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SHMT1 encodes the cellular form of serine hydroxymethyltransferase, a pyridoxal phosphate-containing enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. Additionally we are shipping serine Hydroxymethyltransferase 1 (Soluble) Proteins (13) and many more products for this protein.
Showing 10 out of 58 products:
Human Monoclonal SHMT1 Primary Antibody for WB - ABIN393802
Porter, Basu, Hubbard, Bates, Kalman, Rey, Smith, Smith, Steinmaus, Skibola: Association of genetic variation in cystathionine-beta-synthase and arsenic metabolism. in Environmental research 2010
Show all 5 references for ABIN393802
Human Polyclonal SHMT1 Primary Antibody for IHC (p), WB - ABIN658344
Summers, Mitchell, Stanislawska-Sachadyn, Baido, Blair, Von Feldt, Whitehead: Genetic and lifestyle variables associated with homocysteine concentrations and the distribution of folate derivatives in healthy premenopausal women. in Birth defects research. Part A, Clinical and molecular teratology 2010
Show all 4 references for ABIN658344
Arabidopsis thaliana Polyclonal SHMT1 Primary Antibody for WB - ABIN93560
Wei, Sun, Sandoval, Cross, Gordon, Kang, Roje: Folate polyglutamylation eliminates dependence of activity on enzyme concentration in mitochondrial serine hydroxymethyltransferases from Arabidopsis thaliana. in Archives of biochemistry and biophysics 2013
Show all 2 references for ABIN93560
Human Monoclonal SHMT1 Primary Antibody for IHC (p), ELISA - ABIN562870
Genovese, Gualandi, Taddia, Marverti, Pirondi, Marraccini, Perco, Pelà, Guerrini, Amoroso, Esposito, Martello, Ponterini, DArca, Costi: Mass spectrometric/bioinformatic identification of a protein subset that characterizes the cellular activity of anticancer peptides. in Journal of proteome research 2014
an association between MTRR (show MTRR Antibodies) 66 and SHMT1 1420 polymorphisms and spaceflight-induced vision changes
our meta-analysis suggested that the SHMT1 C1420T polymorphism was associated with decreased risk of breast cancer.
SHMT1 knockdown in lung cancer cells leads to cell cycle arrest and to p53 (show TP53 Antibodies)-dependent apoptosis.
In this meta-analysis, SHMT1 C1420T polymorphism did not have a significant association with the risk of cancer overall.
SHMT1 exists in solution as a tetramer, both in the absence and presence of PLP (show PLP1 Antibodies), while SHMT2 (show SHMT2 Antibodies) undergoes a dimer-to-tetramer transition.
found evidence for association of SHMT1 C1420T polymorphism with significantly reduced risk of breast cancer in Asians
SHMT1 C1420T polymorphism is not associated with overall cancer development.
serine hydroxymethyltransfarase C1420T reduces risk for both acute lymphoblastic leukemia and acute myeloid leukemia (show BCL11A Antibodies) and influences disease progression in acute lymphoblastic leukemia
SHMT1 C1420T and DNMT3B (show DNMT3B Antibodies) C46359T polymorphisms are not associated with HNC (show MMP8 Antibodies) development in Brazilian population, however, SHMT1 C1420T polymorphism is less frequent in patients with primary site of tumor in larynx
geography-specific effects of the SHMT1 polymorphism that render Europeans susceptible to colorectal caner, but not Americans.
Shmt1 and dietary folate deficiency influence metabolic markers of homocysteine remethylation in mice.
SHMT1 and TYMS (show TYMS Antibodies) localization to the nucleus is essential to prevent uracil accumulation in DNA
Data show that Shmt1 hemizygosity was associated with increased risk for intestinal cancer in Apc (show APC Antibodies)(min)(/+) mice through a gene-by-diet interaction.
These results provide evidence that disruption of Shmt1 expression causes NTDs by impairing thymidylate biosynthesis and shows that changes in the expression of genes that encode folate-dependent enzymes may be key determinates of NTD risk.
Shmt1 (SHMT1), but not Srr (show SRR Antibodies), is likely to be one of the genetic components regulating prepulse inhibition in mice and possibly relevant to human schizophrenia.
mitochondrial SHMT-derived one-carbon units are essential for folate-mediated one-carbon metabolism in the cytoplasm
SHMT1 and SHMT2 (show SHMT2 Antibodies) are functionally redundant in nuclear de novo thymidylate biosynthesis
we have expressed, characterized, and determined the crystal structures of rabbit cytosolic serine hydroxymethyltransferase T254A and T254C mutant forms, in the absence and presence of substrates.
SHM1 and SHM2 operate in a redundant manner in one-carbon metabolism of nonphotorespiring cells with a high demand of one-carbon units.
The senescence is initiated in shm1-1 under photorespiratory conditions. Transcription of the senescence marker SAG12 is enhanced in shm1-1.
Structural modeling of SHM1, SHM2, and SHM4 presented features that may explain the activity differences between the mitochondrial and cytosolic isozymes.
The characterization and expression of SHMT1 in A. thaliana. [SHMT1]
SHM1 expression is required for mitochondrial serine hydroxymethyltransferase (show SHMT2 Antibodies) activity and proper function of the C2 cycle during growth in ambient air.
SHMT1 interacts with GLU1 and this interaction is necessary for photorespiratory serine hydroxymethyltransferase (SHMT) activity.
This gene encodes the cellular form of serine hydroxymethyltransferase, a pyridoxal phosphate-containing enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one carbon units for synthesis of methionine, thymidylate, and purines in the cytoplasm. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative splicing of this gene results in 2 transcript variants encoding 2 different isoforms. Additional transcript variants have been described, but their biological validity has not been determined.
serine hydroxymethyltransferase, cytosolic
, serine hydroxymethyltransferase 1 (soluble)
, glycine hydroxymethyltransferase
, serine methylase
, cytoplasmic serine hydroxymethyltransferase
, cytosolic serine hydroxymethyltransferase
, serine hydroxymethyl transferase
, serine hydroxymethyltransferase 2 (mitochondrial)