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UVRAG complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. Additionally we are shipping UVRAG Antibodies (95) and many more products for this protein.
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The UVRAG-containing PI3K (III) complex is required for receptor downregulation through endolysosomal degradation and for the establishment of proper cell polarity in the developing wing.
UVRAG-mutated heterotaxy patient cells also display highly increased Notch (show NOTCH1 Proteins) protein levels
UVRAG frameshift is expressed as a truncated protein in colorectal cancer with microsatellite instability and promotes tumorigenesis. UVRAG(FS) expression renders cells more sensitive to standard chemotherapy regimen due to a DNA repair defect.
HCV, by differentially inducing the expression of Rubicon (show KIAA0226 Proteins) and UVRAG, temporally regulated the autophagic flux to enhance its replication.
tubulation requires mTOR (show FRAP1 Proteins) activity, and we identified two direct mTOR (show FRAP1 Proteins) phosphorylation sites on UVRAG (S550 and S571) that activate VPS34 (show PIK3C3 Proteins).
Beclin 1 (show BECN1 Proteins) and UVRAG confer protection against radiation-induced DNA DNA double strand breaks and may maintain centrosome stability in established tumor cells.
Dephosphorylation of UVRAG facilitates the lysosomal degradation of epidermal growth factor receptor (EGFR (show EGFR Proteins)), reduces EGFR (show EGFR Proteins) signaling, and suppresses cancer cell proliferation and tumor growth.
The reports that Grb2 (show GRB2 Proteins), when in excess (show RCC1 Proteins), interacts with ultraviolet radiation resistance-associated gene protein (UVRAG) under excess conditions of AICD-Grb2 (show GRB2 Proteins) or Grb2 (show GRB2 Proteins).
UVRAG is required for virus entry through combinatorial interaction with the class C-Vps complex and SNAREs.
Akt1 (show AKT1 Proteins) may inhibit autophagy by decreasing UVRAG expression, which also sensitizes cancer cells to UV irradiation.
in Escherichia coli-containing phagosomes of mouse macrophages, Slamf1 (show SLAMF1 Proteins) interacts with the class III PI3K (show PIK3CA Proteins) Vps34 (show PIK3C3 Proteins) in a complex with Beclin-1 (show BECN1 Proteins) and UVRAG
UVRAG promotes DNA double-strand-break repair by directly binding and activating DNA-PK in nonhomologous end joining. Disruption of UVRAG increases genetic instability and sensitivity of cells to irradiation.
Beclin 1 (show BECN1 Proteins) regulates endosome pathways via the UVRAG-VPS34 (show PIK3C3 Proteins) complex.
EWSR1 (show EWSR1 Proteins) is involved in the post-transcriptional regulation of Uvrag via a miRNA-dependent pathway, resulting in the deregulation of autophagy inhibition.
silencing of UVRAG significantly attenuated the antimicrobial effects of macrophages against M. tuberculosis.
data provide novel insights into the control of autophagy in T cells and identify UVRAG as a new regulator of naive peripheral T-cell homeostasis.
in Escherichia coli-containing phagosomes of mouse macrophages, Slamf1 (show SLAMF1 Proteins) interacts with the class III PI3K Vps34 (show PIK3C3 Proteins) in a complex with Beclin-1 (show BECN1 Proteins) and UVRAG
UVRAG has cytoprotective functions in the cytosol that control the localization of Bax (show BAX Proteins) in tumor cells exposed to apoptotic stimuli
through ultraviolet irradiation resistance-associated gene (UVRAG), Bif-1 (show SH3GLB1 Proteins) interacts with Beclin 1 (show BECN1 Proteins) and functions as a positive mediator of the class III PI(3 (show PI3 Proteins)) kinase (PI(3 (show PI3 Proteins))KC3).
These results suggest that mammalian cells have at least two distinct class III PI3-kinase (show PIK3CA Proteins) complexes, and that beclin 1 (show BECN1 Proteins) interacts distinctly with mammalian Atg14 and UVRAG in two of these complexes.
This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer.
, UV radiation resistance associated gene
, UV radiation resistance-associated gene protein
, UV radiation resistance associated
, UV radiation resistance-associated gene protein-like
, beclin 1 binding protein
, disrupted in heterotaxy