anti-Ubiquitin Specific Peptidase 15 (USP15) Antibodies

USP15 encodes a member of the ubiquitin specific protease (USP) family of deubiquitinating enzymes. Additionally we are shipping USP15 Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
USP15 9958 Q9Y4E8
USP15 14479 Q8R5H1
USP15 171329  
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Top anti-USP15 Antibodies at antibodies-online.com

Showing 10 out of 89 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB USP15 Antibody (N-term) (ABIN658273) western blot analysis in mouse cerebellum tissue lysates (35 µg/lane). This demonstrates the USP15 antibody detected the USP15 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Cow Rabbit Un-conjugated IF, WB WB Suggested Anti-USP15 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: Jurkat cell lysate Immunofluorescence Sample Type: A549&HEK293T cellsPrimary Dilution: 1:500 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Goat Un-conjugated IHC, ELISA, WB   100 μg Log in to see 6 to 7 Days
$326.89
Details
Human Goat Un-conjugated IHC (p), IHC, ELISA Immunohistochemistry-Paraffin: USP15 Antibody [ABIN249918] - 3.8ug/ml staining of paraffin embedded Human Liver. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. 0.1 mg Log in to see 7 to 9 Days
$408.19
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), IP, WB Western Blot: USP15 Antibody [ABIN2582840] - Whole cell lysate (50 ug) from NIH3T3, TCMK-1, 4T1, CT26.WT, and rat C6 cells. 100 μL Log in to see 7 to 9 Days
$486.94
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Mouse Un-conjugated IF, WB 0.1 mg Log in to see 3 to 4 Days
$601.76
Details
Human Rabbit Un-conjugated WB The anti-USP15 Pab (ABIN388904) is used in Western blot to detect USP15 in mouse brain tissue lysate. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB WB Image Sample (30 ug of whole cell lysate) A: NIH-3T3 B: JC C: BCL-1 7.5% SDS PAGE antibody diluted at 1:1000 ICC/IF Image Immunofluorescence analysis of paraformaldehyde-fixed A431, using USP15, antibody at 1:200 dilution. 100 μL Log in to see 1 to 2 Days
$358.60
Details
Cow Goat Un-conjugated EIA, IHC (p) Staining of paraffin embedded Human Liver using USP15 antibody at 2 µg/ml. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining. 0.1 mg Log in to see 6 to 8 Days
$390.50
Details

USP15 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-USP15 Antibodies

  1. Human Polyclonal USP15 Primary Antibody for WB - ABIN658273 : Vos, Altreuter, White, Howley: The ubiquitin-specific peptidase USP15 regulates human papillomavirus type 16 E6 protein stability. in Journal of virology 2009 (PubMed)
    Show all 3 references for 658273

  2. Human Polyclonal USP15 Primary Antibody for ICC, IF - ABIN258284 : Isumi, Hirata, Saitoh, Miyakawa, Murakami, Kudoh, Doi, Ishibashi, Nakajima: Transgenic overexpression of USP15 in the heart induces cardiac remodeling in mice. in Biochemical and biophysical research communications 2011 (PubMed)
    Show all 2 references for 258284

  3. Human Monoclonal USP15 Primary Antibody for IF, WB - ABIN2477039 : Miyauchi, Kato, Tokunaga, Iwai: The COP9/signalosome increases the efficiency of von Hippel-Lindau protein ubiquitin ligase-mediated hypoxia-inducible factor-alpha ubiquitination. in The Journal of biological chemistry 2008 (PubMed)

  4. Human Polyclonal USP15 Primary Antibody for IHC (p), IHC - ABIN249918 : Baker, Wang, Woollatt, White, Sutherland et al.: Identification, functional characterization, and chromosomal localization of USP15, a novel human ubiquitin-specific protease related to the UNP oncoprotein, and a systematic nomenclature for human ... in Genomics 1999 (PubMed)

More Antibodies against USP15 Interaction Partners

Human Ubiquitin Specific Peptidase 15 (USP15) interaction partners

  1. We show that PRP31 (show PRPF31 Antibodies), a component of U4 snRNP (show LSM2 Antibodies), is modified with K63-linked ubiquitin chains by the PRP19 (show PRPF19 Antibodies) complex and deubiquitinated by USP15 and its substrate targeting factor SART3 (show SART3 Antibodies). USP15SART3 makes a complex with USP4 (show USP4 Antibodies) and this ternary complex serves as a platform to deubiquitinate PRP31 (show PRPF31 Antibodies) and PRP3 (show CLCA4 Antibodies)

  2. TGF-b promotes the translation of USP15 through activation of mammalian target of rapamycin (show FRAP1 Antibodies) by the phosphoinositide 3-kinase/AKT (show AKT1 Antibodies) pathway. Upregulation of USP15 translation links the crosstalk between TGF-beta (show TGFB1 Antibodies) signaling and p53 (show TP53 Antibodies) stability, allowing this cytokine to have a critical role in cancer progression.

  3. We concluded that USP15 attenuates IGF-I (show IGF1 Antibodies) signaling by antagonizing Nedd4 (show NEDD4 Antibodies)-induced IRS-2 (show IRS2 Antibodies) ubiquitination.

  4. These results uncover a new regulatory mechanism that USP15 activates Nrf1 (show NFE2L1 Antibodies) against the beta-TrCP (show BTRC Antibodies) inhibition to maintain proteostasis.

  5. Study identified USP15 as having recurrent de novo loss of function mutations and discovered evidence supporting two other known genes with recurrent de novo variants (FOXP1 (show FOXP1 Antibodies) and KDM5B (show KDM5B Antibodies)).

  6. crystal structures of SART3 (show SART3 Antibodies) in the apo (show C9orf3 Antibodies)-form and in complex with the DUSP (show DUSP5 Antibodies)-UBL domain of USP15 at 2.0 and 3.0 A, respectively. Structural analysis reveals SART3 (show SART3 Antibodies) contains 12 half-a-tetratricopeptide (HAT (show MGEA5 Antibodies)) repeats, organized into two subdomains, HAT (show MGEA5 Antibodies)-N and HAT (show MGEA5 Antibodies)-C. SART3 (show SART3 Antibodies) dimerizes through the concave surface of HAT (show MGEA5 Antibodies)-C, whereas the HAT (show MGEA5 Antibodies)-C convex surface binds USP15 in a novel bipartite mode.

  7. SMURF2 (show SMURF2 Antibodies) is a critical target of USP15 in the TGF-beta (show TGFB1 Antibodies) signaling pathway.

  8. our data demonstrate that USP15 acts as a negative regulator of RIG-I (show DDX58 Antibodies) signaling via DUB-dependent and independent mechanisms.

  9. These data identify USP15 as an antagonist of Parkin (show PARK2 Antibodies) and suggest that USP15 inhibition could be a therapeutic strategy for PD cases caused by reduced Parkin (show PARK2 Antibodies) levels.

  10. Data show that USP15 enhances BMP-induced phosphorylation of SMAD1 (show GARS Antibodies) by interacting with and deubiquitylating ALK3 (show BMPR1A Antibodies).

Mouse (Murine) Ubiquitin Specific Peptidase 15 (USP15) interaction partners

  1. In hematopoietic cells and in resident brain cells, USP15 was coexpressed with, and functionally acted together with the E3 ubiquitin ligase (show MUL1 Antibodies) TRIM25 (show TRIM25 Antibodies) to positively regulate type I interferon (show IFNA Antibodies) responses and to promote pathogenesis during neuroinflammation.

  2. T cell intrinsic USP15 deficiency causes excessive production of IFN-gamma (show IFNG Antibodies), which promotes an immunosuppressive tumor microenvironment during MCA (show RSPH1 Antibodies)-induced primary tumorigenesis.

  3. Both mouse and human have 22 exons with identical splice sites and an exon/intron structure identical to the mouse Usp4 (show USP4 Antibodies) gene.

USP15 Antigen Profile

Protein Summary

This gene encodes a member of the ubiquitin specific protease (USP) family of deubiquitinating enzymes. USP enzymes play critical roles in ubiquitin-dependent processes through polyubiquitin chain disassembly and hydrolysis of ubiquitin-substrate bonds. The encoded protein associates with the COP9 signalosome, and also plays a role in transforming growth factor beta signalling through deubiquitination of receptor-activated SMAD transcription factors. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 2.

Gene names and symbols associated with USP15

  • ubiquitin specific peptidase 15 (USP15) antibody
  • universal stress protein (usp15) antibody
  • ubiquitin specific peptidase 15 (usp15) antibody
  • ubiquitin specific peptidase 15 (LOC100224751) antibody
  • ubiquitin specific peptidase 15 (Usp15) antibody
  • 4921514G19Rik antibody
  • AI327321 antibody
  • E430033I05Rik antibody
  • Gcap18 antibody
  • mKIAA0529 antibody
  • Ubp109 antibody
  • UNP antibody
  • UNPH-2 antibody
  • UNPH4 antibody
  • USP15 antibody

Protein level used designations for USP15

ubiquitin specific peptidase 15 , universal stress protein , ubiquitin carboxyl-terminal hydrolase 15-like , ubiquitin carboxyl-terminal hydrolase 15 , ubiquitin specific protease 15 , ubiquitous nuclear protein , Deubiquitinating enzyme 15 , Ubiquitin thioesterase 15 , Ubiquitin-specific-processing protease 15 , deubiquitinating enzyme 15 , ubiquitin thioesterase 15 , ubiquitin-specific-processing protease 15 , ubiquitin thiolesterase 15 , granule cell antiserum positive 18 , deubiquitinating enzyme Ubp109 , ubiquitin carboxyl-terminal hydrolase of 109 kDa

GENE ID SPECIES
716793 Macaca mulatta
3128959 Haloarcula marismortui ATCC 43049
100090554 Ornithorhynchus anatinus
100464241 Ailuropoda melanoleuca
395644 Gallus gallus
452035 Pan troglodytes
100012616 Monodelphis domestica
100055857 Equus caballus
100158604 Xenopus (Silurana) tropicalis
100224751 Taeniopygia guttata
100356438 Oryctolagus cuniculus
100412030 Callithrix jacchus
100454837 Pongo abelii
100542201 Meleagris gallopavo
100554748 Anolis carolinensis
100586852 Nomascus leucogenys
538284 Bos taurus
9958 Homo sapiens
14479 Mus musculus
474424 Canis lupus familiaris
100524085 Sus scrofa
171329 Rattus norvegicus
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