Integrin Alpha2b (CD41) antibody

Details for Product No. ABIN118658
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Antigen
Synonyms GPIIB
Reactivity
Human
(195), (77), (20), (12), (3), (2), (2), (1)
Host
Mouse
(180), (61), (26)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(44), (28), (24), (7), (6), (4), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Flow Cytometry (FACS)
(206), (50), (43), (35), (29), (24), (18), (10), (9), (6), (5), (2), (1)
Pubmed 2 references available
Catalog no. ABIN118658
Quantity 0.2 mg
Price
467.50 $   Plus shipping costs $45.00
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Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Human platelet plasma membrane. Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line.
Clone PM6-248
Isotype IgG1
Specificity This antibody recognises the CD41 cell surface antigen. It has not been established if clone PM6/248 recognises free CD41 or CD41 only when complexed with CD61. However, antibody binding is reduced in the presence of EDTA suggesting that the epitope recognised is dependent upon an intact CD41/61 complex.
Purification Affinity chromatography on Protein G
Alternative Name CD41 / ITGA2B
Background CD41 is a 140kD glycoprotein expressed by platelets and megakaryocytes. CD41 is also known as platelet glycoprotein IIb, and functions as a receptor for fibrinogen, fibronectin and vWF.
Alternate names: GP2B, GPalpha IIb, ITGAB, Integrin alpha-IIb, Platelet membrane glycoprotein IIb
NCBI Accession 9606
UniProt P08514
Application Notes Flow cytometry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0mg/mL
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Hornby, Brown, Wilkinson et al.: "Activation of human platelets by exposure to a monoclonal antibody, PM6/248, to glycoprotein IIb-IIIa." in: British journal of haematology, Vol. 79, Issue 2, pp. 277-85, 1992 (PubMed).

General Michelson, Page, Casey et al.: "An eosinophilia-myalgia syndrome related disorder associated with exposure to L-5-hydroxytryptophan." in: The Journal of rheumatology, Vol. 21, Issue 12, pp. 2261-5, 1995 (PubMed).

Hosts (180), (61), (26)
Reactivities (195), (77), (20), (12), (3), (2), (2), (1)
Applications (206), (50), (43), (35), (29), (24), (18), (10), (9), (6), (5), (2), (1)
Conjugates (44), (28), (24), (7), (6), (4), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (7), (4), (1), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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