VTCN1 antibody
-
- Target See all VTCN1 Antibodies
- VTCN1 (V-Set Domain Containing T Cell Activation Inhibitor 1 (VTCN1))
-
Reactivity
- Human, Mouse
-
Host
- Rabbit
-
Clonality
- Monoclonal
-
Conjugate
- This VTCN1 antibody is un-conjugated
-
Application
- Western Blotting (WB), ELISA
- Purification
- Affinity chromatography purified via peptide column
- Immunogen
- Rabbit polyclonal VTCN1 antibody was raised against an 18 amino acid peptide near the center of human VTCN1.
- Isotype
- IgG
- Top Product
- Discover our top product VTCN1 Primary Antibody
-
-
- Application Notes
- VTCN1 antibody can be used for detection of VTCN1 by Western blot at 1 - 2 μg/mL.
- Comment
-
(IN) V-set domain containing T cell activation inhibitor 1
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS containing 0.02 % Sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- Storage
- 4 °C/-20 °C
- Storage Comment
- VTCN1 antibody can be stored at 4 °C for three months. At -20 °C stable for up to one year.
- Expiry Date
- 12 months
-
- Target
- VTCN1 (V-Set Domain Containing T Cell Activation Inhibitor 1 (VTCN1))
- Alternative Name
- VTCN1 (VTCN1 Products)
- Synonyms
- B7h4 antibody, B7s1 antibody, B7x antibody, BC032925 antibody, B7-H4 antibody, B7H4 antibody, B7S1 antibody, B7X antibody, B7h.5 antibody, PRO1291 antibody, VCTN1 antibody, RGD1311204 antibody, V set domain containing T cell activation inhibitor 1 L homeolog antibody, V-set domain containing T cell activation inhibitor 1 antibody, V-set domain containing T-cell activation inhibitor 1 antibody, V set domain containing T cell activation inhibitor 1 antibody, vtcn1.L antibody, VTCN1 antibody, vtcn1 antibody, Vtcn1 antibody
- Background
-
T cell immunity plays a critical role in host immune surveillance of tumour cell growth and metastatic spread. VTCN1, also known as B7-H4, is a member of the B7 family of immune regulatory molecules. Expressed primarily on the membrane of lymphoid cells, VTCN1 is an immunoinhibitory protein that interacts with receptors on the surface of T lymphocytes, thus mediating cellular and humoral immune responses. Overexpression of VTCN1 is associated with certain malignancies, including ovarian and breast cancer, which may be a mechanism by which tumour cells suppress T cell immunity and facilitate tumour progression. VTCN1 may thus be a useful biomarker for the early detection of ovarian cancer.
Synonyms: V-set domain containing T cell activation inhibitor 1, T cell costimulatory molecule B7x, B7-H4, B7H4, B7S1, B7X - Molecular Weight
- 31 kDa (calculated)
- Gene ID
- 79679
- NCBI Accession
- NP_078902
-