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VAMP (Vesicle-Associated Membrane Protein)-Associated Protein B and C Proteins (VAPB)

The protein encoded by VAPB is a type IV membrane protein found in plasma and intracellular vesicle membranes. Additionally we are shipping VAPB Antibodies (75) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
VAPB 9217 O95292
Rat VAPB VAPB 60431 Q9Z269
Mouse VAPB VAPB 56491  
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Top VAPB Proteins at antibodies-online.com

Showing 7 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 2 to 3 Days
$253.00
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$364.64
Details

VAPB Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,

Top referenced VAPB Proteins

  1. Human VAPB Protein expressed in Escherichia coli (E. coli) - ABIN2181890 : Fujimoto, Hamamoto, Taniguchi, Chikahira, Okabe: Molecular epidemiology of adenovirus type 3 detected from 1994 to 2006 in Hyogo Prefecture, Japan. in Japanese journal of infectious diseases 2008 (PubMed)
    Show all 4 references for ABIN2181890

  2. Human VAPB Protein expressed in Escherichia coli (E. coli) - ABIN2003347 : Choudhary, Kumar, Gnad, Nielsen, Rehman, Walther, Olsen, Mann: Lysine acetylation targets protein complexes and co-regulates major cellular functions. in Science (New York, N.Y.) 2009 (PubMed)
    Show all 4 references for ABIN2003347

  3. Human VAPB Protein expressed in Escherichia coli (E. coli) - ABIN667277 : Nishimura, Mitne-Neto, Silva, Richieri-Costa, Middleton, Cascio, Kok, Oliveira, Gillingwater, Webb, Skehel, Zatz: A mutation in the vesicle-trafficking protein VAPB causes late-onset spinal muscular atrophy and amyotrophic lateral sclerosis. in American journal of human genetics 2004 (PubMed)
    Show all 2 references for ABIN667277

More Proteins for VAMP (Vesicle-Associated Membrane Protein)-Associated Protein B and C (VAPB) Interaction Partners

Human VAMP (Vesicle-Associated Membrane Protein)-Associated Protein B and C (VAPB) interaction partners

  1. Our work revealed that VAP-A/B knockdown impaired the processing and secretion of PAUF, which is one of the cargo proteins of carriers of the trans-Golgi network to the cell surface.

  2. Heterozygous P56S Vapb knock-in mice show mild age-dependent defects in motor behaviors as characteristic features of the disease. The homozygous P56S Vapb knock-in mice show more severe defects compared with heterozygous mice reflecting the dominant and dose-dependent effects of P56S mutation.

  3. VAPB inhibited the degradation of DeltaF508-CFTR in the ER through interactions with the RMA1-Derlin-BAP31-VCP pathway.

  4. Study characterizes the human VAPB-HCV NS5B interaction and reveals that NS5B C-linker is intrinsically disordered in solution but capable of binding the human VAPB-MSP (show MSMB Proteins) domain which overlaps with those for binding HCV NS5A and human Eph (show EPHA1 Proteins) receptors.

  5. The VAPB and its interacting partners cooperatively regulate protein trafficking through the ERGIC by modulating PtdIns4P levels.

  6. results suggest that the binding of vesicle-associated membrane protein-associated protein B(VAP-B) to Rab3 GTPase activating protein 1(RAB3GAP1 (show RAB3GAP1 Proteins)) is implicated in the regulation of nuclear envelope formation through ER-Golgi intermediate compartment

  7. P56S-VAPB was found to suppress adipocyte differentiation by promoting the activation of the ATF4 (show ATF4 Proteins)-CHOP (show DDIT3 Proteins) pathway

  8. The repertoire of VAPB interactors is more diverse than previously anticipated and link VAPB to the function of ATPase complexes such as p97 (show EIF4G2 Proteins)/FAF1 (show FAF1 Proteins) and ASNA1 (show ASNA1 Proteins)/transmembrane-domain recognition complex.

  9. In patients with familial or sporadic amyotrophic lateral sclerosis (ALS (show IGFALS Proteins)) from Portugal, Iceland and Sweden no association is found with disease and VAMP-associated protein type B (VAPB) mutations.

  10. Findings provide new pathophysiological mechanisms of P56S VAPB that differentially affect the function and survival of corticospinal and spinal motor neurons in familial amyotrophic lateral sclerosis 8.

Mouse (Murine) VAMP (Vesicle-Associated Membrane Protein)-Associated Protein B and C (VAPB) interaction partners

  1. To identify pathological defects in animals expressing the P56S mutant VAPB protein at physiological levels in the appropriate tissues, we have generated Vapb knock-in mice

  2. The disruption of the IRE1 (show ERN1 Proteins)-XBP1 (show XBP1 Proteins) pathway is a cause for the reduced myotube formation in P56S-VAPB-mutation expressing cells.

  3. Vapb knock-out mice exhibit abnormal muscular triacylglycerol levels and FoxO (show FOXO3 Proteins) target gene transcriptional responses to fasting and refeeding

  4. Mice knocked-out for Vapb showed mild motor deficits after 18 months of age.

  5. VapB positively regulates RANKL (show TNFSF11 Proteins)-mediated osteoclastogenesis via PLCgamma2 (show PLCG2 Proteins)-Ca(2 (show CA2 Proteins)+)-NFAT (show NFATC1 Proteins) signaling

  6. Co-expression of mutant protein-associated protein B (show LEPREL2 Proteins) (VAPB) enhances the transactive response DNA-binding protein (show HSF4 Proteins)-43 (TDP-43 (show TARDBP Proteins))-induced motor neuronal cell death while that of wild type-VAPB attenuates it.

  7. Adeno (show ADORA2A Proteins)-associated viral-mediated over-expression of both wild-type and mutated form of human VAPB selectively induces death of primary motor neurons, albeit with different kinetics.

  8. However, VAPBP56S but not VAPBwt transgenic mice develop cytoplasmic TDP-43 (show TARDBP Proteins) accumulations within spinal cord motor neurons that were first detected at 18 months of age.

  9. The total loss of VAPB function in unfolded protein response, induced by one P56S mutant allele, may contribute to the development of P56SVAPB- induced amyotrophic lateral sclerosis.

VAPB Protein Profile

Protein Summary

The protein encoded by this gene is a type IV membrane protein found in plasma and intracellular vesicle membranes. The encoded protein is found as a homodimer and as a heterodimer with VAPA. This protein also can interact with VAMP1 and VAMP2 and may be involved in vesicle trafficking.

Gene names and symbols associated with VAPB

  • vesicle-associated membrane protein-associated protein B/C (Tsp_07972)
  • VAMP (vesicle-associated membrane protein)-associated protein B and C (VAPB)
  • VAMP-associated protein B/C (LOC788595)
  • VAMP-associated protein B/C (LOC100350714)
  • VAMP (vesicle-associated membrane protein)-associated protein B and C (Vapb)
  • vesicle-associated membrane protein, associated protein B and C (Vapb)
  • AI225786 protein
  • AI840687 protein
  • AI848259 protein
  • ALS8 protein
  • D2Abb2e protein
  • R75548 protein
  • VAMP-B protein
  • Vamp33b protein
  • VAP-B protein
  • VAP33b protein

Protein level used designations for VAPB

vesicle-associated membrane protein-associated protein B/C , VAMP (vesicle-associated membrane protein)-associated protein B and C , VAMP-associated protein B/C , VAMP-associated 33 kDa protein , VAMP-B , VAMP-associated protein B , VAP-B , vesicle-associated membrane protein-associated protein B , vesicle-associated membrane protein, associated protein B and C , VAMP-associated protein 33b

GENE ID SPECIES
10906529 Trichinella spiralis
469984 Pan troglodytes
788595 Bos taurus
100350714 Oryctolagus cuniculus
9217 Homo sapiens
419317 Gallus gallus
100144536 Sus scrofa
326580 Bos taurus
60431 Rattus norvegicus
56491 Mus musculus
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