Protein tyrosine Phosphatase, Receptor Type, C (PTPRC) antibody

Details for Product No. ABIN120463
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Antigen
Synonyms PTPRC, si:dkeyp-47c5.1, B220, CD45, CD45R, GP180, L-CA, LCA, LY5, T200, Cd45, Ly-5, Lyt-4, loc, Lca, RT7, cd45
Reactivity
Rat (Rattus)
(653), (473), (135), (56), (40), (36), (31), (19), (19), (7), (5), (3), (3), (2), (2), (1), (1)
Host
Mouse
(679), (446), (143), (2), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(184), (121), (109), (60), (33), (19), (13), (12), (10), (9), (8), (8), (8), (8), (7), (6), (6), (6), (5), (5), (5), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS)
(1005), (213), (210), (201), (182), (148), (98), (94), (76), (40), (16), (8), (4), (2), (2), (2), (1), (1)
Pubmed 5 references available
Quantity 0.25 mg
Shipping to United States (Change)
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Catalog No. ABIN120463
308.00 $
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Immunogen Rat thymocyte membrane glycoproteins
Clone OX-1
Isotype IgG1
Specificity SM274P recognises CD45, also known as the leucocyte common antigen (LCA). The leucocyte common antigen consists of a family of heavily glycosylated membrane glycoproteins of molecular weight 180 - 240 kDa. Antibodies recognizing a common epitope on all of these isoforms are termed CD45, whilst those recognising only individual isoforms are termed CD45RA, CD45RO etc. OX-1 reacts with all forms of CD45 expressed by all haematopoietic cells, except erythrocytes. This product is routinely tested by flow cytometry on rat splenocytes.
Purification Protein G chromatography
Alternative Name CD45 / LCA
Background CD45 isoforms play complex roles in T-cell and B-cell antigen receptor signal transduction.
Alternate names: L-CA, Leukocyte common antigen, PTPRC, Receptor-type tyrosine-protein phosphatase C, T200
Gene ID 24699
NCBI Accession NP_001103357
UniProt P04157
Application Notes Flow cytometry: use 10 ul of 1/100 diluted antibody to label 10e6 cells. Immunohistochemistry on frozen sections (3). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer 0.09 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing. Dilute only prior to immediate use
Storage 4 °C/-20 °C
Storage Comment Store the antibody (undiluted) at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Supplier Images
anti-Protein tyrosine Phosphatase, Receptor Type, C (PTPRC) antibody Staining of rat peripheral blood lymphocytes with MOUSE ANTI RAT CD45 (ABIN120463).
General Standring, McMaster, Sunderland et al.: "The predominant heavily glycosylated glycoproteins at the surface of rat lymphoid cells are differentiation antigens." in: European journal of immunology, Vol. 8, Issue 12, pp. 832-9, 1979 (PubMed).

Sunderland, McMaster, Williams: "Purification with monoclonal antibody of a predominant leukocyte-common antigen and glycoprotein from rat thymocytes." in: European journal of immunology, Vol. 9, Issue 2, pp. 155-9, 1979 (PubMed).

Woollett, Barclay, Puklavec et al.: "Molecular and antigenic heterogeneity of the rat leukocyte-common antigen from thymocytes and T and B lymphocytes." in: European journal of immunology, Vol. 15, Issue 2, pp. 168-73, 1985 (PubMed).

Martín, Molina, Bricio et al.: "Passive dual immunization against tumour necrosis factor-alpha (TNF-alpha) and IL-1 beta maximally ameliorates acute aminonucleoside nephrosis." in: Clinical and experimental immunology, Vol. 99, Issue 2, pp. 283-8, 1995 (PubMed).

Sato, Balla, Otterbein et al.: "Carbon monoxide generated by heme oxygenase-1 suppresses the rejection of mouse-to-rat cardiac transplants." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 166, Issue 6, pp. 4185-94, 2001 (PubMed).

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