2476601), TLR4 (show TLR4 Proteins) c.896A>G (rs4986790) and TLR4 (show TLR4 Proteins) c.1196C>T (rs4986791), IL7R (show IL7R Proteins) c.197T>C (rs1494555) and IL7R (show IL7R Proteins) c.412G>A (rs1494558).

  4. PTPN22 variants are associated with ANCA-associated vasculitis risk.

  5. C1858T polymorphism of protein tyrosine phosphatase (show ACP1 Proteins) non-receptor type 22 characterizes a subset of type 1 diabetic patients with higher levels of C-peptide at diagnosis and lower insulin (show INS Proteins) requirement at 6 months from diagnosis.

  6. The presence of PTPN22 1858C-->T polymorphism with HLA shared epitope and autoantibodies increases risk of rheumaotid arthritis development and erosive disease.

  7. for the first time addressed how presence of SNP rs2476601 within the PTPN22 gene affects clinical characteristics in IBD-patients. Several factors that correlate with more severe disease were found to be less common in CD patients carrying the A-allele, pointing towards a protective role for this variant in affected CD patients

  8. A significant association was found between the rs2476601 polymorphism of the PTPN22 gene and cystic fibrosis (show S100A8 Proteins) in Mexican patients

  9. The PTPN22 R620W minor allele frequency was increased in IIM patients (50 of 398, 12.6%) compared with controls.

  10. This study reveals a significant association between SNPs in PTPN22, CTLA-4 gene and AR with asthma in Chinese Han children, which might be susceptibility factors for Allergic rhinitis and asthma.

PTPN22 Protein Profile

Protein Summary

This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described.

Gene names and symbols associated with PTPN22

  • protein tyrosine phosphatase, non-receptor type 22 (lymphoid) (Ptpn22)
  • protein tyrosine phosphatase, non-receptor type 22 (lymphoid) (PTPN22)
  • 70zpep protein
  • LYP protein
  • LYP1 protein
  • LYP2 protein
  • PEP protein
  • PTPN8 protein

Protein level used designations for PTPN22

PEST domain-enriched tyrosine phosphatase , hematopoietic cell protein-tyrosine phosphatase 70Z-PEP , protein tyrosine phosphatase, non-receptor type 8 , tyrosine-protein phosphatase non-receptor type 22 , PEST-domain phosphatase , lymphoid phosphatase , lymphoid-specific protein tyrosine phosphatase

GENE ID SPECIES
19260 Mus musculus
26191 Homo sapiens
295338 Rattus norvegicus
Selected quality suppliers for PTPN22 Proteins (PTPN22)
Did you look for something else?