WW Domain Containing E3 Ubiquitin Protein Ligase 1 Proteins (WWP1)

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Additionally we are shipping WWP1 Antibodies (28) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
WWP1 11059 Q9H0M0
Mouse WWP1 WWP1 107568 Q8BZZ3
Rat WWP1 WWP1 297930  
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Top WWP1 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$11,073.30
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
HOST_Baculovirus infected Insect Cells Human GST tag   50 μg Log in to see 10 to 12 Days
$570.24
Details

WWP1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,

More Proteins for WW Domain Containing E3 Ubiquitin Protein Ligase 1 (WWP1) Interaction Partners

Human WW Domain Containing E3 Ubiquitin Protein Ligase 1 (WWP1) interaction partners

  1. Knock-down of WWP1 abrogates DNA damage-induced down-regulation of DeltaNp63alphaand partially rescues cell apoptosis

  2. Describe an autoinhibitory mechanism for WWP1 ubiquitin ligase involving a linker-HECT domain interaction. This intramolecular interaction traps the HECT enzyme in its inactive state and can be relieved by linker phosphorylation.

  3. results demonstrate that WWP1 catalyzes the formation of Ub chains through a sequential addition mechanism, in which Ub monomers are transferred in a successive fashion to the substrate, and that ubiquitination by WWP1 requires the presence of a low-affinity, noncovalent Ub-binding site within the HECT domain.

  4. Study shows that WWP1 was upregulated in prostate cancer (PCa (show FLVCR1 Proteins)) clinical specimens and contributed to cancer cell invasion, indicating that this target of Mir (show MLXIP Proteins)-452 functioned as an oncogene (show RAB1A Proteins).

  5. Overexpression of WWP1 promotes tumorigenesis in patients with hepatocellular carcinoma.

  6. PTPN14 (show PTPN14 Proteins), a Pez (show PTPN14 Proteins) mammalian homolog, is degraded by overexpressed Su(dx) or Su(dx) homologue WWP1 in mammalian cells.

  7. miR (show MLXIP Proteins)-21 overexpression or WWP1 knockdown in endothelial progenitor cells significantly activates the TGFbeta (show TGFB1 Proteins) signaling pathway and inhibits cell proliferation.

  8. The cancer-driven alteration of WWP1 culminates in excessive TbetaRI (show TGFBR1 Proteins) degradation and attenuated TGFbeta1 (show TGFB1 Proteins) cytostatic signaling, a consequence that could conceivably confer tumorigenic properties to WWP1.

  9. Results suggest that elevated transcription and expression levels of ubiquitin ligase E3s WWP1, Smurf1 (show SMURF1 Proteins) and Smurf2 (show SMURF2 Proteins) genes may be the mechanisms of occurrence, development and metastasis of prostate cancer.

  10. Most notably, WWP1 downregulation both inactivated PTEN-Akt (show AKT1 Proteins) signaling pathway in MKN-45 and AGS (show JAG1 Proteins) cells. our findings suggest that WWP1 acts as an oncogenic factor and should be considered as a novel interfering molecular target for gastric carcinoma

Mouse (Murine) WW Domain Containing E3 Ubiquitin Protein Ligase 1 (WWP1) interaction partners

  1. Atypical ubiquitination by E3 ligase WWP1 inhibits the proteasome-mediated degradation of mutant huntingtin (show HTT Proteins). This suggests that the E3 ligase WWP1 is involved in the pathogenesis of Huntington's disease; therefore, it may be a novel target for therapeutic intervention.

  2. Cardiomyocyte-specific overexpression of Wwp1 contributes to reduction in Connexin 43 (show GJA1 Proteins) and arrhythmogenesis.

  3. Wwp1 negatively regulates osteoblast functions.

  4. WWP1 functions as an E3 ligase when cells are stimulated with LPS (show TLR4 Proteins) by binding to TRAF6 (show TRAF6 Proteins) and promoting K48-linked polyubiquitination. This results in the proteasomal degradation of TRAF6 (show TRAF6 Proteins)

  5. WWP1 down-regulates AMPKalpha2 under high glucose culture conditions via the ubiquitin-proteasome pathway

  6. Wwp1 promotes ubiquitination and degradation of JunB (show JUNB Proteins), an AP-1 (show JUN Proteins) transcription factor that positively regulates osteoblast differentiation.

WWP1 Protein Profile

Protein Summary

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1\; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF.

Gene names and symbols associated with WWP1

  • SMAD specific E3 ubiquitin protein ligase 1 (smurf1)
  • WW domain containing E3 ubiquitin protein ligase 1 (WWP1)
  • WW domain containing E3 ubiquitin protein ligase 1 (wwp1)
  • WW domain containing E3 ubiquitin protein ligase 1 (Wwp1)
  • 8030445B08Rik protein
  • AIP5 protein
  • hSDRP1 protein
  • SDRP1 protein
  • Tiul1 protein
  • wu:fb30b12 protein
  • WWP1 protein
  • zgc:66401 protein

Protein level used designations for WWP1

E3 ubiquitin ligase SMURF1 , E3 ubiquitin-protein ligase SMURF1 , WW domain containing E3 ubiquitin protein ligase 1 , smad ubiquitination regulatory factor 1 , WW domain-containing protein 1 , NEDD4-like E3 ubiquitin-protein ligase WWP1 , Nedd-4-like ubiquitin-protein ligase , TGIF-interacting ubiquitin ligase 1 , atrophin-1 interacting protein 5 , atrophin-1-interacting protein 5

GENE ID SPECIES
321695 Danio rerio
464269 Pan troglodytes
100038255 Xenopus (Silurana) tropicalis
100157283 Sus scrofa
420212 Gallus gallus
11059 Homo sapiens
477930 Canis lupus familiaris
513789 Bos taurus
107568 Mus musculus
297930 Rattus norvegicus
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