You are viewing an incomplete version of our website. Please click to reload the website as full version.

UV Radiation Resistance Associated Gene Proteins (UVRAG)

UVRAG complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. Additionally we are shipping UVRAG Antibodies (92) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat UVRAG UVRAG 361609  
UVRAG 7405 Q9P2Y5
Mouse UVRAG UVRAG 78610  
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top UVRAG Proteins at antibodies-online.com

Showing 2 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

UVRAG Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,

More Proteins for UV Radiation Resistance Associated Gene (UVRAG) Interaction Partners

Fruit Fly (Drosophila melanogaster) UV Radiation Resistance Associated Gene (UVRAG) interaction partners

  1. The UVRAG-containing PI3K (III) complex is required for receptor downregulation through endolysosomal degradation and for the establishment of proper cell polarity in the developing wing.

  2. UVRAG-mutated heterotaxy patient cells also display highly increased Notch (show NOTCH1 Proteins) protein levels

Human UV Radiation Resistance Associated Gene (UVRAG) interaction partners

  1. UVRAG frameshift is expressed as a truncated protein in colorectal cancer with microsatellite instability and promotes tumorigenesis. UVRAG(FS) expression renders cells more sensitive to standard chemotherapy regimen due to a DNA repair defect.

  2. HCV, by differentially inducing the expression of Rubicon (show KIAA0226 Proteins) and UVRAG, temporally regulated the autophagic flux to enhance its replication.

  3. tubulation requires mTOR (show FRAP1 Proteins) activity, and we identified two direct mTOR (show FRAP1 Proteins) phosphorylation sites on UVRAG (S550 and S571) that activate VPS34 (show PIK3C3 Proteins).

  4. Beclin 1 (show BECN1 Proteins) and UVRAG confer protection against radiation-induced DNA DNA double strand breaks and may maintain centrosome stability in established tumor cells.

  5. Dephosphorylation of UVRAG facilitates the lysosomal degradation of epidermal growth factor receptor (EGFR (show EGFR Proteins)), reduces EGFR (show EGFR Proteins) signaling, and suppresses cancer cell proliferation and tumor growth.

  6. The reports that Grb2 (show GRB2 Proteins), when in excess (show RCC1 Proteins), interacts with ultraviolet radiation resistance-associated gene protein (UVRAG) under excess conditions of AICD-Grb2 (show GRB2 Proteins) or Grb2 (show GRB2 Proteins).

  7. UVRAG is required for virus entry through combinatorial interaction with the class C-Vps complex and SNAREs.

  8. Akt1 (show AKT1 Proteins) may inhibit autophagy by decreasing UVRAG expression, which also sensitizes cancer cells to UV irradiation.

  9. in Escherichia coli-containing phagosomes of mouse macrophages, Slamf1 (show SLAMF1 Proteins) interacts with the class III PI3K (show PIK3CA Proteins) Vps34 (show PIK3C3 Proteins) in a complex with Beclin-1 (show BECN1 Proteins) and UVRAG

  10. UVRAG promotes DNA double-strand-break repair by directly binding and activating DNA-PK in nonhomologous end joining. Disruption of UVRAG increases genetic instability and sensitivity of cells to irradiation.

Mouse (Murine) UV Radiation Resistance Associated Gene (UVRAG) interaction partners

  1. Beclin 1 (show BECN1 Proteins) regulates endosome pathways via the UVRAG-VPS34 (show PIK3C3 Proteins) complex.

  2. EWSR1 (show EWSR1 Proteins) is involved in the post-transcriptional regulation of Uvrag via a miRNA-dependent pathway, resulting in the deregulation of autophagy inhibition.

  3. tubulation requires mTOR (show FRAP1 Proteins) activity, and we identified two direct mTOR (show FRAP1 Proteins) phosphorylation sites on UVRAG (S550 and S571) that activate VPS34 (show PIK3C3 Proteins).

  4. silencing of UVRAG significantly attenuated the antimicrobial effects of macrophages against M. tuberculosis.

  5. data provide novel insights into the control of autophagy in T cells and identify UVRAG as a new regulator of naive peripheral T-cell homeostasis.

  6. in Escherichia coli-containing phagosomes of mouse macrophages, Slamf1 (show SLAMF1 Proteins) interacts with the class III PI3K Vps34 (show PIK3C3 Proteins) in a complex with Beclin-1 (show BECN1 Proteins) and UVRAG

  7. UVRAG has cytoprotective functions in the cytosol that control the localization of Bax (show BAX Proteins) in tumor cells exposed to apoptotic stimuli

  8. through ultraviolet irradiation resistance-associated gene (UVRAG), Bif-1 (show SH3GLB1 Proteins) interacts with Beclin 1 (show BECN1 Proteins) and functions as a positive mediator of the class III PI(3 (show PI3 Proteins)) kinase (PI(3 (show PI3 Proteins))KC3).

  9. These results suggest that mammalian cells have at least two distinct class III PI3-kinase (show PIK3CA Proteins) complexes, and that beclin 1 (show BECN1 Proteins) interacts distinctly with mammalian Atg14 and UVRAG in two of these complexes.

UVRAG Protein Profile

Protein Summary

This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer.

Gene names and symbols associated with UVRAG

  • UV-resistance associated gene (Uvrag)
  • UV radiation resistance associated gene (uvrag)
  • UV radiation resistance associated gene (UVRAG)
  • UV radiation resistance associated gene (Uvrag1)
  • UV radiation resistance associated (UVRAG)
  • UV radiation resistance associated gene (Uvrag)
  • 9530039D02Rik protein
  • AI648770 protein
  • BB124205 protein
  • CG6116 protein
  • DHTX protein
  • Dmel\\CG6116 protein
  • MGC81810 protein
  • MGC131135 protein
  • p63 protein
  • uvrag protein
  • Uvrag1 protein
  • Uvragl protein
  • VPS38 protein
  • zgc:56164 protein

Protein level used designations for UVRAG

CG6116-PA , CG6116-PB , UV radiation resistance associated gene , Uvrag-PA , Uvrag-PB , UV radiation resistance-associated gene protein , UV radiation resistance associated , UV radiation resistance-associated gene protein-like , beclin 1 binding protein , disrupted in heterotaxy

GENE ID SPECIES
34735 Drosophila melanogaster
394044 Danio rerio
614285 Bos taurus
696601 Macaca mulatta
779151 Xenopus laevis
361609 Rattus norvegicus
735238 Xenopus laevis
100413829 Callithrix jacchus
100477039 Ailuropoda melanoleuca
100486296 Xenopus (Silurana) tropicalis
100544950 Meleagris gallopavo
100552937 Anolis carolinensis
100595542 Nomascus leucogenys
100051722 Equus caballus
100354086 Oryctolagus cuniculus
100443180 Pongo abelii
7405 Homo sapiens
78610 Mus musculus
419091 Gallus gallus
451430 Pan troglodytes
607998 Canis lupus familiaris
308846 Rattus norvegicus
Selected quality suppliers for UVRAG Proteins (UVRAG)
Did you look for something else?