Aqueous buffered solution containing BSA and ≤0.09 % sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C
Storage Comment
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. The antibody was conjugated to Alexa Fluor® 647 under optimum conditions, and unreacted Alexa Fluor® 647 was removed.
Target
WIPF1
(WAS/WASL Interacting Protein Family, Member 1 (WIPF1))
WASPIP antibody, PRPL-2 antibody, WIP antibody, AI115543 antibody, D2Ertd120e antibody, Waspip antibody, Wip antibody, WAS/WASL interacting protein family member 1 antibody, WAS/WASL interacting protein family, member 1 antibody, WIPF1 antibody, Wipf1 antibody
Background
Wiskott-Adrich syndrome protein (WASP)-Interacting Protein (WIP) is a member of the verprolin family of proteins that regulate cytoskeletal organization in a wide variety of cellular activities, including endocytosis, cellular adhesion and migration, mast cell degranulation, and lymphocyte activation. The 503-amino acid WIP protein contains binding sites for actin (globular and filamentous) and other proteins that are involved in the regulation of actin polymerization, such as WASP, N-WASP, profilin, cortactin, Hck, and NCK. As its functions imply, WIP is localized in actin-rich cell structures. The K32-824 monoclonal antibody recognizes the phosphorylated serine 488 (pS488) of human WIP. The orthologous phosphorylation sites in mouse and rat WIP are S478 and S472, respectively. Synonyms: PRPL-2 protein, WAIP, WASIP, WASPIP