FCAR antibody

Catalog No. ABIN118855

Product Details anti-FCAR Antibody

Target: FCAR (Fc Fragment of IgA, Receptor For (FCAR))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This FCAR antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP), Enzyme Immunoassay (EIA)

Specificity: This antibody recognises the CD89 cell surface antigen. Clone MIP8a blocks binding of IgA to the Fc alpha R, and also inhibits neutrophil phagocytosis of IgA complexes. The preservative free format of this antibody (product code SM1198A) is recommended for functional studies.

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Purified

Immunogen: Recombinant soluble Human Fc alpha R

Clone: MIP8a

Isotype: IgG1

Application Details

Application Notes: Flow Cytometry: Use 10 μL of 1/50-1/100 diluted antibody to label 10^6 cells or 100 μL whole blood. ELISA. Immunoprecipitation. Western Blot.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.09 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for FCAR

Target: FCAR (Fc Fragment of IgA, Receptor For (FCAR))

Alternative Name: CD89 / FCAR (FCAR Products)

Synonyms: CD89 antibody, Fc fragment of IgA receptor antibody, Fc fragment of IgA, receptor for antibody, FCAR antibody

Background: CD89 cell surface antigen is a 50-70kD glycoprotein that is also known as the IgA receptor. CD89 is expressed by peripheral blood neutrophils and monocytes. Human CD89 is present on a number of cell types, including neutrophils, monocytes, macrophages, and eosinophils. FCAR interacts with aggregated IgAs, such as IgA coated on the surface of an invading microorganism, and mediates several immunologic defense processes such as phagocytosis, antibody dependent cell mediated cytotoxicity, and stimulation of the release of inflammatory mediators. FCAR is a glycoprotein of 50 to 100 kD, with diversity on different cell types.Synonyms: IgA Fc receptor, Immunoglobulin alpha Fc receptor

Gene ID: 2204

NCBI Accession: NP_001991

UniProt: P24071