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The protein encoded by VAPB is a type IV membrane protein found in plasma and intracellular vesicle membranes. Additionally we are shipping VAPB Antibodies (75) and many more products for this protein.
Showing 7 out of 12 products:
Human VAPB Protein expressed in Escherichia coli (E. coli) - ABIN2181890
Fujimoto, Hamamoto, Taniguchi, Chikahira, Okabe: Molecular epidemiology of adenovirus type 3 detected from 1994 to 2006 in Hyogo Prefecture, Japan. in Japanese journal of infectious diseases 2008
Show all 4 references for ABIN2181890
Human VAPB Protein expressed in Escherichia coli (E. coli) - ABIN2003347
Choudhary, Kumar, Gnad, Nielsen, Rehman, Walther, Olsen, Mann: Lysine acetylation targets protein complexes and co-regulates major cellular functions. in Science (New York, N.Y.) 2009
Show all 4 references for ABIN2003347
Human VAPB Protein expressed in Escherichia coli (E. coli) - ABIN667277
Nishimura, Mitne-Neto, Silva, Richieri-Costa, Middleton, Cascio, Kok, Oliveira, Gillingwater, Webb, Skehel, Zatz: A mutation in the vesicle-trafficking protein VAPB causes late-onset spinal muscular atrophy and amyotrophic lateral sclerosis. in American journal of human genetics 2004
Show all 2 references for ABIN667277
Our work revealed that VAP-A/B knockdown impaired the processing and secretion of PAUF, which is one of the cargo proteins of carriers of the trans-Golgi network to the cell surface.
Heterozygous P56S Vapb knock-in mice show mild age-dependent defects in motor behaviors as characteristic features of the disease. The homozygous P56S Vapb knock-in mice show more severe defects compared with heterozygous mice reflecting the dominant and dose-dependent effects of P56S mutation.
VAPB inhibited the degradation of DeltaF508-CFTR in the ER through interactions with the RMA1-Derlin-BAP31-VCP pathway.
Study characterizes the human VAPB-HCV NS5B interaction and reveals that NS5B C-linker is intrinsically disordered in solution but capable of binding the human VAPB-MSP (show MSMB Proteins) domain which overlaps with those for binding HCV NS5A and human Eph (show EPHA1 Proteins) receptors.
The VAPB and its interacting partners cooperatively regulate protein trafficking through the ERGIC by modulating PtdIns4P levels.
results suggest that the binding of vesicle-associated membrane protein-associated protein B(VAP-B) to Rab3 GTPase activating protein 1(RAB3GAP1 (show RAB3GAP1 Proteins)) is implicated in the regulation of nuclear envelope formation through ER-Golgi intermediate compartment
P56S-VAPB was found to suppress adipocyte differentiation by promoting the activation of the ATF4 (show ATF4 Proteins)-CHOP (show DDIT3 Proteins) pathway
The repertoire of VAPB interactors is more diverse than previously anticipated and link VAPB to the function of ATPase complexes such as p97 (show EIF4G2 Proteins)/FAF1 (show FAF1 Proteins) and ASNA1 (show ASNA1 Proteins)/transmembrane-domain recognition complex.
In patients with familial or sporadic amyotrophic lateral sclerosis (ALS (show IGFALS Proteins)) from Portugal, Iceland and Sweden no association is found with disease and VAMP-associated protein type B (VAPB) mutations.
Findings provide new pathophysiological mechanisms of P56S VAPB that differentially affect the function and survival of corticospinal and spinal motor neurons in familial amyotrophic lateral sclerosis 8.
To identify pathological defects in animals expressing the P56S mutant VAPB protein at physiological levels in the appropriate tissues, we have generated Vapb knock-in mice
The disruption of the IRE1 (show ERN1 Proteins)-XBP1 (show XBP1 Proteins) pathway is a cause for the reduced myotube formation in P56S-VAPB-mutation expressing cells.
Vapb knock-out mice exhibit abnormal muscular triacylglycerol levels and FoxO (show FOXO3 Proteins) target gene transcriptional responses to fasting and refeeding
Mice knocked-out for Vapb showed mild motor deficits after 18 months of age.
VapB positively regulates RANKL (show TNFSF11 Proteins)-mediated osteoclastogenesis via PLCgamma2 (show PLCG2 Proteins)-Ca(2 (show CA2 Proteins)+)-NFAT (show NFATC1 Proteins) signaling
Co-expression of mutant protein-associated protein B (show LEPREL2 Proteins) (VAPB) enhances the transactive response DNA-binding protein (show HSF4 Proteins)-43 (TDP-43 (show TARDBP Proteins))-induced motor neuronal cell death while that of wild type-VAPB attenuates it.
Adeno (show ADORA2A Proteins)-associated viral-mediated over-expression of both wild-type and mutated form of human VAPB selectively induces death of primary motor neurons, albeit with different kinetics.
However, VAPBP56S but not VAPBwt transgenic mice develop cytoplasmic TDP-43 (show TARDBP Proteins) accumulations within spinal cord motor neurons that were first detected at 18 months of age.
The total loss of VAPB function in unfolded protein response, induced by one P56S mutant allele, may contribute to the development of P56SVAPB- induced amyotrophic lateral sclerosis.
The protein encoded by this gene is a type IV membrane protein found in plasma and intracellular vesicle membranes. The encoded protein is found as a homodimer and as a heterodimer with VAPA. This protein also can interact with VAMP1 and VAMP2 and may be involved in vesicle trafficking.
vesicle-associated membrane protein-associated protein B/C
, VAMP (vesicle-associated membrane protein)-associated protein B and C
, VAMP-associated protein B/C
, VAMP-associated 33 kDa protein
, VAMP-associated protein B
, vesicle-associated membrane protein-associated protein B
, vesicle-associated membrane protein, associated protein B and C
, VAMP-associated protein 33b