SERPINB9 antibody (serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 9)

Details for Product anti-SERPINB9 Antibody No. ABIN2192172, Supplier: Log in to see
Antigen
  • SERPINB9
  • BB283241
  • CAP-3
  • CAP3
  • PI-9
  • PI9
  • Spi6
  • ovalbumin
  • serpin family B member 9
  • serpin peptidase inhibitor, clade B (ovalbumin), member 9
  • serine (or cysteine) peptidase inhibitor, clade B, member 9
  • Serpinb9
  • SERPINB9
Reactivity
Mouse (Murine)
117
25
24
3
1
1
Host
Rabbit
61
41
17
Clonality
Polyclonal
Conjugate
This SERPINB9 antibody is un-conjugated
4
4
3
3
3
3
2
1
1
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Western Blotting (WB)
106
49
35
30
29
16
7
4
4
3
1
Options
Supplier
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Sterility 0.2 μm filtered
Plasmids, Primers & others Plasmids, Primers & others SERPINB9 products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name Spi-6 (SERPINB9 Antibody Abstract)
Background The polyclonal antibody recognizes mouse Spi-6, also known as serpin B9, a cytoplasmic serine protease inhibitor of ~42 kD. Spi-6 is expressed in dendritic cells, lymphocytes and specific cell types at immune- privileged sites. It inactivates granzyme B, a natural occurring inducer of programmed cell death. As such, Spi-6 functions as anti-apoptotic protein. In cytotxic T cells (CTL), Spi-6 is required to protect clonal bursts (expansion) from granzyme B induced cell death. However, it is not required for the development of memory cells. Expression of SPI-6 is of crucial importance in the escape of several tumors from a CTL response and is, therefore, a parameter that influences the feasibility of CTL-mediated immunotherapy of cancer. The polyclonal antibody shows no crossreactivity with mouse proteins related to Spi-6. Aliases Cytoplasmic antiproteinase 3, serpin B9, PI-9 Immunogen Recombinant GST-Spi-6
Application Notes For flow cytometry and Western blotting, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.
Restrictions For Research Use only
Buffer PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
Expiry Date 12 months
Product cited in: Zhang, Byrne, Liu, Wang, Oxenius, Ashton-Rickardt: "Differential survival of cytotoxic T cells and memory cell precursors." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 178, Issue 6, pp. 3483-91, 2007 (PubMed).

Zhang, Liu, Park, Wang, Byrne, Murmann, Bahr, Peter, Olson, Belaaouaj, Ashton-Rickardt: "Serine protease inhibitor 6-deficient mice have increased neutrophil immunity to Pseudomonas aeruginosa." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 179, Issue 7, pp. 4390-6, 2007 (PubMed).

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