Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all species
Show all synonyms
Select your species and application
anti-Human PRKAA2 Antibodies:
anti-Rat (Rattus) PRKAA2 Antibodies:
anti-Mouse (Murine) PRKAA2 Antibodies:
Go to our pre-filtered search.
Cow (Bovine) Polyclonal PRKAA2 Primary Antibody for WB - ABIN151705
Rubin, Magliola, Feng, Jones, Hale: Metabolic activation of AMP kinase in vascular smooth muscle. in Journal of applied physiology (Bethesda, Md. : 1985) 2004
Show all 3 Pubmed References
Human Polyclonal PRKAA2 Primary Antibody for IF (p), IHC (p) - ABIN680458
Fu, Zhu, Dodson, Du: AMP-activated protein kinase stimulates Warburg-like glycolysis and activation of satellite cells during muscle regeneration. in The Journal of biological chemistry 2015
Show all 2 Pubmed References
Human Polyclonal PRKAA2 Primary Antibody for ELISA, EIA - ABIN4280438
Dong, Zhang, Liang, Xie, Zhao, Asfa, Choi, Zou: Reduction of AMP-activated protein kinase alpha2 increases endoplasmic reticulum stress and atherosclerosis in vivo. in Circulation 2010
Cow (Bovine) Polyclonal PRKAA2 Primary Antibody for IP - ABIN153316
Gusarova, Dada, Kelly, Brodie, Witters, Chandel, Sznajder: Alpha1-AMP-activated protein kinase regulates hypoxia-induced Na,K-ATPase endocytosis via direct phosphorylation of protein kinase C zeta. in Molecular and cellular biology 2009
TNF-alpha (show TNF Antibodies) treatment of colonic rho(0) cells augmented IL-8 (show IL8 Antibodies) expression by 9-fold (P < 0.01) via NF-kappaB (show NFKB1 Antibodies) compared to TNF-alpha (show TNF Antibodies)-treated control. Moreover, reduced mitochondrial function facilitated TNF-alpha (show TNF Antibodies)-mediated NF-kappaB (show NFKB1 Antibodies) luciferase promoter activity as a result of lowered inhibitory IkappaBalpha (show NFKBIA Antibodies) (nuclear factor of kappa light polypeptide gene enhancer in B-cell inhibitor, alpha), leading to elevated NF-kappaB (show NFKB1 Antibodies). ...
Results highlight the contribution of AMPKalpha2 as a mechanism for controlling bladder cancer growth by regulating proliferation through mTOR (show FRAP1 Antibodies) suppression and induction of p27 (show PAK2 Antibodies) protein levels, thus indicating how AMPKalpha2 loss may contribute to tumorigenesis.
AMPK (show PRKAA1 Antibodies) phosphorylation of cortactin (show CTTN Antibodies) followed by SIRT1 (show SIRT1 Antibodies) deacetylation modulates the interaction of cortactin (show CTTN Antibodies) and cortical-actin in response to shear stress. Functionally, this AMPK (show PRKAA1 Antibodies)/SIRT1 (show SIRT1 Antibodies) coregulated cortactin (show CTTN Antibodies)-F-actin dynamics is required for endothelial nitric oxide synthase (show NOS3 Antibodies) subcellular translocation/activation and is atheroprotective.
Data suggest that the AMPK (show PRKAA1 Antibodies)-TBC1D4 (show TBC1D4 Antibodies) signaling axis is likely mediating the improved muscle insulin (show INS Antibodies) sensitivity after contraction/exercise and illuminates an important and physiologically relevant role of AMPK (show PRKAA1 Antibodies) in skeletal muscle.
inactivation of AMPKalpha2, but not AMPKalpha1 (show PRKAA1 Antibodies), abrogates the tumor attenuation caused by UBE2O (show UBE2O Antibodies) loss.
Our findings demonstrate that the AMPKalpha2 catalytic subunit in Kiss1 (show KISS1 Antibodies) cells is dispensable for body weight and reproductive function in mice but is necessary for the reproductive adaptations to conditions of acute metabolic distress.
Binding of miR (show MLXIP Antibodies)-27a to the 3'-UTR (show UTS2R Antibodies) of the AMPKalpha2 gene was required to increase the sensitivity of breast cancer cells to metformin.
human cells were infected with lentiviruses expressing shRNA targeting both alpha1 and alpha2 AMPK (show PRKAA1 Antibodies) subunits. AMPK (show PRKAA1 Antibodies) activation inhibits Gli1 (show GLI1 Antibodies)-driven proliferation and that this effect is linked to Ser408 phosphorylation, which represents a key metabolic checkpoint for Hh signaling.
These data are in accordance with R6 binding directly to AMPKbeta2 when both proteins detach from the diminishing glycogen (show GYS1 Antibodies) particle, which is simultaneous with increased AMPKbeta2 Thr (show TRH Antibodies)-148 autophosphorylation.
p-AMPKalpha (show GRK4 Antibodies) was associated with cervical carcinogenesis, and high expression of AMPKalpha2 was correlated with better disease-free survival in patients with early-stage cervical cancer
Endometrial inflammatory responses to lipopolysaccharide were also reduced by small molecules that activate or inhibit the intracellular sensor of energy, AMP-activated protein kinase (AMPK).
The investigation of PRKAA2 genetic polymorphisms in three Chinese indigenous bovine breeds [Qinchuan (n = 328), Nanyang (n = 278), Jiaxian (n = 148)] and yak (n = 57), is reported.
These data show that the AMPK (show PRKAA1 Antibodies) activator AICAR (show ATIC Antibodies) is inhibitory to nuclear maturation in bovine oocytes due to activation of AMPK (show PRKAA1 Antibodies) [AMP-activated protein kinase alpha (show PAK1 Antibodies) 1 subunit].
High AMPKalpha2 phosphorylation is associated with abdominal aortic aneurysm.
Rac1 and AMPK (show PRKAA1 Antibodies) together account for almost the entire ex vivo contraction response in muscle glucose transport, whereas only Rac1, but not alpha2 AMPK (show PRKAA1 Antibodies), regulates muscle glucose uptake during submaximal exercise in vivo.
we used the Cre-loxP system to knock down AMPKalpha2 expression in renal epithelial cells. Combining this approach with the systemic deletion of AMPKalpha1 (show PRKAA1 Antibodies) we achieved reduced renal AMPK (show PRKAA1 Antibodies) activity, accompanied by a shift to a moderate water- and salt-wasting phenotype. Thus we confirm the physiologically relevant role of AMPK (show PRKAA1 Antibodies) in the kidney.
Findings show that decreased AMPK (show PRKAA1 Antibodies) activity in muscle leads to decreased voluntary activity which is not due to secondary abnormalities in dopamine levels in the ventral striatum or sensitivity to cocaine. Thus, decreased voluntary activity in AMPK (show PRKAA1 Antibodies) muscle deficient mice is most likely unrelated to regulation of brain dopamine content and metabolism.
Hypoxia reduces HNF4alpha/MODY1 (show HNF4A Antibodies) protein expression in pancreatic beta-cells by activating AMP-activated protein kinase.
These studies reveal a novel mechanism in which CYP2J2 (show CYP2J2 Antibodies) and epoxyeicosatrienoic acids enhanced Akt1 (show AKT1 Antibodies) nuclear translocation through interaction with AMPKalpha2beta2gamma1 and protect against cardiac hypertrophy.
Loss of AMPKalpha2 is associated with impaired control of vesicular stomatitis virus infection.
AMPK (show PRKAA1 Antibodies)-mediated HSPB1 (show HSPB1 Antibodies) expression enhanced insulin (show INS Antibodies) sensitivity in the skeletal muscle.
Single SNP and haplotype analyses revealed weak associations between the PRKAA2 genotypes and loin muscle area in the investigated populations.
The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.
SNF1-like protein AMPK
, 5'-AMP-activated protein kinase catalytic subunit alpha-2
, 5'-AMP-activated protein kinase alpha-2 catalytic subunit
, protein kinase, AMP-activated, alpha 2 catalytic subunit
, AMP-activated protein kinase alpha 2 catalytic subunit
, ACACA kinase
, AMPK subunit alpha-2
, HMGCR kinase
, acetyl-CoA carboxylase kinase
, hydroxymethylglutaryl-CoA reductase kinase
, 5'-AMP-activated protein kinase, catalytic alpha-2 chain
, AMPK-alpha-2 chain
, AMP-activated protein kinase
, AMPK alpha-2 chain
, AMP-activated protein kinase alpha-2 variant B
, AMP-activated protein kinase alpha 2
, protein kinase AMP-activated alpha 2 catalytic subunit
, AMPK-activated protein kinase alpha-2 subunit