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anti-serine Palmitoyltransferase, Long Chain Base Subunit 1 (SPTLC1) Antibodies

Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. Additionally we are shipping serine Palmitoyltransferase, Long Chain Base Subunit 1 Proteins (9) and serine Palmitoyltransferase, Long Chain Base Subunit 1 Kits (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SPTLC1 10558 O15269
SPTLC1 268656 O35704
SPTLC1 361213  
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Top anti-serine Palmitoyltransferase, Long Chain Base Subunit 1 Antibodies at antibodies-online.com

Showing 10 out of 106 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated IHC, WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Chicken Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of anti-SPTLC1 Antibody (C-term)(ABIN389109) in 293 cell line lysates (35 µg/lane).SPTLC1(arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (fro), WB 10 blots Log in to see 6 to 8 Days
$533.50
Details
Human Mouse Un-conjugated IF, WB Western blot analysis of LCB1 on a rat kidney lysate. Lane 1: 1:2500, lane 2: 1:5000, lane 3: 1:10,000 dilution of the Mouse Anti-LCB1 antibody. 50 μg Log in to see 5 to 6 Days
$205.42
Details
Human Rabbit Un-conjugated IHC (p), WB SPTLC1 was detected in paraffin-embedded sections of human intestinal cancer tissues using rabbit anti- SPTLC1 Antigen Affinity purified polyclonal antibody at 1 μg/mL. The immunohistochemical section was developed using SABC method Western blot analysis of SPTLC1 expression in rat brain extract (lane 1), mouse brain extract (lane 2) and MCF-7 whole cell lysates (lane 3). SPTLC1 at 53KD was detected using rabbit anti- SPTLC1 Antigen Affinity purified polyclonal antibody at0.5 μg/mL. The blot was developed using chemiluminescence (ECL) method 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of hSPTLC1-S41 (ABIN389108) in 293, Hela, K562 cell line and mouse liver tissue lysates (35 µg/lane). SPTLC1 (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB Anti-SPTLC1 antibody, IHC(P) IHC(P): Human Mammary Cancer Tissue 100 μg Log in to see 4 to 6 Days
$200.00
Details

SPTLC1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-serine Palmitoyltransferase, Long Chain Base Subunit 1 Antibodies

  1. Human Polyclonal SPTLC1 Primary Antibody for EIA, WB - ABIN357776 : Stachowitz, Alessandrini, Abeck, Ring, Behrendt: Permeability barrier disruption increases the level of serine palmitoyltransferase in human epidermis. in The Journal of investigative dermatology 2002 (PubMed)
    Show all 5 references for ABIN357776

  2. Human Polyclonal SPTLC1 Primary Antibody for EIA, WB - ABIN357775 : Nicholson, Dawkins, Blair, Auer-Grumbach, Brahmbhatt, Hulme: Hereditary sensory neuropathy type I: haplotype analysis shows founders in southern England and Europe. in American journal of human genetics 2001 (PubMed)
    Show all 5 references for ABIN357775

  3. Human Monoclonal SPTLC1 Primary Antibody for IF, WB - ABIN968462 : Hanada, Hara, Nishijima, Kuge, Dickson, Nagiec: A mammalian homolog of the yeast LCB1 encodes a component of serine palmitoyltransferase, the enzyme catalyzing the first step in sphingolipid synthesis. in The Journal of biological chemistry 1998 (PubMed)
    Show all 2 references for ABIN968462

  4. Human Polyclonal SPTLC1 Primary Antibody for IHC (fro), WB - ABIN265207 : He, Guan, Ong, Farooqui, Wenk: Expression, activity, and role of serine palmitoyltransferase in the rat hippocampus after kainate injury. in Journal of neuroscience research 2007 (PubMed)

  5. Human Polyclonal SPTLC1 Primary Antibody for WB - ABIN389109 : Wei, Yerokun, Leipelt, Haynes, Radhakrishna, Momin, Kelly, Park, Wang, Carton, Uhlinger, Merrill: Serine palmitoyltransferase subunit 1 is present in the endoplasmic reticulum, nucleus and focal adhesions, and functions in cell morphology. in Biochimica et biophysica acta 2009 (PubMed)

  6. Chicken Polyclonal SPTLC1 Primary Antibody for IHC, WB - ABIN2782713 : McCampbell, Truong, Broom, Allchorne, Gable, Cutler, Mattson, Woolf, Frosch, Harmon, Dunn, Brown: Mutant SPTLC1 dominantly inhibits serine palmitoyltransferase activity in vivo and confers an age-dependent neuropathy. in Human molecular genetics 2005 (PubMed)

  7. Chicken Polyclonal SPTLC1 Primary Antibody for WB - ABIN2782714 : Bi, Gao, Yao, Dong, Headley, Yuan: Hereditary sensory and autonomic neuropathy type I in a Chinese family: British C133W mutation exists in the Chinese. in Neuropathology : official journal of the Japanese Society of Neuropathology 2007 (PubMed)

More Antibodies against serine Palmitoyltransferase, Long Chain Base Subunit 1 Interaction Partners

Arabidopsis thaliana serine Palmitoyltransferase, Long Chain Base Subunit 1 (SPTLC1) interaction partners

  1. The roles of the LCB2a (show SPTLC2 Antibodies) and LCB2b (show SPTLC3 Antibodies) subunits in sphingolipid biosyntesis in A. thaliana were studied.

Human serine Palmitoyltransferase, Long Chain Base Subunit 1 (SPTLC1) interaction partners

  1. This study describe aberrant morphology of SPTLC1C133W Dorsal Root Ganglia characterized by increased neurite growth, branching, and expression of p-ERM (show ETV5 Antibodies) at neuronal growth cones.

  2. A novel SPTLC2 (show SPTLC2 Antibodies)-S384F variant in 2 unrelated HSAN1 families resulted in elevated plasma 1-deoxySL levels. Expression of this mutant in HEK293 cells increased 1-deoxySL formation. The substrate specificity is affected by phosphorylation at this position.

  3. Therefore, Ser331 in SPTLC1 is a crucial amino acid, which characterizes the Hereditary sensory and autonomic neuropathy type I phenotype

  4. SPTLC1 mutations cause mitochondrial abnormalities and ER stress in HSN1 cells.

  5. Endoplasmic reticulum-resident human protein serine palmitoyltransferase long chain-1 (SPTLC1) is phosphorylated at Tyr (show TYR Antibodies)(164) by the tyrosine kinase ABL.

  6. The p.CYS133Trp mutation in SPTLC1 is the most common cause of hereditary and autonomic neuropathy in the United Kingdom population.

  7. SPTLC1 mutations p.S331F and p.A352V result in a reduction of serine palmitoyltransferase activity in vitro and are associated with increased levels of the deoxysphingoid in patients' plasma samples.

  8. Hereditary sensory neuropathy type 1 is caused by a gain of function mutation in SPTLC1 which causes the accumulation of two neurotoxic sphingolipids

  9. A novel missense mutation in exon 13 of the SPTLC1 gene (c.1160G-->C; p.G387A) in twin sisters with a severe HSN (show FSCN1 Antibodies) I phenotype is reported.

  10. SPT1 aggregation preceded cell death in hypoxia and represents the first evidence of acute protein aggregation during hypoxia.

Mouse (Murine) serine Palmitoyltransferase, Long Chain Base Subunit 1 (SPTLC1) interaction partners

  1. Data suggest that overexpression of serine palmitoyltransferase (Sptlc1, serine palmitoyltransferase long chain base subunit 1) to elevate de novo sphingolipid biosynthesis induces autophagy in the liver.

  2. Both Sptlc1 and Sptlc2 (show SPTLC2 Antibodies) interactions are necessary for Serine palmitoyl-CoA transferase (SPT (show AGXT Antibodies)) activity in vivo and SPT (show AGXT Antibodies) activity directly influences plasma sphingolipid levels

  3. The expression and activities of SPT (show AGXT Antibodies) in mouse liver increased significantly following fumonisin B1 treatment

  4. Physical interaction of ABCA1 (show ABCA1 Antibodies) and SPTLC1 results in reduction of ABCA1 (show ABCA1 Antibodies) activity and that inhibition of this interaction produces enhanced cholesterol efflux.

  5. Sptlc1 deficient mice absorb less cholesterol.

serine Palmitoyltransferase, Long Chain Base Subunit 1 (SPTLC1) Antigen Profile

Protein Summary

Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5'-phosphate as a cofactor. The product of this gene is the long chain base subunit 1 of serine palmitoyltransferase. Mutations in this gene were identified in patients with hereditary sensory neuropathy type 1. Alternatively spliced variants encoding different isoforms have been identified.

Gene names and symbols associated with SPTLC1

  • serine palmitoyltransferase 1 (SPT1) antibody
  • serine palmitoyltransferase 1 (AFUA_6G00300) antibody
  • Serine palmitoyltransferase 1 (PAS_FragB_0040) antibody
  • serine palmitoyltransferase, long chain base subunit 1 (SPTLC1) antibody
  • serine palmitoyltransferase, long chain base subunit 1 (sptlc1) antibody
  • serine palmitoyltransferase, long chain base subunit 1 (Sptlc1) antibody
  • Afu6g00300 antibody
  • ATSPT1 antibody
  • AW552086 antibody
  • C77762 antibody
  • E030036H05 antibody
  • HSAN1 antibody
  • HSN1 antibody
  • LBC1 antibody
  • Lcb1 antibody
  • RGD1306617 antibody
  • serine palmitoyltransferase 1 antibody
  • Spt1 antibody
  • SPTI antibody
  • wu:fc75h04 antibody
  • wu:fp41c08 antibody
  • zgc:112247 antibody

Protein level used designations for SPTLC1

Serine palmitoyltransferase 1 , LCB 1 , SPT 1 , long chain base biosynthesis protein 1 , serine C-palmitoyltransferase , serine palmitoyltransferase 1 , serine-palmitoyl-CoA transferase 1 , fc75h04 , fp41c08 , SPT1 , serine palmitoyltransferase subunit 1 , Long chain base biosynthesis protein 1 , Serine-palmitoyl-CoA transferase 1 , serine palmitoyltransferase LCB1 subunit

GENE ID SPECIES
824039 Arabidopsis thaliana
3503652 Aspergillus fumigatus Af293
8196517 Komagataella pastoris GS115
10558 Homo sapiens
553981 Danio rerio
432022 Xenopus laevis
426145 Gallus gallus
484192 Canis lupus familiaris
614165 Bos taurus
268656 Mus musculus
361213 Rattus norvegicus
100689326 Cricetulus griseus
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