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anti-Ubiquilin 2 (UBQLN2) Antibodies

UBQLN2 encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Additionally we are shipping Ubiquilin 2 Kits (7) and Ubiquilin 2 Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
UBQLN2 29978 Q9UHD9
UBQLN2 54609 Q9QZM0
UBQLN2 317396  
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Top anti-Ubiquilin 2 Antibodies at antibodies-online.com

Showing 10 out of 46 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-UBQLN2 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: HepG2 cell lysate WB Suggested Anti-UBQLN2  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:1562500  Positive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated IF, ELISA, WB Immunofluorescence of monoclonal antibody to UBQLN2 on A-431 cell. [antibody concentration 10 ug/ml] UBQLN2 monoclonal antibody (M03), clone 5F5 Western Blot analysis of UBQLN2 expression in A-431 . 100 μg Log in to see 9 Days
$430.00
Details
Human Mouse Un-conjugated ICC, IF, IHC, WB Western blot analysis of untransfected primary mouse neuron and glia cell cultures (lane 1), the same cells transduced with human ubiquilin 2 wild type (lane 2), with ubiquilin 2 P506T mutant (lane 3), with ubiquilin 2 P497S mutant (lane 4) and with enhanced GFP control (lane 5), all probed with ABIN1580461. Also seen is ABIN1580461 staining in HeLa cells (lane 6) and 3T3 cells (lane 7). In primary mouse neuron and glia cell culture, endogenous ubiquilin 2 appears as a weak band at 68 kDa in all transduced and non-transduced cells, indicating low endogenous expression of mouse ubiquilin 2. Strong bands are seen in the cells transduced with human wild type or mutant ubiquilin 2. Small proteins run at 50 kDa in these cells are the fragments of ubiquilin 2. Note, ubiquilin 2 run at ~66 kDa in human HeLa cells and 68 kDa in rodent 3T3 cells. HeLa cell cultures stained with ABIN1580461 (green) and ’s chicken polyclonal antibody to vimentin: CPCA-Vim (red). In most individual cells ubiquilin 2 is present diffusely in the cytoplasm of cells, though some cells show enrichment of the protein in spherical autophagosome-like structure. 100 μL Log in to see 2 to 3 Days
$220.00
Details
Human Mouse Un-conjugated IF, WB Immunofluorescence of monoclonal antibody to UBQLN2 on A-431 cell (antibody concentration 10 µg/mL). UBQLN2 monoclonal antibody (M03), clone 5F5 Western Blot analysis of UBQLN2 expression in A-431. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit APC ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Mouse Un-conjugated ELISA, WB UBQLN2 polyclonal antibody (A01), Lot # 061101JCS1 Western Blot analysis of UBQLN2 expression in Jurkat . Western Blot detection against Immunogen (33.81 KDa) . 50 μL Log in to see 9 Days
$298.57
Details
Human Rabbit Un-conjugated ELISA   200 μL Log in to see 8 to 10 Days
$713.17
Details

UBQLN2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human ,
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Mouse (Murine)


Rat (Rattus)
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Top referenced anti-Ubiquilin 2 Antibodies

  1. Human Monoclonal UBQLN2 Primary Antibody for IF, ELISA - ABIN565449 : Al-Sarraj, King, Troakes, Smith, Maekawa, Bodi, Rogelj, Al-Chalabi, Hortobágyi, Shaw: p62 positive, TDP-43 negative, neuronal cytoplasmic and intranuclear inclusions in the cerebellum and hippocampus define the pathology of C9orf72-linked FTLD and MND/ALS. in Acta neuropathologica 2011 (PubMed)
    Show all 10 references for ABIN565449

  2. Human Monoclonal UBQLN2 Primary Antibody for ICC, IF - ABIN1580461 : NDiaye, Kajihara, Hsieh, Morisaki, Debnath, Brown: PLIC proteins or ubiquilins regulate autophagy-dependent cell survival during nutrient starvation. in EMBO reports 2009 (PubMed)
    Show all 6 references for ABIN1580461

  3. Human Polyclonal UBQLN2 Primary Antibody for EIA, WB - ABIN357610 : Walters, Kleijnen, Goh, Wagner, Howley: Structural studies of the interaction between ubiquitin family proteins and proteasome subunit S5a. in Biochemistry 2002 (PubMed)
    Show all 3 references for ABIN357610

  4. Human Polyclonal UBQLN2 Primary Antibody for EIA, IHC (p) - ABIN357609 : Ueki, Oda, Kondo, Yano, Noguchi, Muramatsu: Selection system for genes encoding nuclear-targeted proteins. in Nature biotechnology 1999 (PubMed)
    Show all 3 references for ABIN357609

More Antibodies against Ubiquilin 2 Interaction Partners

Human Ubiquilin 2 (UBQLN2) interaction partners

  1. UBQLN2 is specifically expressed in the urine of urothelial carcinoma patients.

  2. Results showed that UBQLN2 is selectively recruited to nuclear inclusions in Huntington's disease but not spinocerebellar ataxia (show USP14 Antibodies) type 3

  3. These findings provide a molecular basis for the development of ALS/FTD-associated proteinopathy and establish novel therapeutic targets for ALS.

  4. Mutations in UBQLN2 gene cause dominant inheritance of amyotrophic lateral sclerosis due to Defective Proteasome Delivery.

  5. UBQLN2 may be a new molecular target for chemotherapeutics and a useful clinicopathological marker in human osteosarcoma.

  6. ALS (show IGFALS Antibodies)-linked mutations in ubiquilin-2 or hnRNPA1 (show HNRNPA1 Antibodies) reduce interaction between ubiquilin-2 and hnRNPA1 (show HNRNPA1 Antibodies)

  7. ALS (show IGFALS Antibodies)-linked mutations in both OPTN (show OPTN Antibodies) and UBQLN2 interfere with the constitution of specific endosomal vesicles, suggesting that the vesicles are involved in protein homeostasis and that these proteins function in common pathological processes.

  8. A single putative mutation of UBQLN2 in a cohort of patients with front temporal lobar degeneration was found.

  9. Data indicate cognitive deficits in mutant ubiquilin 2 protein UBQLN2P497H transgenic mice.

  10. Causative mutation in the UBQLN2 gene is rare in Korean patients with either familial or sporadic ALS.

Mouse (Murine) Ubiquilin 2 (UBQLN2) interaction partners

  1. Results showed that UBQLN2 is selectively recruited to nuclear inclusions in Huntington's disease but not spinocerebellar ataxia (show USP14 Antibodies) type 3

  2. UBQLN2 dysregulation in neurons can drive NF-kappaB (show NFKB1 Antibodies) activation and cytosolic TDP-43 (show TARDBP Antibodies) aggregation.

  3. Transduction of UBQLN2 mutants (P497H, P497S, and P506T) induce proteinopathy and cause behavioral deficits, supporting a "toxic" gain-of-function amyotrophic lateral sclerosis model, in mice.

  4. results were confirmed by similar findings for ubiquilin-1 (show UBQLN1 Antibodies) and -2 in human brain tissue sections, where accumulation was observed in huntingtin (show HTT Antibodies) inclusions

  5. UBQLN2-transfected cells did not show increased starvation-induced cell death.

Ubiquilin 2 (UBQLN2) Antigen Profile

Protein Summary

This gene encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases\; and thus, are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to bind the ATPase domain of the Hsp70-like Stch protein.

Gene names and symbols associated with anti-Ubiquilin 2 (UBQLN2) Antibodies

  • ubiquilin 1 (ubqln1) antibody
  • ubiquilin 2 (UBQLN2) antibody
  • ubiquilin 2 (LOC100347089) antibody
  • ubiquilin 2 (Ubqln2) antibody
  • ALS15 antibody
  • Chap1 antibody
  • da41 antibody
  • Dsk2 antibody
  • HRIHFB2157 antibody
  • N4BP4 antibody
  • plic-1 antibody
  • Plic-2 antibody
  • Plic2 antibody
  • RGD1563566 antibody
  • UBQLN2 antibody
  • ubqn antibody
  • xdrp1 antibody

Protein level used designations for anti-Ubiquilin 2 (UBQLN2) Antibodies

ubiquilin 2 , ubiquilin-2 , Nedd4 binding protein 4 , protein linking IAP with cytoskeleton 2 , ubiquitin-like product Chap1/Dsk2 , Ubiquitin-related protein

GENE ID SPECIES
394829 Xenopus (Silurana) tropicalis
419078 Gallus gallus
446997 Xenopus laevis
491909 Canis lupus familiaris
539529 Bos taurus
743819 Pan troglodytes
100347089 Oryctolagus cuniculus
29978 Homo sapiens
54609 Mus musculus
317396 Rattus norvegicus
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