FGFR2 antibody (C-Term)

Catalog No. ABIN1106281

Product Details anti-FGFR2 Antibody

Target: FGFR2 (Fibroblast Growth Factor Receptor 2 (FGFR2))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FGFR2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: Recognizes CD332 / FGFR-2. No cross reactivity with other proteins.

Cross-Reactivity (Details): Species reactivity (expected):Rat.
Species reactivity (tested):Human, Mouse.

Purification: Immunoaffinity Chromatography

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminal of Human FGFR2, identical to the related Rat and Mouse sequence.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Reconstitution: Restore with 0.2 mL of distilled water to yield a concentration of 0.5 mg/mL.

Concentration: 0.5 mg/mL

Buffer: 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal and 0.05 mg Sodium Azide

Preservative: Sodium azide, Thimerosal (Merthiolate)

Precaution of Use: This product contains Sodium azide and Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody after reconstitution at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for FGFR2

Target: FGFR2 (Fibroblast Growth Factor Receptor 2 (FGFR2))

Alternative Name: CD332 / FGFR-2 (FGFR2 Products)

Synonyms: FGFR2 antibody, FGFR2IIIb antibody, bek antibody, bfr-1 antibody, cd332 antibody, cek3 antibody, cfd1 antibody, ect1 antibody, fgfr-2 antibody, jws antibody, k-sam antibody, kgfr antibody, tk14 antibody, tk25 antibody, xfgfr2 antibody, DKFZp469H1521 antibody, BBDS antibody, BEK antibody, BFR-1 antibody, CD332 antibody, CEK3 antibody, CFD1 antibody, ECT1 antibody, JWS antibody, K-SAM antibody, KGFR antibody, TK14 antibody, TK25 antibody, AU043015 antibody, AW556123 antibody, Bek antibody, Fgfr-2 antibody, Fgfr-7 antibody, Fgfr7 antibody, KGFRTr antibody, svs antibody, FGF-R antibody, fgfr72IIIb antibody, FGFR antibody, fc56c05 antibody, wu:fc56c05 antibody, fibroblast growth factor receptor 2 antibody, fibroblast growth factor receptor 2 L homeolog antibody, FGFR2 antibody, LOC100084641 antibody, fgfr2 antibody, Fgfr2 antibody, fgfr2.L antibody

Background: Fibroblast growth factor receptor 2 (FGFR2) is a receptor for fibroblast growth factor encoded on a gene residing on chromosome 10. FGFR2 has also been designated as CD332. FGFR2 is a membrane-spanning tyrosine kinase that serves as a high affinity receptor for several members of the fibroblast growth factor (FGF) family. Its signals are absolutely required for vertebrate limb induction and that an FGFR2 signal is essential for the reciprocal regulation loop between FGF8 and FGF10 during limb induction. (1) FGFR2 contributes to the outgrowth, differentiation, and maintenance of the inner cell mass and raise the possibility that this activity is mediated by FGF4 signals transmitted by FGFR2. The role of early FGF signaling in pregastrulation development as a possible adaptation to mammalian (amniote) embryogenesis is discussed. (2)Synonyms: BEK, FGFR2, Fibroblast growth factor receptor 2, KGFR, KSAM, Keratinocyte growth factor receptor 2

Gene ID: 2263

NCBI Accession: NP_000132

UniProt: P21802

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Growth Factor Binding