Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Additionally we are shipping USP22 Antibodies (87) and many more products for this protein.
Showing 3 out of 3 products:
Loss of Ataxin-7 results in a toxic gain of activity of the Non-stop deubiquitinase.
Data establish that Nonstop actually functions as an ubiquitin (show UBA52 Proteins) protease to control the levels of ubiquitinated histone H2B in flies. We further establish that Nonstop is the functional homolog of yeast Ubp8
3 additional subunits of TFTC/STAGA (dSgf11, non-stop, & en(y)2) help form the deubiquitination module. This module is an enhancer of position effect variegation in Drosophila.
we demonstrated that USP22 was highly expressed in OS tissues and cells lines. Downregulation of USP22 inhibited OS cell proliferation, invasion, and EMT (show ITK Proteins) in vitro. In addition, downregulation of USP22 suppressed OS tumor growth and metastasis in vivo.
In breast cancer cell lines USP22 increases c-Myc (show MYC Proteins) stability through c-Myc (show MYC Proteins) deubiquitination, which is closely correlated with breast cancer progression.
that nuclear GSK3beta- and USP22-mediated KDM1A (show KDM1A Proteins) stabilization is essential for glioblastoma tumorigenesis
findings suggest that USP22 may be involved in hepatocellular carcinoma progression in cooperation with survivin (show BIRC5 Proteins).
These findings provide evidence that high USP22 expression might be important in tumor progression and serves as an independent molecular marker for poor hepatocellular carcinoma prognosis
USP22 attenuated the invasion capacity of colon cancer cells by inhibiting the STAT3 (show STAT3 Proteins)/MMP9 (show MMP9 Proteins) signaling pathway.
Our data indicated that USP22 may promote lung adenocarcinoma cell invasion by the induction of EMT (show ITK Proteins).
Data show that the aggregates formed by polyQ-expanded ataxin 7 sequester ubiquitin-specific protease (USP22) through specific interactions.
the deubiquitinating enzyme activity of USP22 is necessary for regulating HeLa cell growth, and it promotes cell proliferation via the c-Myc (show MYC Proteins)/cyclin D2 (show CCND2 Proteins), BMI-1 (show BMI1 Proteins) and p53 (show TP53 Proteins) pathways in HeLa cells
ShRNA-mediated silencing of the ubiquitin-specific protease 22 gene restrained cell progression and affected the Akt (show AKT1 Proteins) pathway in nasopharyngeal carcinoma.
high D-glucose induces increased expression of USP22 in cultured podocytes and diabetic rats. USP22 inhibition confers a protective effect against high glucose-induced podocyte depletion, apoptosis and inflammation.
Usp22 deficiency impairs intestinal epithelial lineage specification.
USP22 is a transcriptional repressor of the locus encoding the core pluripotency factor sex-determining region Y-box 2 (SOX2 (show SOX2 Proteins)) in embryonic stem cells.
Genetic deletion of the usp22 gene results in Sirt1 (show SIRT1 Proteins) instability, elevated p53 (show TP53 Proteins) transcriptional activity and early embryonic lethality.
Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators, where it is required for transcription (By similarity).
ubiquitin specific peptidase 22
, ubiquitin thiolesterase 22
, ubiquitin carboxyl-terminal hydrolase 22-like
, ubiquitin specific protease 22
, universal stress protein
, deubiquitinating enzyme 22
, ubiquitin carboxyl-terminal hydrolase 22
, ubiquitin thioesterase 22
, ubiquitin-specific processing protease 22
, ubiquitin-specific-processing protease 22