Protein tyrosine Phosphatase, Receptor Type, C (PTPRC) antibody (PE)

Details for Product No. ABIN1106410
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Antigen
Synonyms B220, CD45, CD45R, GP180, L-CA, LCA, LY5, T200, Lca, RT7, Cd45, Ly-5, Lyt-4, loc, cd45, PTPRC, si:dkeyp-47c5.1
Reactivity
Human
(621), (457), (132), (54), (40), (36), (31), (19), (18), (5), (5), (4), (3), (2), (2), (1)
Host
Mouse
(669), (432), (129), (2), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
PE
(181), (119), (113), (62), (26), (19), (11), (10), (10), (9), (9), (9), (8), (8), (7), (6), (6), (5), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Flow Cytometry (FACS)
(965), (210), (199), (194), (167), (129), (90), (83), (66), (40), (13), (7), (6), (4), (2), (2), (2), (1), (1), (1)
Pubmed 6 references available
Catalog no. ABIN1106410
Quantity 100 tests
Price
566.50 $   Plus shipping costs $45.00
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Clone MT4
Isotype IgG1
Specificity Clone MT4 reacts with the 190, 205 and 220 kD isoforms of the cell-surface antigen CD45RB. Variations in CD45RB expression can discriminate between Th1 and Th 2 cells, i.e. CD45RBbright and CD45RB-dim respectively [8]. CD45RB bright expression on T cells correlates with higher proliferation and IFN-g production in comparison to CD45RB dim expression. 90% of lymphocytes are CD45RB positive. Other isoforms can be detected using anti-CD45RA (clone MB1, cat.no. AM39020), or anti- CD45RC (clone MT2, cat.no. AM39022).
Purification Affinity chromatography
Alternative Name CD45 / LCA
Background The CD45 molecule is also known as the Leukocyte Common Antigen (LCA) or T200 antigen, and is comprised of different glycoproteins ranging from 180-240 kD [1,2]. CD45 is a family of transmembrane protein tyrosine phosphatases critically involved in the regulation of lymphocyte activation signals. Expression of CD45 is found on all hemopoietic cells, e.g. granulocytes, monocytes, macrophages and lymphocytes, except mature erythroid cells. In humans, there is heterogeneous expression of CD45 isoforms (RA, RB, RO, RC) on lymphocyte subpopulations. Detection of the different isoforms can distinguish, for example, between naive T cells and memory T cells, which is of interest in patients with immunodeficiency and autoimmune diseases.
Alternate names: L-CA, Leukocyte common antigen, PTPRC, Receptor-type tyrosine-protein phosphatase C, T200
Gene ID 5788
NCBI Accession NP_002829
UniProt P08575
Restrictions For Research Use only
Format Liquid
Buffer 0.01 M sodium phosphate, 0.15 M NaCl, pH 7.3, 0.2% BSA, 0.09% sodium azide
Preservative Sodium azide
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8°C. Fluorochrome labelled product is photosensitive and should be protected from light.
Expiry Date 12 months
Supplier Images
anti-Protein tyrosine Phosphatase, Receptor Type, C (PTPRC) antibody (PE) anti-Protein tyrosine Phosphatase, Receptor Type, C (PTPRC) antibody (PE)
Background publications Thomas: "The leukocyte common antigen family." in: Annual review of immunology, Vol. 7, pp. 339-69, 1989 (PubMed).

Streuli, Hall, Saga et al.: "Differential usage of three exons generates at least five different mRNAs encoding human leukocyte common antigens." in: The Journal of experimental medicine, Vol. 166, Issue 5, pp. 1548-66, 1987 (PubMed).

Poppema, Hollema, Visser et al.: "Monoclonal antibodies (MT1, MT2, MB1, MB2, MB3) reactive with leukocyte subsets in paraffin-embedded tissue sections." in: The American journal of pathology, Vol. 127, Issue 3, pp. 418-29, 1987 (PubMed).

West, Warford, Fray et al.: "The demonstration of B-cell, T-cell and myeloid antigens in paraffin sections." in: The Journal of pathology, Vol. 150, Issue 2, pp. 89-101, 1987 (PubMed).

Hall, DArdenne, Butler et al.: "New marker of B lymphocytes, MB2: comparison with other lymphocyte subset markers active in conventionally processed tissue sections." in: Journal of clinical pathology, Vol. 40, Issue 2, pp. 151-6, 1987 (PubMed).

Young, Ramage, Gaston et al.: "In vitro responses of human CD45R0brightRA- and CD45R0-RAbright T cell subsets and their relationship to memory and naive T cells." in: European journal of immunology, Vol. 27, Issue 9, pp. 2383-90, 1997 (PubMed).

Hosts (669), (432), (129), (2), (1)
Reactivities (621), (457), (132), (54), (40), (36), (31), (19), (18), (5), (5), (4), (3), (2), (2), (1)
Applications (965), (210), (199), (194), (167), (129), (90), (83), (66), (40), (13), (7), (6), (4), (2), (2), (2), (1), (1), (1)
Conjugates (181), (119), (113), (62), (26), (19), (11), (10), (10), (9), (9), (9), (8), (8), (7), (6), (6), (5), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (20), (10), (7), (6), (4), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
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