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anthrax Toxin Receptor 1 Proteins (ANTXR1)

ANTXR1 encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. Additionally we are shipping anthrax Toxin Receptor 1 Antibodies (171) and anthrax Toxin Receptor 1 Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ANTXR1 84168 Q9H6X2
ANTXR1 69538 Q9CZ52
ANTXR1 362393 Q0PMD2
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Top anthrax Toxin Receptor 1 Proteins at antibodies-online.com

Showing 8 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human Fc Tag 50 μg Log in to see 16 Days
$382.80
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,777.50
Details
HOST_Human Human His tag   10 μg Log in to see 5 Days
$154.00
Details

ANTXR1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, , ,
Mouse (Murine) ,
,
Rat (Rattus)

Top referenced anthrax Toxin Receptor 1 Proteins

  1. Human ANTXR1 Protein expressed in Human Cells - ABIN2005668 : Garlick, Batty, Mogridge: Binding of filamentous actin to anthrax toxin receptor 1 decreases its association with protective antigen. in Biochemistry 2012 (PubMed)
    Show all 2 references for ABIN2005668

More Proteins for anthrax Toxin Receptor 1 (ANTXR1) Interaction Partners

Human anthrax Toxin Receptor 1 (ANTXR1) interaction partners

  1. TEM8 may be differentially expressed between wound types and loss of this molecule impacts HaCaT growth and migration, potentially implicating this molecule as a factor involved in successful progression of wound healing.

  2. In the absence of any N-linked glycans, TEM8 fails to fold correctly and is recognized by the ER quality control machinery.

  3. These studies expand the allelic spectrum in this rare condition and potentially provide insight into the role of ANTXR1 in the regulation of the extracellular matrix.

  4. ANTXR2 (show ANTXR2 Proteins) is expressed by human uterine smooth muscle cell and appears important for normal human uterine smooth muscle cell viability, migration and contractility.

  5. High ANTXR1 accelerates breast tumor growth and lung metastasis.

  6. There is an attenuation of ANTXR1 expression post-infection which may be a protective mechanism that has evolved to prevent reinfection.

  7. Mutations affecting ANTXR1 function are responsible for GAPO syndrome's characteristic generalized defect in extracellular-matrix homeostasis.

  8. An acidic region in the cytosolic tail of ANTXR1 decreases actin association, sending a signal that prevents binding of ANTXR1 to the protective antigen and providing evidence that cytoskeletal dynamics regulate ANTXR1 function.

  9. Disruption of Tem8 results in impaired growth of human tumor xenografts of diverse origin including melanoma, breast, colon, and lung cancer.

  10. The copy number of CEA (show CEACAM5 Proteins) and TEM-8 mRNA, as detected by a real-time quantitative PCR, appears to be a promising marker for evaluating the risk of tumor spread.

Mouse (Murine) anthrax Toxin Receptor 1 (ANTXR1) interaction partners

  1. An essential physiologic role for Antxr1 in arteriogenesis and peripheral artery disease.

  2. Data demonstrate that TEM8 is an essential regulator of connective tissue homeostasis. it controls synthesis of major matrix components in both endothelial and fibroblastic cells and regulates signaling pathways and matrix degradation.

  3. These results strongly suggest that TEM8 is the only minor anthrax toxin receptor mediating direct lethality in vivo and that other proteins implicated as receptors do not play this role.

  4. This is the first demonstration that the ATR/TEM8 protein is highly expressed in epithelial cells, suggesting that the ATR/TEM8 expression pattern is highly relevant for understanding the pathogenesis of anthrax infection.

  5. The mRNA transcripts of both receptors, ANTXR1 and ANTXR2 (show ANTXR2 Proteins) were detected in J774A.1 cells and mouse tissues suggesting that anthrax edema toxin and B. anthracis Sterne spore are involved in the ANTXR mRNA regulation in host cells.

  6. Data show that the lethality of anthrax toxin for mice is mostly mediated by CMG2 (show ANTXR2 Proteins) and that TEM8 plays only a minor role.

  7. Host-derived TEM8 promotes the growth of certain tumors.

anthrax Toxin Receptor 1 (ANTXR1) Protein Profile

Protein Summary

This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described.

Gene names and symbols associated with ANTXR1

  • anthrax toxin receptor 1 (ANTXR1)
  • anthrax toxin receptor 1 (LOC100357637)
  • anthrax toxin receptor 1 (Antxr1)
  • 2310008J16Rik protein
  • 2810405N18Rik protein
  • Antrx1 protein
  • ANTXR1 protein
  • ATR protein
  • Tem8 protein

Protein level used designations for ANTXR1

anthrax toxin receptor 1 , tumor endothelial marker 8 , anthrax toxin receptor 1-like , 2310008J16Rik , 2810405N18Rik

GENE ID SPECIES
470393 Pan troglodytes
612601 Canis lupus familiaris
100061334 Equus caballus
100357637 Oryctolagus cuniculus
100410030 Callithrix jacchus
100425392 Macaca mulatta
100513853 Sus scrofa
100598321 Nomascus leucogenys
84168 Homo sapiens
69538 Mus musculus
362393 Rattus norvegicus
616010 Bos taurus
428199 Gallus gallus
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