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SERPINB9 encodes a member of the serine protease inhibitor family which are also known as serpins. Additionally we are shipping SERPINB9 Proteins (8) and SERPINB9 Kits (6) and many more products for this protein.
Showing 10 out of 110 products:
Human Polyclonal SERPINB9 Primary Antibody for WB - ABIN1881792
Sprecher, Morgenstern, Mathewes, Dahlen, Schrader, Foster, Kisiel: Molecular cloning, expression, and partial characterization of two novel members of the ovalbumin family of serine proteinase inhibitors. in The Journal of biological chemistry 1996
Show all 6 references for ABIN1881792
Human Monoclonal SERPINB9 Primary Antibody for FACS, IHC (p) - ABIN180930
Hirst, Buzza, Bird, Warren, Cameron, Zhang, Ashton-Rickardt, Bird: The intracellular granzyme B inhibitor, proteinase inhibitor 9, is up-regulated during accessory cell maturation and effector cell degranulation, and its overexpression enhances CTL potency. in Journal of immunology (Baltimore, Md. : 1950) 2003
Show all 4 references for ABIN180930
Human Monoclonal SERPINB9 Primary Antibody for FACS, IHC (fro) - ABIN264518
Hirst, Buzza, Sutton, Trapani, Loveland, Bird: Perforin-independent expression of granzyme B and proteinase inhibitor 9 in human testis and placenta suggests a role for granzyme B-mediated proteolysis in reproduction. in Molecular human reproduction 2001
Show all 2 references for ABIN264518
Human Polyclonal SERPINB9 Primary Antibody for ELISA, WB - ABIN190825
Jiang, Ellison, Alarid, Shapiro: Interplay between the levels of estrogen and estrogen receptor controls the level of the granzyme inhibitor, proteinase inhibitor 9 and susceptibility to immune surveillance by natural killer cells. in Oncogene 2007
Data suggest that reactive oxygen species (ROS (show ROS1 Antibodies)) generated within cytotoxic lymphocytes by receptor stimulation are required for lysosomal permeabilization and release of GzmB (granzyme B (show Gzmb Antibodies)) into the cytosol and for inactivation of serpin B9.
the negative regulation of DC priming of CD8 (show CD8A Antibodies) T lymphocyte immunity by CTL killing is mitigated by the physiological inhibition of GrB by Spi6.
SPI-CI (show OVA Antibodies) is a novel immune escape molecule that acts in concert with SPI (show CHGA Antibodies)-6 to prevent cytotoxic lymphocyte-mediated killing of tumor cells.
Estrogen induction of PI-9 may reduce the ability of cytolytic lymphocytes-mediated immune surveillance to destroy newly transformed cells
In mCAP3 (show ST14 Antibodies), an intact catalytic triad was necessary for activation of ENaC (show SCNN1A Antibodies) but not for intramolecular cleavage of the protease.
protects hepatocytes against excessively vigorous granzyme B (show Gzmb Antibodies)-dependent killing but may also delay immune clearance of virally infected hepatocytes
deficiency in a weak intracellular inhibitor of neutrophil elastase (show ELANE Antibodies) results in an acute inflammatory response that protects from P. aeruginosa but does not cause lung disease
SPI (show CHGA Antibodies)-6 is selectively up-regulated in hepatocytes in response to infiltration of the liver by NK cells that express perforin (show PRF1 Antibodies) and enzymatically active granzyme B (show Gzmb Antibodies).
Increased SPI (show CHGA Antibodies)-6 expression is not sufficient to confer lipopolysaccharide-treated dendritic cells with resistance to direct killing in vivo.
Treatment with estrogens further increased PI-9 level while decreased that of ERalpha66 isoform thus excluding the involvement of this receptor isoform in the event. Moreover, our studies also provided evidence that tertiary tumorspheres express elevated levels of CXCR4 (show CXCR4 Antibodies) and phospho-p38 (show CRK Antibodies), suggesting that the high PI-9 content might be ascribed to the activation of the proliferative CXCR4 (show CXCR4 Antibodies)/phospho-p38 (show CRK Antibodies) axis.
We filtered four OSCC genes including SERPINB9, SERPINE2 (show SERPINE2 Antibodies), GAK (show GAK Antibodies), and HSP90B1 (show HSP90B1 Antibodies) through the gene global prioritization score (P < 0.005).
Data show that oropharyngeal squamous cell carcinomas (OPSCCs) express granzyme inhibitors SERPINB1 (show SERPINB1 Antibodies), SERPINB4 (show SERPINB4 Antibodies) and SERPINB9 for cytotoxicity and the expression was not different between human papillomavirus (HPV)-positive and HPV-negative tumors.
Pediatric CNS-PNETs evade immune recognition by downregulating cell surface MHC (show HLAE Antibodies)-I and CD1d (show CD1D Antibodies) expression. Intriguingly, expression of SERPINB9, SERPINB1 (show SERPINB1 Antibodies), and SERPINB4 (show SERPINB4 Antibodies) is acquired during tumorigenesis in 29%, 29%, and 57% of the tumors
Increased intracellular PI-9 activity in mononuclear phagocytes from HIV-infected patients contributes to successful intracellular infection by virulent Mycobacterium tuberculosis.
Suppression of granzyme B (show Gzmb Antibodies) initiated apoptosis in protease inhibitor-9-expressing leukemia cells.
SerpinB9 expression in human renal tubular epithelial cells is induced by triggering of the viral dsRNA sensors TLR3 (show TLR3 Antibodies), MDA5 (show IFIH1 Antibodies) and RIG-I (show DDX58 Antibodies) during subclinical rejection.
lung cancer cells utilise their increased PI-9 expression to protect from granzyme B (show Gzmb Antibodies)-mediated cytotoxicity as an immune evasion mechanism
Inhibition of Granzyme B (show Gzmb Antibodies) by PI-9 protects prostate cancer cells from apoptosis.
This gene encodes a member of the serine protease inhibitor family which are also known as serpins. The encoded protein belongs to a subfamily of intracellular serpins. This protein inhibits the activity of the effector molecule granzyme B. Overexpression of this protein may prevent cytotoxic T-lymphocytes from eliminating certain tumor cells. A pseudogene of this gene is found on chromosome 6.
serine (or cysteine) peptidase inhibitor, clade B, member 9
, serpin B9
, serpin peptidase inhibitor, clade B (ovalbumin), member 9
, serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 9
, Cytoplasmic antiproteinase 3
, serpin B9-like
, serine (or cysteine) proteinase inhibitor, clade B, member 9
, serine protease inhibitor 6
, cytoplasmic antiproteinase 3
, peptidase inhibitor 9
, protease inhibitor 9 (ovalbumin type)
, serpin peptidase inhibitor, clade B, member 9