PLVAP antibody (Plasmalemma Vesicle Associated Protein)

Details for Product anti-PLVAP Antibody No. ABIN1108672, Supplier: Log in to see
Antigen
  • MECA32
  • Pv1
  • FELS
  • PV-1
  • PV1
  • gp68
  • plasmalemma vesicle associated protein
  • plasmalemma vesicle associated protein-like
  • Plvap
  • PLVAP
  • LOC100343789
Reactivity
Human
38
21
1
Host
Mouse
30
21
8
Clonality (Clone)
Monoclonal ()
Conjugate
This PLVAP antibody is un-conjugated
11
6
2
2
2
2
1
1
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Western Blotting (WB)
44
36
19
14
13
8
5
4
4
1
1
1
1
Options
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Clone 174-2
Isotype IgG1
Specificity This antibody reacts with human plasmalemma vesicle associated protein (PLVAP).
Cross-Reactivity (Details) Species reactivity (tested):Human
Purification Protein G
Alternative Name PLVAP (PLVAP Antibody Abstract)
Background PLVAP is a 60 kDa type II transmembrane glycoprotein which tends to form homodimers. PLVAP is widely expressed in the vasculature of normal tissues. The vascular staining pattern of PLVAP is quite unique among the endothelial cell antigens, since expression of other antigens (like ICAM-1, P-selectin, E-selectin or VCAM-1) is not limited to vascular endothelial cells. PLVAP expression in the vascular endothelial cells of the CNS is lost in association with formation of an intact blood-brain barrier. However, in the endothelium of human brain tumors expression of PLVAP is specifically up-regulated, making it a suitable antiangiogenic target for brain tumor therapy and cerebral edema. Furthermore, PLVAP is expressed in the vasculature of most other human tumors and as such useful as marker for tumor angiogenesis.Synonyms: Endothelial Cell Antigen, Endothelial cell marker, Endothelial cell surface marker, FELS, Fenestrated endothelial-linked structure protein, MECA-32 antigen, PV-1, PV1, Plasmalemma vesicle protein 1, Plasmalemma vesicle-associated protein
Gene ID 83483
NCBI Accession NP_112600
UniProt Q9BX97
Research Area Organelles
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0.1 mg/mL
Buffer PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store at 2 - 8 °C.
Background publications Niemelä, Elima, Henttinen, Irjala, Salmi, Jalkanen: "Molecular identification of PAL-E, a widely used endothelial-cell marker." in: Blood, Vol. 106, Issue 10, pp. 3405-9, 2005 (PubMed).

Carson-Walter, Hampton, Shue, Geynisman, Pillai, Sathanoori, Madden, Hamilton, Walter: "Plasmalemmal vesicle associated protein-1 is a novel marker implicated in brain tumor angiogenesis." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 11, Issue 21, pp. 7643-50, 2005 (PubMed).