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FCAR Products

(Fc Fragment of IgA, Receptor For (FCAR))

Categories

This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008].

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Featured FCAR Categories

FCAR Antibodies

High quality antibodies with extensive validation data.

FCAR ELISA Kits

Reliable ELISA kits for a wide range of species.

FCAR Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended FCAR Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, FACS, IHC, ICC, Neut
Validations
  • (4)
Cat. No. ABIN5684138
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Rat
Application WB, IHC, IP, ICC
Validations
  • (3)
Cat. No. ABIN7443131
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Non-Human Primate
Application FACS
Validations
  • (2)
Cat. No. ABIN4888509
Quantity 0.1 mg
Datasheet Datasheet

Recommended FCAR ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN6955737
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN4882811
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN627006
Quantity 96 tests
Datasheet Datasheet

Recommended FCAR Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (2)
Cat. No. ABIN7274249
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1353885
Quantity 10 μg
Datasheet Datasheet
Reactivity Rat
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN7321241
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our FCAR products

Björklund, Carlsten, Sohlberg, Liu, Clancy, Karimi, Cooley, Miller, Klimkowska, Schaffer, Watz, Wikström, Blomberg, Wahlin, Palma, Hansson, Ljungman, Hellström-Lindberg, Ljunggren, Malmberg: "Complete Remission with Reduction of High-Risk Clones following Haploidentical NK-Cell Therapy against MDS and AML." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 24, Issue 8, pp. 1834-1844, (2018) (PubMed).

Moresco, Speeckaert, Zmonarski, Krajewska, Komuda-Leszek, Perkowska-Ptasinska, Gesualdo, Rocchetti, Delanghe, Vanholder, Van Biesen, Delanghe: "Urinary myeloid IgA Fc alpha receptor (CD89) and transglutaminase-2 as new biomarkers for active IgA nephropathy and henoch-Schönlein purpura nephritis." in: BBA clinical, Vol. 5, pp. 79-84, (2016) (PubMed).

Matt, Lindqvist, Kleinau: "Elevated Membrane and Soluble CD64: A Novel Marker Reflecting Altered Fc?R Function and Disease in Early Rheumatoid Arthritis That Can Be Regulated by Anti-Rheumatic Treatment." in: PLoS ONE, Vol. 10, Issue 9, pp. e0137474, (2015) (PubMed).

Lu, Marjon, Marnell, Wang, Mold, Du Clos, Sun: "Recognition and functional activation of the human IgA receptor (FcalphaRI) by C-reactive protein." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, Issue 12, pp. 4974-9, (2011) (PubMed).

Duc, Johansen, Corthésy: "Antigen binding to secretory immunoglobulin A results in decreased sensitivity to intestinal proteases and increased binding to cellular Fc receptors." in: The Journal of biological chemistry, Vol. 285, Issue 2, pp. 953-60, (2010) (PubMed).

Yin, Peng, Xing, Zhang: "Intracellular pools of FcalphaR (CD89) in human neutrophils are localized in tertiary granules and secretory vesicles, and two FcalphaR isoforms are found in tertiary granules." in: Journal of leukocyte biology, Vol. 82, Issue 3, pp. 551-8, (2007) (PubMed).

Zhang, Bi, Oldroyd, Lachmann: "Neutrophil lactoferrin release induced by IgA immune complexes differed from that induced by cross-linking of fcalpha receptors (FcalphaR) with a monoclonal antibody, MIP8a." in: Clinical and experimental immunology, Vol. 121, Issue 1, pp. 106-11, (2000) (PubMed).

Synonyms and alternative names related to FCAR

Fc fragment of IgA receptor (FCAR), Fc fragment of IgA, receptor for (FCAR), CD89

Protein level used designations for FCAR

  • IgA Fc receptor
  • immunoglobulin A Fc receptor
  • immunoglobulin alpha Fc receptor
  • Fc fragment of IgA, receptor for, isoform 7
  • Fc alpha receptor
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