HLA-ABC (HLA-ABC) antibody

Details for Product No. ABIN1177256, Supplier: Log in to see
Antigen
  • HLAA
  • major histocompatibility complex, class I, A
  • HLA-A
Alternatives
anti-Human HLA-ABC antibody for Flow Cytometry
Reactivity
Human
149
40
35
24
18
16
15
15
9
8
8
4
4
3
3
Host
Mouse
128
18
4
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
16
14
11
5
4
4
4
3
3
3
3
3
3
3
3
2
1
1
1
Application
Blocking Reagent (BR), Flow Cytometry (FACS)
124
55
35
30
27
26
24
14
7
2
1
1
1
1
Options
Supplier
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Supplier Product No.
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Brand BD Pharmingen™
Immunogen Polyclonal Human NK Cell Line
Clone DX17
Isotype IgG1, kappa
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Sterility 0.2 μm filtered
Endotoxin Level Endotoxin level is ≤ 0.01 EU/μg (≤ 0.001 ng/μg) of protein as determined by the LAL assay.
Alternative Name HLA-A/B/C (HLA-ABC Antibody Abstract)
Background The DX17 monoclonal antibody reacts with a monomorphic epitope expressed on all HLA (human leukocyte antigen) class I molecules examined. DX17 immunoprecipitates HLA class I heavy chains (45 kDa) and beta2-microglobulin (12kDa) from radiolabeled human cell lines. HLA is determined by a complex segment of the short arm of chromosome 6 and there are many human HLAs encoded in this segment. The antigenic agglomerate is called MHC, for major histocompatibility complex. Examples of class I loci are HLA-A, -B, and -C, which are serologically assayed, class II loci, e.g., HLA-D/DR and DC1, are tested by lymphocytotoxic methods.
Pathways TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.
Preservative Azide free
Storage 4 °C
Storage Comment Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
Supplier Images
Flow Cytometry (FACS) image for anti-HLA-ABC (HLA-ABC) antibody (ABIN1177256) anti-HLA-ABC (HLA-ABC) antibody
Product cited in: Gumperz, Litwin, Phillips, Lanier, Parham: "The Bw4 public epitope of HLA-B molecules confers reactivity with natural killer cell clones that express NKB1, a putative HLA receptor." in: The Journal of experimental medicine, Vol. 181, Issue 3, pp. 1133-44, 1995 (PubMed).

Lanier, Gumperz, Parham, Melero, López-Botet, Phillips: "The NKB1 and HP-3E4 NK cells receptors are structurally distinct glycoproteins and independently recognize polymorphic HLA-B and HLA-C molecules." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 154, Issue 7, pp. 3320-7, 1995 (PubMed).

Morton, Kirsch, Nance, Evans, Korman, Strominger: "Orientation of loci within the human major histocompatibility complex by chromosomal in situ hybridization." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 81, Issue 9, pp. 2816-20, 1984 (PubMed).

Bach, Amos: "Hu-1: Major histocompatibility locus in man." in: Science (New York, N.Y.), Vol. 156, Issue 3781, pp. 1506-8, 1970 (PubMed).

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