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U2 auxiliary factor (U2AF), comprised of a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. Additionally we are shipping U2 Small Nuclear RNA Auxiliary Factor 2 Proteins (3) and many more products for this protein.
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Cow (Bovine) Polyclonal U2AF59 Primary Antibody for WB - ABIN2778722
Sickmier, Frato, Kielkopf: Crystallization and preliminary X-ray analysis of a U2AF65 variant in complex with a polypyrimidine-tract analogue by use of protein engineering. in Acta crystallographica. Section F, Structural biology and crystallization communications 2006
Perturbation of U2AF65/NXF1-mediated RNA nuclear export enhances RNA tox (show NXF1 Antibodies)icity in polyQ diseases.
dephosphorylation of pS776-ATXN1 (show ATXN1 Antibodies) by PP2A (show PPP2R2B Antibodies) regulates the interaction of ATXN1 (show ATXN1 Antibodies) with the splicing factors RBM17 (show RBM17 Antibodies) and U2AF65
Using a yeast two-hybrid system, we found fourteen U2AF(65)-interacting proteins. The validity of the screen was confirmed by identification of five known U2AF(65)-interacting proteins, including its heterodimeric partner, U2AF(35 (show U2AF1 Antibodies)).
In vivo binding of U2AF(65) to a polypyrimidine tract requires a flexible RNA backbone.
These findings uncovered a hitherto unappreciated function of CD82 (show CD82 Antibodies) in severing the linkage between U2AF2-mediated CD44 (show CD44 Antibodies) alternative splicing and cancer aggressiveness, with potential prognostic and therapeutic implications in melanoma
JMJD6 (show JMJD6 Antibodies) regulated a large set of alternative splicing events, and importantly, its regulated splicing events were significantly overlapped those controlled by U2AF65.
This study therefore establishes a structural basis for specific UHM-ULM interactions by splicing factors such as U2AF35 (show U2AF1 Antibodies), U2AF65, RBM39 (show RBM39 Antibodies) and SF3b155 (show SF3B1 Antibodies), and a platform for continued studies of intermolecular interactions governing disease-related alternative splicing in eukaryotic cells.
The U2AF(65) linker residues between the dual RNA recognition motifs (RRMs) recognize the central nucleotide, whereas the N- and C-terminal RRM extensions recognize the 3' terminus and third nucleotide.
Nuclear retention of full-length HTT (show HTT Antibodies) RNA is mediated by splicing factors MBNL1 (show MBNL1 Antibodies) and U2AF65
U2AF(65) possesses a splicing Inhibitory function that leads to alternative exon skipping.
The spatial distribution of U2AF65 conformations is found to be highly anisotropic, comprising significantly populated interdomain contacts that appear to be electrostatic in origin.
reduced U2AF(65) binding is a molecular consequence of disease-relevant mutations, and a structure-guided U2AF(65) variant is capable of manipulating gene expression in eukaryotic cells
We demonstrated that PRPF40B interacts directly with SF1 and associates with U2AF(65
U2AF65 represents a new route for modulating TRF1 (show TERF1 Antibodies) function at telomeres.
U2 auxiliary factor (U2AF), comprised of a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the U2AF large subunit which contains a sequence-specific RNA-binding region with 3 RNA recognition motifs and an Arg/Ser-rich domain necessary for splicing. The large subunit binds to the polypyrimidine tract of introns early during spliceosome assembly. Multiple transcript variants have been detected for this gene, but the full-length natures of only two have been determined to date.
U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2
, U2 small nuclear RNA auxiliary factor 2
, RNA-binding region RNP-1 domain-containing protein
, U2 snRNP auxiliary factor large subunit
, Splicing factor U2AF 65 kDa subunit
, U2 auxiliary factor 65 kDa subunit
, U2 small nuclear ribonucleoprotein auxiliary factor (U2AF), 65 kDa
, splicing factor U2AF 65 kDa subunit
, splicing factor U2AF large chain
, U2 (RNU2) small nuclear RNA auxiliary factor 2
, U2 small nuclear ribonucleoprotein auxiliary factor (65kD)