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anthrax Toxin Receptor 1 (ANTXR1) ELISA Kits

ANTXR1 encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. Additionally we are shipping anthrax Toxin Receptor 1 Antibodies (148) and anthrax Toxin Receptor 1 Proteins (13) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
ANTXR1 84168 Q9H6X2
ANTXR1 69538 Q9CZ52
ANTXR1 362393 Q0PMD2
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Top anthrax Toxin Receptor 1 ELISA Kits at antibodies-online.com

Showing 4 out of 7 products:

Catalog No. Reactivity Sensitivity Range Quantity Supplier Delivery Price Details
Human 15.6 pg/ml 62.5-4000 pg/mL 96 Tests Log in to see 11 to 13 Days
$910.56
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Rat
96 Tests Log in to see 11 to 13 Days
$875.60
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Mouse
96 Tests Log in to see 11 to 13 Days
$875.60
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Monkey
96 Tests Log in to see 16 to 21 Days
$999.43
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More ELISA Kits for anthrax Toxin Receptor 1 Interaction Partners

Human anthrax Toxin Receptor 1 (ANTXR1) interaction partners

  1. In the absence of any N-linked glycans, TEM8 fails to fold correctly and is recognized by the ER quality control machinery.

  2. These studies expand the allelic spectrum in this rare condition and potentially provide insight into the role of ANTXR1 in the regulation of the extracellular matrix.

  3. ANTXR2 (show ANTXR2 ELISA Kits) is expressed by human uterine smooth muscle cell and appears important for normal human uterine smooth muscle cell viability, migration and contractility.

  4. High ANTXR1 accelerates breast tumor growth and lung metastasis.

  5. There is an attenuation of ANTXR1 expression post-infection which may be a protective mechanism that has evolved to prevent reinfection.

  6. Mutations affecting ANTXR1 function are responsible for GAPO syndrome's characteristic generalized defect in extracellular-matrix homeostasis.

  7. An acidic region in the cytosolic tail of ANTXR1 decreases actin association, sending a signal that prevents binding of ANTXR1 to the protective antigen and providing evidence that cytoskeletal dynamics regulate ANTXR1 function.

  8. Disruption of Tem8 results in impaired growth of human tumor xenografts of diverse origin including melanoma, breast, colon, and lung cancer.

  9. The copy number of CEA (show CEACAM5 ELISA Kits) and TEM-8 mRNA, as detected by a real-time quantitative PCR, appears to be a promising marker for evaluating the risk of tumor spread.

  10. postulate that the developmentally controlled expression of TEM8 modulates endothelial cell response to canonical Wnt (show WNT2 ELISA Kits) signaling to regulate vessel patterning and density

Mouse (Murine) anthrax Toxin Receptor 1 (ANTXR1) interaction partners

  1. An essential physiologic role for Antxr1 in arteriogenesis and peripheral artery disease.

  2. Data demonstrate that TEM8 is an essential regulator of connective tissue homeostasis. it controls synthesis of major matrix components in both endothelial and fibroblastic cells and regulates signaling pathways and matrix degradation.

  3. These results strongly suggest that TEM8 is the only minor anthrax toxin receptor mediating direct lethality in vivo and that other proteins implicated as receptors do not play this role.

  4. This is the first demonstration that the ATR/TEM8 protein is highly expressed in epithelial cells, suggesting that the ATR/TEM8 expression pattern is highly relevant for understanding the pathogenesis of anthrax infection.

  5. The mRNA transcripts of both receptors, ANTXR1 and ANTXR2 (show ANTXR2 ELISA Kits) were detected in J774A.1 cells and mouse tissues suggesting that anthrax edema toxin and B. anthracis Sterne spore are involved in the ANTXR mRNA regulation in host cells.

  6. Data show that the lethality of anthrax toxin for mice is mostly mediated by CMG2 (show ANTXR2 ELISA Kits) and that TEM8 plays only a minor role.

  7. Host-derived TEM8 promotes the growth of certain tumors.

anthrax Toxin Receptor 1 (ANTXR1) Antigen Profile

Antigen Summary

This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described.

Gene names and symbols associated with ANTXR1

  • anthrax toxin receptor 1 (ANTXR1) antibody
  • anthrax toxin receptor 1 (LOC100357637) antibody
  • anthrax toxin receptor 1 (Antxr1) antibody
  • 2310008J16Rik antibody
  • 2810405N18Rik antibody
  • Antrx1 antibody
  • ANTXR1 antibody
  • ATR antibody
  • Tem8 antibody

Protein level used designations for ANTXR1

anthrax toxin receptor 1 , tumor endothelial marker 8 , anthrax toxin receptor 1-like , 2310008J16Rik , 2810405N18Rik

GENE ID SPECIES
470393 Pan troglodytes
612601 Canis lupus familiaris
100061334 Equus caballus
100357637 Oryctolagus cuniculus
100410030 Callithrix jacchus
100425392 Macaca mulatta
100513853 Sus scrofa
100598321 Nomascus leucogenys
84168 Homo sapiens
69538 Mus musculus
362393 Rattus norvegicus
616010 Bos taurus
428199 Gallus gallus
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