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Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmarks for the intron exon structure of genes and directs post- transcriptional . Additionally we are shipping Within Bgcn Homolog (Drosophila) Proteins (17) and many more products for this protein.
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Human Polyclonal WIBG Primary Antibody for EIA, IHC (p) - ABIN955577
Diem, Chan, Younis, Dreyfuss: PYM binds the cytoplasmic exon-junction complex and ribosomes to enhance translation of spliced mRNAs. in Nature structural & molecular biology 2007
Show all 4 references for ABIN955577
Human Polyclonal WIBG Primary Antibody for IHC (p), WB - ABIN654666
Gehring, Lamprinaki, Kulozik, Hentze: Disassembly of exon junction complexes by PYM. in Cell 2009
suggest that PYM functions as a bridge between EJC-bearing spliced mRNAs and the translation machinery to enhance translation of the mRNAs
PYM is an Exon junction complexes(EJC) disassembly factor that acts both in vitro and in living cells, and that antagonizes important EJC functions.
Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmarks for the intron exon structure of genes and directs post- transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as a EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions (By similarity).
, undefined 3
, Protein wibg homolog
, partner of Y14 and mago
, protein wibg homolog