beta-2 Microglobulin antibody

Catalog No. ABIN1045266

Product Details anti-beta-2 Microglobulin Antibody

Target: beta-2 Microglobulin (B2M) (beta-2-Microglobulin (B2M))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This beta-2 Microglobulin antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Specificity: Specific for B2M denatured and native forms

Cross-Reactivity: Human

Purification: Protein G purified

Purity: > 95 %

Immunogen: Recombinant human Beta-2-microglobulin protein

Clone: 2D3E5

Isotype: IgG1, IgG1 kappa

Application Details

Application Notes: Recommended dilution:IHC:1:50-1:500,

Comment:

Other species are not tested. Please decide the specificity by homology

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid freeze and thaw cycles.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

References for anti-beta-2 Microglobulin antibody (ABIN1045266)

Stefanović, Djukanović, Cukuranović, Bukvić, Ležaić, Marić, Ogrizovic, Jovanović, Vlahovic, Pešić, Djordjević: "Beta2-microglobulin and alpha1-microglobulin as markers of Balkan endemic nephropathy, a worldwide disease." in: Renal failure, Vol. 33, Issue 2, pp. 176-83, (2011) (PubMed).

Sharifiaghdas, Kashi, Eshratkhah: "Evaluating percutaneous nephrolithotomy-induced kidney damage by measuring urinary concentrations of β2-microglobulin." in: Urology journal, Vol. 8, Issue 4, pp. 277-82, (2011) (PubMed).

Johnston, Cassidy, OConnell, ORiordan, Gallagher, Maguire, Wynne, Cagney, Ryan, Conlon, McMorrow: "Identification of β2-microglobulin as a urinary biomarker for chronic allograft nephropathy using proteomic methods." in: Proteomics. Clinical applications, Vol. 5, Issue 7-8, pp. 422-31, (2011) (PubMed).

Kals, Zagura, Serg, Kampus, Zilmer, Unt, Lieberg, Eha, Peetsalu, Zilmer: "β2-microglobulin, a novel biomarker of peripheral arterial disease, independently predicts aortic stiffness in these patients." in: Scandinavian journal of clinical and laboratory investigation, Vol. 71, Issue 4, pp. 257-63, (2011) (PubMed).

Dieterle, Perentes, Cordier, Roth, Verdes, Grenet, Pantano, Moulin, Wahl, Mahl, End, Staedtler, Legay, Carl, Laurie, Chibout, Vonderscher, Maurer: "Urinary clusterin, cystatin C, beta2-microglobulin and total protein as markers to detect drug-induced kidney injury." in: Nature biotechnology, Vol. 28, Issue 5, pp. 463-9, (2010) (PubMed).

Target Details for beta-2 Microglobulin

Target: beta-2 Microglobulin (B2M) (beta-2-Microglobulin (B2M))

Alternative Name: B2M (B2M Products)

Synonyms: Ly-m11 antibody, beta2-m antibody, beta2m antibody, bwm antibody, wu:fa94c05 antibody, wu:fb10a09 antibody, b2m-W01 antibody, b2m-W03 antibody, b2m-Z01 antibody, b2m-Z02 antibody, b2m-Z03 antibody, B2M antibody, b2m antibody, B2MG antibody, wu:fb66f11 antibody, wu:fj01f08 antibody, zgc:64161 antibody, b-2-m antibody, beta-2-microglobulin antibody, beta-2 microglobulin antibody, beta-2-microglobulin S homeolog antibody, beta-2-microglobulin, like antibody, B2M antibody, B2m antibody, b2m antibody, b2m.S antibody, b2ml antibody

Background:

Background: Beta 2 Microglobulin non-covalently associates with the 44 kDa alpha chain to form the HLA Class I antigen complex. Human beta 2 Microglobulin associated with HLA Class I antigens are expressed on many types of cells including lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial cells, and epithelial cells. It is absent on erythrocytes.

Aliases: B2M, CDABP0092, HDCMA22P

UniProt: P61769

Pathways: TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process