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The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Additionally we are shipping Ubiquitin-Like Modifier Activating Enzyme 7 Proteins (8) and Ubiquitin-Like Modifier Activating Enzyme 7 Kits (5) and many more products for this protein.
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Human Monoclonal UBA7 Primary Antibody for ELISA, WB - ABIN967228
Carritt, Kok, van den Berg, Osinga, Pilz, Hofstra, Davis, van der Veen, Rabbitts, Gulati: A gene from human chromosome region 3p21 with reduced expression in small cell lung cancer. in Cancer research 1992
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Human Monoclonal UBA7 Primary Antibody for ELISA, WB - ABIN969450
Kok, Hofstra, Pilz, van den Berg, Terpstra, Buys, Carritt: A gene in the chromosomal region 3p21 with greatly reduced expression in lung cancer is similar to the gene for ubiquitin-activating enzyme. in Proceedings of the National Academy of Sciences of the United States of America 1993
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the cellular effects of progerin expression in Hutchinson-Gilford progeria syndrome are transduced, at least in part, through reduced function of the Ran GTPase (show RAN Antibodies) and E2 SUMOylation pathways.
UBE1L is a retinoid target that triggers PML (show PML Antibodies)/RARalpha (show RARA Antibodies) degradation and apoptosis in acute promyelocytic leukemia (show PML Antibodies)
RA treatment of APL (show FASL Antibodies) and other RA-responsive leukemic cells induced expression of UBE1L and ISG15 (show ISG15 Antibodies) as well as intracellular ISG15 (show ISG15 Antibodies) conjugates. A physical association was found between UBE1L and ISG15 (show ISG15 Antibodies) in vivo.
Ube1L was required for transfer of ISG15 (show ISG15 Antibodies) to UbcH8 (show UBE2E2 Antibodies) and for binding of Ube1L to UbcH8 (show UBE2E2 Antibodies)
UBE1L-ISG15 (show ISG15 Antibodies) preferentially inhibits cyclin D1 (show CCND1 Antibodies) in lung cancer
Inhibitor-sensitive tyrosine kinase (show TYRO3 Antibodies) controls the population heterogeneity of basal STAT1 (show STAT1 Antibodies) activity in Ube1l deficient fibroblasts.
Bone marrow transplantation experiment revealed a 50% reduction in repopulation potential of Ube1L-deficient cells at 3weeks posttransplantation, but no differences at 6 and 12weeks.
UBE1L and protein ISGylation are not critical for IFN-alpha (show IFNA Antibodies)/beta signaling via JAK (show JAK3 Antibodies)/STAT (show STAT1 Antibodies) activation.
Ube1l is not a tumor suppressor gene in K-ras(LA2) lung cancer mouse model.
Both UbE1L(-/-) and ISG15 (show ISG15 Antibodies)(-/-) mice display increased susceptibility to influenza B virus infection, including non-mouse-adapted strains.
The importance of UbE1L was confirmed by demonstrating that mice lacking this ISG15 (show ISG15 Antibodies) E1 enzyme (show ENOPH1 Antibodies) were highly susceptible to Sindbis virus infection.
ISG15 (show ISG15 Antibodies), UBE1l and UBCH8 (show UBE2E2 Antibodies) genes are significantly upregulated in the artificially inseminated pregnant cows.
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein.
UBA1, ubiquitin-activating enzyme E1 homolog B
, UBA7, ubiquitin-activating enzyme E1
, ubiquitin-activating enzyme 7
, ubiquitin-activating enzyme E1 homolog
, ubiquitin-activating enzyme E1-related protein
, ubiquitin-activating enzyme-2
, ubiquitin-like modifier-activating enzyme 7
, ubiquitin-activating enzyme E1 (A1S9T and BN75 temperature sensitivity complementing)
, ubiquitin-conjugating enzyme E2R 2
, ubiquitin conjugating enzyme E2
, ubiquitin-like modifier activating enzyme 7
, ubiquitin-like modifier-activating enzyme 7-like